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Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.

Yu J, Yin W, Zheng X, Tian G, Zhang X, Bao T, Dong X, Wang Z, Gu Z, Ma X, Zhao Y - Theranostics (2015)

Bottom Line: The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method.And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo.Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption.

View Article: PubMed Central - PubMed

Affiliation: 1. Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China ; 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China.

ABSTRACT
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.

No MeSH data available.


Related in: MedlinePlus

Schematic illustration of the synthesis route and theranostic procedure of MSIOs for dual-modal MR and PAT imaging-guided magnetic targeting photothermal ablation of cancer.
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Related In: Results  -  Collection


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SC1: Schematic illustration of the synthesis route and theranostic procedure of MSIOs for dual-modal MR and PAT imaging-guided magnetic targeting photothermal ablation of cancer.

Mentions: Herein, a versatile theranostic nanoagent were successfully designed by a simple two-step hydrothermal method, in which ultra-small Fe3O4 NPs were attached on the surface of the multilayer MoS2 nanoflakes to form MSIOs composite (Scheme 1a-b). Subsequently, the MSIOs modified by poly-(ethylene glycol) (PEG) to impart good biocompatibility were further demonstrated for magnetic targeted dual-modal MR/PAT imaging in vitro and in vivo. Moreover, the photothermal efficiency contributed by the MoS2 nanoflakes under 808-nm NIR laser irradiation and magnetic target induced by the Fe3O4 in the MSIOs were utilized for realizing effective magnetic targeted photothermal ablation of cancer. Thus, the MSIOs not only have effective magnetic targeted PTT to cancer but also afford MR and PAT imaging properties (Scheme 1c). Therefore, under the external magnetic field, the MSIOs as an effective theranostic nanoagent show great potential for simultaneous multimodal MR/PAT imaging-guided diagnosis and magnetic targeting PTT to cancer.


Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.

Yu J, Yin W, Zheng X, Tian G, Zhang X, Bao T, Dong X, Wang Z, Gu Z, Ma X, Zhao Y - Theranostics (2015)

Schematic illustration of the synthesis route and theranostic procedure of MSIOs for dual-modal MR and PAT imaging-guided magnetic targeting photothermal ablation of cancer.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4493532&req=5

SC1: Schematic illustration of the synthesis route and theranostic procedure of MSIOs for dual-modal MR and PAT imaging-guided magnetic targeting photothermal ablation of cancer.
Mentions: Herein, a versatile theranostic nanoagent were successfully designed by a simple two-step hydrothermal method, in which ultra-small Fe3O4 NPs were attached on the surface of the multilayer MoS2 nanoflakes to form MSIOs composite (Scheme 1a-b). Subsequently, the MSIOs modified by poly-(ethylene glycol) (PEG) to impart good biocompatibility were further demonstrated for magnetic targeted dual-modal MR/PAT imaging in vitro and in vivo. Moreover, the photothermal efficiency contributed by the MoS2 nanoflakes under 808-nm NIR laser irradiation and magnetic target induced by the Fe3O4 in the MSIOs were utilized for realizing effective magnetic targeted photothermal ablation of cancer. Thus, the MSIOs not only have effective magnetic targeted PTT to cancer but also afford MR and PAT imaging properties (Scheme 1c). Therefore, under the external magnetic field, the MSIOs as an effective theranostic nanoagent show great potential for simultaneous multimodal MR/PAT imaging-guided diagnosis and magnetic targeting PTT to cancer.

Bottom Line: The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method.And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo.Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption.

View Article: PubMed Central - PubMed

Affiliation: 1. Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China ; 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China.

ABSTRACT
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.

No MeSH data available.


Related in: MedlinePlus