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Nanoparticles for Radiation Therapy Enhancement: the Key Parameters.

Retif P, Pinel S, Toussaint M, Frochot C, Chouikrat R, Bastogne T, Barberi-Heyob M - Theranostics (2015)

Bottom Line: It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy.Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist.We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy.

View Article: PubMed Central - PubMed

Affiliation: 1. CHR Metz-Thionville, Hôpital de Mercy, Service de radiothérapie, 1 allée du Château, Ars-Laquenexy, 57530, France; ; 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;

ABSTRACT
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.

No MeSH data available.


Example of a standard irradiation setup for a 6 MV irradiation of a cell-well plate placed at the linear accelerator's isocenter under 5 cm of water-equivalent slabs.
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Figure 4: Example of a standard irradiation setup for a 6 MV irradiation of a cell-well plate placed at the linear accelerator's isocenter under 5 cm of water-equivalent slabs.

Mentions: The energy held by the scattered photon is related to the energy of the incident photon 53. Therefore backscattered photons, which carry less energy, are interesting for X-rays-NPs interactions purposes. Then the cells/tissues/tumor should be located in a low dose gradient: after the depth of the maximum dose and inside the beam, off the penumbra region. Sufficient medium should be placed after the cells/tissues/tumor in order to generate enough scattered photons (Compton effect). Finally, cells/tissue/tumor should be at a clinical distance from the source (e.g. 100 cm for a high-energy medical accelerator). Advices from a medical physicist could be of great use. The figure 4 illustrates an example of an irradiation scheme for a 6 MV accelerator treating a cell well plate.


Nanoparticles for Radiation Therapy Enhancement: the Key Parameters.

Retif P, Pinel S, Toussaint M, Frochot C, Chouikrat R, Bastogne T, Barberi-Heyob M - Theranostics (2015)

Example of a standard irradiation setup for a 6 MV irradiation of a cell-well plate placed at the linear accelerator's isocenter under 5 cm of water-equivalent slabs.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4493540&req=5

Figure 4: Example of a standard irradiation setup for a 6 MV irradiation of a cell-well plate placed at the linear accelerator's isocenter under 5 cm of water-equivalent slabs.
Mentions: The energy held by the scattered photon is related to the energy of the incident photon 53. Therefore backscattered photons, which carry less energy, are interesting for X-rays-NPs interactions purposes. Then the cells/tissues/tumor should be located in a low dose gradient: after the depth of the maximum dose and inside the beam, off the penumbra region. Sufficient medium should be placed after the cells/tissues/tumor in order to generate enough scattered photons (Compton effect). Finally, cells/tissue/tumor should be at a clinical distance from the source (e.g. 100 cm for a high-energy medical accelerator). Advices from a medical physicist could be of great use. The figure 4 illustrates an example of an irradiation scheme for a 6 MV accelerator treating a cell well plate.

Bottom Line: It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy.Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist.We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy.

View Article: PubMed Central - PubMed

Affiliation: 1. CHR Metz-Thionville, Hôpital de Mercy, Service de radiothérapie, 1 allée du Château, Ars-Laquenexy, 57530, France; ; 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;

ABSTRACT
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.

No MeSH data available.