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Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.

Yu J, Yin W, Zheng X, Tian G, Zhang X, Bao T, Dong X, Wang Z, Gu Z, Ma X, Zhao Y - Theranostics (2015)

Bottom Line: The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method.And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo.Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption.

View Article: PubMed Central - PubMed

Affiliation: 1. Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China ; 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China.

ABSTRACT
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.

No MeSH data available.


Related in: MedlinePlus

(a) TEM and (b) corresponding EDX element mapping images of MSIOs, revealing the distribution of Mo(Green), S(sienna), Fe(yellow) and O(red) elements. (c) XPS survey spectrum of MSIOs and (d) Mo, (e) S, (f) Fe, and (g) O elements XPS spectra, together with their corresponding fitting curves (the fitting curves were marked with the dotted lines). (h) FT-IR spectra of MSIOs (Red line: MoS2 nanoflakes, black line: MSIOs). Inset in (a): STEM image of the MSIOs.
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Figure 2: (a) TEM and (b) corresponding EDX element mapping images of MSIOs, revealing the distribution of Mo(Green), S(sienna), Fe(yellow) and O(red) elements. (c) XPS survey spectrum of MSIOs and (d) Mo, (e) S, (f) Fe, and (g) O elements XPS spectra, together with their corresponding fitting curves (the fitting curves were marked with the dotted lines). (h) FT-IR spectra of MSIOs (Red line: MoS2 nanoflakes, black line: MSIOs). Inset in (a): STEM image of the MSIOs.

Mentions: The MSIOs composite was confirmed by the EDX spectra (Supplementary Figure S4) and element mapping. As shown in Figure 2a-b, the element mapping indicates the presence of Fe and O elements signals around the Mo and S signals, further indicating that the Fe3O4 NPs are located on the surface of MoS2 nanoflakes. XPS analysis gives more detailed chemical state of the MoS2 (Supplementary Figure S5) and MSIOs (Figure 2c-g). Figure 2c shows a survey XPS plot of the MSIOs with peaks of Mo, S, Fe, and O elements. In Figure 2d, three XPS peaks at 228, 232 and 235 eV correspond to the Mo3d5/2 (Mo4+), Mo3d3/2 (Mo4+), and Mo3d5/2 (Mo6+), respectively, and the lower-energy peak at ~225 eV represents the S2s orbital signal. The XPS curve of S2p elements are shown in Figure 2e, two peaks at 161 and 162 eV, correspond to the 2p3/2 and 2p1/2 of divalent sulfide ions (S2-), and a peak at 168 eV correspond to the 2p3/2 of hexavalent sulfide atom in sulfate (SO42-), respectively. The slight change of the oxidation state of Mo and S elements could be attributed to the negligible surface oxidation of MoS2 nanoflakes during second hydrothermal step and the relative elements atom content analysis implied the absorption of Fe containing compound on the MoS2 nanoflakes surface (Supplementary Table S1). All these results further prove that the as-prepared MSIOs sample consist of MoS2, which is in good agreement with those reported values of MoS2 crystal although a negligible oxidation of Mo4+ to Mo6+ was found due to the hydrothermal process 39. The XPS curve of Fe2p with a peak at 710 eV can be observed in Figure 2f. The two fitted curves with the peaks at 708.8 and 709.7 eV reveal that a new compound composed of Fe and S elements are formed on the surface of MSIOs, which is composed of ferric and ferrous iron and divalent sulfur in MSIOs, respectively 40, suggesting the existence of Fe-S bond. The XPS curve of Fe2p with peaks at 711.3, 712.4, and 713.6 eV can be assigned to the Fe3+ and peaks at 709.3 and 710.4 eV can be assigned to the Fe2+ in Figure 2f, which are the characteristic peaks of Fe2p3/2 in Fe3O4, suggesting the coexistence of Fe2+ and Fe3+41. Figure 2g shows O1s curve with peaks at 529 and 531 eV, respectively. The peaks at 529 eV can be attributed to the lattice oxygen of Fe3O4 and the 531 eV can be assigned to the hydroxyl group originating from the surface modification 42.


Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.

