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Nanoparticles for Radiation Therapy Enhancement: the Key Parameters.

Retif P, Pinel S, Toussaint M, Frochot C, Chouikrat R, Bastogne T, Barberi-Heyob M - Theranostics (2015)

Bottom Line: It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy.Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist.We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy.

View Article: PubMed Central - PubMed

Affiliation: 1. CHR Metz-Thionville, Hôpital de Mercy, Service de radiothérapie, 1 allée du Château, Ars-Laquenexy, 57530, France; ; 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;

ABSTRACT
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.

No MeSH data available.


Luminescence of APF probe after X-rays excitation of nanoparticles composed of a Tb2O3 core, polysiloxane shell in which and porphyrins are covalently linked.
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Figure 7: Luminescence of APF probe after X-rays excitation of nanoparticles composed of a Tb2O3 core, polysiloxane shell in which and porphyrins are covalently linked.

Mentions: Our team published very recently a paper about X-ray-induced 1O2 activation with nanoscintillator-coupled porphyrins (Fig. 7) 73. Tb2O3 coated with a polysiloxane layer is a biocompatible nanoscintillator that exhibits an appropriate pattern of biodistribution in vivo after injection. The average size of the core-shell NPs grafted with porphyrin is 9.9 nm. Using time-resolved laser spectroscopy and 1O2 chemical probes, we demonstrated that after X-ray irradiation of the nano-objects, we could observe the formation of 1O2 as well as a decrease of the luminescence of the core and the increase of the fluorescence of the porphyrin, proving the energy transfer between the core and the photosensitizer. By elaborating new NPs, we hope to increase the efficiency and prove the concept in vitro and in vivo.


Nanoparticles for Radiation Therapy Enhancement: the Key Parameters.

Retif P, Pinel S, Toussaint M, Frochot C, Chouikrat R, Bastogne T, Barberi-Heyob M - Theranostics (2015)

Luminescence of APF probe after X-rays excitation of nanoparticles composed of a Tb2O3 core, polysiloxane shell in which and porphyrins are covalently linked.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4493540&req=5

Figure 7: Luminescence of APF probe after X-rays excitation of nanoparticles composed of a Tb2O3 core, polysiloxane shell in which and porphyrins are covalently linked.
Mentions: Our team published very recently a paper about X-ray-induced 1O2 activation with nanoscintillator-coupled porphyrins (Fig. 7) 73. Tb2O3 coated with a polysiloxane layer is a biocompatible nanoscintillator that exhibits an appropriate pattern of biodistribution in vivo after injection. The average size of the core-shell NPs grafted with porphyrin is 9.9 nm. Using time-resolved laser spectroscopy and 1O2 chemical probes, we demonstrated that after X-ray irradiation of the nano-objects, we could observe the formation of 1O2 as well as a decrease of the luminescence of the core and the increase of the fluorescence of the porphyrin, proving the energy transfer between the core and the photosensitizer. By elaborating new NPs, we hope to increase the efficiency and prove the concept in vitro and in vivo.

Bottom Line: It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy.Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist.We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy.

View Article: PubMed Central - PubMed

Affiliation: 1. CHR Metz-Thionville, Hôpital de Mercy, Service de radiothérapie, 1 allée du Château, Ars-Laquenexy, 57530, France; ; 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;

ABSTRACT
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.

No MeSH data available.