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Nanomedicine approaches for corneal diseases.

Chaurasia SS, Lim RR, Lakshminarayanan R, Mohan RR - J Funct Biomater (2015)

Bottom Line: This often results in poor efficacy and several side-effects.The promise of nanomedicine approaches for treating corneal defects and restoring vision without side effects in preclinical animal studies has been demonstrated.Numerous polymeric, metallic and hybrid nanoparticles capable of transporting genes into desired corneal cells to intercept pathologic pathways and processes leading to blindness have been identified.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology Veterinary Medicine & Surgery, Columbia, MO 65211, USA. chaurasias@missouri.edu.

ABSTRACT
Corneal diseases are the third leading cause of blindness globally. Topical nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used to treat corneal pathological conditions. However, barrier properties of the ocular surface necessitate high concentration of the drugs applied in the eye repeatedly. This often results in poor efficacy and several side-effects. Nanoparticle-based molecular medicine seeks to overcome these limitations by enhancing the permeability and pharmacological properties of the drugs. The promise of nanomedicine approaches for treating corneal defects and restoring vision without side effects in preclinical animal studies has been demonstrated. Numerous polymeric, metallic and hybrid nanoparticles capable of transporting genes into desired corneal cells to intercept pathologic pathways and processes leading to blindness have been identified. This review provides an overview of corneal diseases, nanovector properties and their applications in drug-delivery and corneal disease management.

No MeSH data available.


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Schematic diagram depicting nanomedicine techniques available for corneal diseases.
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jfb-06-00277-f004: Schematic diagram depicting nanomedicine techniques available for corneal diseases.

Mentions: Nanomedicine is an emerging field of medical science which utilizes nanotechnology to study the functioning of the living cells at the molecular level and nanomaterials to develop newer drug delivery modalities for the treatment of human diseases. Nanotechnology has been used in almost every field of medical science including imaging, diagnosis, biosensors and drug delivery. In the following section, current nanomedicine tools that have been tested for the treatment of corneal diseases are described (Figure 4).


Nanomedicine approaches for corneal diseases.

Chaurasia SS, Lim RR, Lakshminarayanan R, Mohan RR - J Funct Biomater (2015)

Schematic diagram depicting nanomedicine techniques available for corneal diseases.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493512&req=5

jfb-06-00277-f004: Schematic diagram depicting nanomedicine techniques available for corneal diseases.
Mentions: Nanomedicine is an emerging field of medical science which utilizes nanotechnology to study the functioning of the living cells at the molecular level and nanomaterials to develop newer drug delivery modalities for the treatment of human diseases. Nanotechnology has been used in almost every field of medical science including imaging, diagnosis, biosensors and drug delivery. In the following section, current nanomedicine tools that have been tested for the treatment of corneal diseases are described (Figure 4).

Bottom Line: This often results in poor efficacy and several side-effects.The promise of nanomedicine approaches for treating corneal defects and restoring vision without side effects in preclinical animal studies has been demonstrated.Numerous polymeric, metallic and hybrid nanoparticles capable of transporting genes into desired corneal cells to intercept pathologic pathways and processes leading to blindness have been identified.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology Veterinary Medicine & Surgery, Columbia, MO 65211, USA. chaurasias@missouri.edu.

ABSTRACT
Corneal diseases are the third leading cause of blindness globally. Topical nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used to treat corneal pathological conditions. However, barrier properties of the ocular surface necessitate high concentration of the drugs applied in the eye repeatedly. This often results in poor efficacy and several side-effects. Nanoparticle-based molecular medicine seeks to overcome these limitations by enhancing the permeability and pharmacological properties of the drugs. The promise of nanomedicine approaches for treating corneal defects and restoring vision without side effects in preclinical animal studies has been demonstrated. Numerous polymeric, metallic and hybrid nanoparticles capable of transporting genes into desired corneal cells to intercept pathologic pathways and processes leading to blindness have been identified. This review provides an overview of corneal diseases, nanovector properties and their applications in drug-delivery and corneal disease management.

No MeSH data available.


Related in: MedlinePlus