Yu J, Yin W, Zheng X, Tian G, Zhang X, Bao T, Dong X, Wang Z, Gu Z, Ma X, Zhao Y - Theranostics (2015)

(a) TEM and (b) corresponding EDX element mapping images of MSIOs, revealing the distribution of Mo(Green), S(sienna), Fe(yellow) and O(red) elements. (c) XPS survey spectrum of MSIOs and (d) Mo, (e) S, (f) Fe, and (g) O elements XPS spectra, together with their corresponding fitting curves (the fitting curves were marked with the dotted lines). (h) FT-IR spectra of MSIOs (Red line: MoS2 nanoflakes, black line: MSIOs). Inset in (a): STEM image of the MSIOs.
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Related In: Results  -  Collection

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Figure 2: (a) TEM and (b) corresponding EDX element mapping images of MSIOs, revealing the distribution of Mo(Green), S(sienna), Fe(yellow) and O(red) elements. (c) XPS survey spectrum of MSIOs and (d) Mo, (e) S, (f) Fe, and (g) O elements XPS spectra, together with their corresponding fitting curves (the fitting curves were marked with the dotted lines). (h) FT-IR spectra of MSIOs (Red line: MoS2 nanoflakes, black line: MSIOs). Inset in (a): STEM image of the MSIOs.
Mentions: The MSIOs composite was confirmed by the EDX spectra (Supplementary Figure S4) and element mapping. As shown in Figure 2a-b, the element mapping indicates the presence of Fe and O elements signals around the Mo and S signals, further indicating that the Fe3O4 NPs are located on the surface of MoS2 nanoflakes. XPS analysis gives more detailed chemical state of the MoS2 (Supplementary Figure S5) and MSIOs (Figure 2c-g). Figure 2c shows a survey XPS plot of the MSIOs with peaks of Mo, S, Fe, and O elements. In Figure 2d, three XPS peaks at 228, 232 and 235 eV correspond to the Mo3d5/2 (Mo4+), Mo3d3/2 (Mo4+), and Mo3d5/2 (Mo6+), respectively, and the lower-energy peak at ~225 eV represents the S2s orbital signal. The XPS curve of S2p elements are shown in Figure 2e, two peaks at 161 and 162 eV, correspond to the 2p3/2 and 2p1/2 of divalent sulfide ions (S2-), and a peak at 168 eV correspond to the 2p3/2 of hexavalent sulfide atom in sulfate (SO42-), respectively. The slight change of the oxidation state of Mo and S elements could be attributed to the negligible surface oxidation of MoS2 nanoflakes during second hydrothermal step and the relative elements atom content analysis implied the absorption of Fe containing compound on the MoS2 nanoflakes surface (Supplementary Table S1). All these results further prove that the as-prepared MSIOs sample consist of MoS2, which is in good agreement with those reported values of MoS2 crystal although a negligible oxidation of Mo4+ to Mo6+ was found due to the hydrothermal process 39. The XPS curve of Fe2p with a peak at 710 eV can be observed in Figure 2f. The two fitted curves with the peaks at 708.8 and 709.7 eV reveal that a new compound composed of Fe and S elements are formed on the surface of MSIOs, which is composed of ferric and ferrous iron and divalent sulfur in MSIOs, respectively 40, suggesting the existence of Fe-S bond. The XPS curve of Fe2p with peaks at 711.3, 712.4, and 713.6 eV can be assigned to the Fe3+ and peaks at 709.3 and 710.4 eV can be assigned to the Fe2+ in Figure 2f, which are the characteristic peaks of Fe2p3/2 in Fe3O4, suggesting the coexistence of Fe2+ and Fe3+41. Figure 2g shows O1s curve with peaks at 529 and 531 eV, respectively. The peaks at 529 eV can be attributed to the lattice oxygen of Fe3O4 and the 531 eV can be assigned to the hydroxyl group originating from the surface modification 42.

Bottom Line: The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method.And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo.Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption.

View Article: PubMed Central - PubMed

Affiliation: 1. Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China ; 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China.

ABSTRACT
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.

No MeSH data available.


Related in: MedlinePlus