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Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.

Yu J, Yin W, Zheng X, Tian G, Zhang X, Bao T, Dong X, Wang Z, Gu Z, Ma X, Zhao Y - Theranostics (2015)

Bottom Line: The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method.And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo.Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption.

View Article: PubMed Central - PubMed

Affiliation: 1. Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China ; 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China.

ABSTRACT
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.

No MeSH data available.


Related in: MedlinePlus

(a) Stability tests of MSIOs in DMEM, FBS, PBS, and water dispersions. (b) Magnetization loops of MSIOs. Inset is a photo of MSIOs solution placed nearby magnets. (c) Temperature changes based on the MoS2 concentration in the MSIOs dispersion under 808-nm NIR laser irradiation (the stoichiometric composition of the MoS2 was quantified by the ICP-MS based on Mo element). (d) Temperature change plot over the time of 10 min versus different MoS2 concentration in the MSIOs dispersion in (c).
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Figure 3: (a) Stability tests of MSIOs in DMEM, FBS, PBS, and water dispersions. (b) Magnetization loops of MSIOs. Inset is a photo of MSIOs solution placed nearby magnets. (c) Temperature changes based on the MoS2 concentration in the MSIOs dispersion under 808-nm NIR laser irradiation (the stoichiometric composition of the MoS2 was quantified by the ICP-MS based on Mo element). (d) Temperature change plot over the time of 10 min versus different MoS2 concentration in the MSIOs dispersion in (c).

Mentions: In Figure 3a, it can be clearly seen that the PEG modified MSIOs have a good stability in biological media including DMEM, FBS, PBS, as well as water for at least 2 days, allowing the MSIOs to be further used in biological or physiological environments. Magnetization measurements showed that MSIOs possess a saturation magnetization of 33.4 emu/g, indicating a super-paramagnetic nature of the MSIOs at room temperature (Figure 3b). The UV-Vis-NIR absorbance spectrum of MSIOs exhibits a strong absorption band from UV to NIR region (Supplementary Figure S7), which has a negligible decrease for the absorption at the 808 nm compared with the pure MoS2 with the same content as the MSIOs. To verify the potential use of MSIOs as a PTT agent, the MSIOs aqueous solutions with different MoS2 concentrations were irradiated with 808-nm NIR laser at a power density of 1 W cm-2 for 10 min. In marked contrast to the water sample, the MSIOs solution shows a concentration-dependent temperature increase (Figure 3c,d). The NIR photothermal transduction ability of MSIOs was also investigated when the temperature change of the MoS2 nanoflakes with concentration of 170 ppm as a function of time were measured under the 808 nm laser (1.0 W/cm2, 10 min) (Supplementary Figure S8). According to the obtained data, the photothermal conversion efficiency of MSIOs can reach ∼43.93% (Supplementary Material).


Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.

Yu J, Yin W, Zheng X, Tian G, Zhang X, Bao T, Dong X, Wang Z, Gu Z, Ma X, Zhao Y - Theranostics (2015)

(a) Stability tests of MSIOs in DMEM, FBS, PBS, and water dispersions. (b) Magnetization loops of MSIOs. Inset is a photo of MSIOs solution placed nearby magnets. (c) Temperature changes based on the MoS2 concentration in the MSIOs dispersion under 808-nm NIR laser irradiation (the stoichiometric composition of the MoS2 was quantified by the ICP-MS based on Mo element). (d) Temperature change plot over the time of 10 min versus different MoS2 concentration in the MSIOs dispersion in (c).
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4493532&req=5

Figure 3: (a) Stability tests of MSIOs in DMEM, FBS, PBS, and water dispersions. (b) Magnetization loops of MSIOs. Inset is a photo of MSIOs solution placed nearby magnets. (c) Temperature changes based on the MoS2 concentration in the MSIOs dispersion under 808-nm NIR laser irradiation (the stoichiometric composition of the MoS2 was quantified by the ICP-MS based on Mo element). (d) Temperature change plot over the time of 10 min versus different MoS2 concentration in the MSIOs dispersion in (c).
Mentions: In Figure 3a, it can be clearly seen that the PEG modified MSIOs have a good stability in biological media including DMEM, FBS, PBS, as well as water for at least 2 days, allowing the MSIOs to be further used in biological or physiological environments. Magnetization measurements showed that MSIOs possess a saturation magnetization of 33.4 emu/g, indicating a super-paramagnetic nature of the MSIOs at room temperature (Figure 3b). The UV-Vis-NIR absorbance spectrum of MSIOs exhibits a strong absorption band from UV to NIR region (Supplementary Figure S7), which has a negligible decrease for the absorption at the 808 nm compared with the pure MoS2 with the same content as the MSIOs. To verify the potential use of MSIOs as a PTT agent, the MSIOs aqueous solutions with different MoS2 concentrations were irradiated with 808-nm NIR laser at a power density of 1 W cm-2 for 10 min. In marked contrast to the water sample, the MSIOs solution shows a concentration-dependent temperature increase (Figure 3c,d). The NIR photothermal transduction ability of MSIOs was also investigated when the temperature change of the MoS2 nanoflakes with concentration of 170 ppm as a function of time were measured under the 808 nm laser (1.0 W/cm2, 10 min) (Supplementary Figure S8). According to the obtained data, the photothermal conversion efficiency of MSIOs can reach ∼43.93% (Supplementary Material).

Bottom Line: The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method.And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo.Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption.

View Article: PubMed Central - PubMed

Affiliation: 1. Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China ; 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China.

ABSTRACT
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.

No MeSH data available.


Related in: MedlinePlus