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Nanoparticles for Radiation Therapy Enhancement: the Key Parameters.

Retif P, Pinel S, Toussaint M, Frochot C, Chouikrat R, Bastogne T, Barberi-Heyob M - Theranostics (2015)

Bottom Line: It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy.Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist.We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy.

View Article: PubMed Central - PubMed

Affiliation: 1. CHR Metz-Thionville, Hôpital de Mercy, Service de radiothérapie, 1 allée du Château, Ars-Laquenexy, 57530, France; ; 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;

ABSTRACT
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.

No MeSH data available.


Survival curve example. Illustration of our DMF assessment strategy.
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Figure 2: Survival curve example. Illustration of our DMF assessment strategy.

Mentions: We divided the performed studies using medical X-rays into two categories: the first one corresponds to low and medium energies, i.e. comprised between 1 kV and 1 MV and the other one corresponds to high energies (i.e. 1 to 25 MV). When achievable, we measured the DMF in papers that contain survival curves to quantify the radiosensitizing effect of NPs. The "biological effect" was defined as the SF2 without NPs (Fig. 2).


Nanoparticles for Radiation Therapy Enhancement: the Key Parameters.

Retif P, Pinel S, Toussaint M, Frochot C, Chouikrat R, Bastogne T, Barberi-Heyob M - Theranostics (2015)

Survival curve example. Illustration of our DMF assessment strategy.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4493540&req=5

Figure 2: Survival curve example. Illustration of our DMF assessment strategy.
Mentions: We divided the performed studies using medical X-rays into two categories: the first one corresponds to low and medium energies, i.e. comprised between 1 kV and 1 MV and the other one corresponds to high energies (i.e. 1 to 25 MV). When achievable, we measured the DMF in papers that contain survival curves to quantify the radiosensitizing effect of NPs. The "biological effect" was defined as the SF2 without NPs (Fig. 2).

Bottom Line: It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy.Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist.We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy.

View Article: PubMed Central - PubMed

Affiliation: 1. CHR Metz-Thionville, Hôpital de Mercy, Service de radiothérapie, 1 allée du Château, Ars-Laquenexy, 57530, France; ; 2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France; ; 3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;

ABSTRACT
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.

No MeSH data available.