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Aichi virus 1: environmental occurrence and behavior.

Kitajima M, Gerba CP - Pathogens (2015)

Bottom Line: Aichi virus 1 (AiV-1), belonging to the genus Kobuvirus in the family Picornaviridae, has been proposed as a causative agent of human gastroenteritis potentially transmitted by fecal-oral routes through contaminated food or water.AiV-1 is globally distributed and has been detected in various types of environmental samples, such as sewage, river water, groundwater, and shellfish.Further studies on the occurrence and fate of AiV-1 in environments, even in combination with clinical studies of many regions, are needed for a better understanding of their epidemiology, temporal and geographical distribution, environmental stability, and potential health risks to humans.

View Article: PubMed Central - PubMed

Affiliation: Department of Soil, Water and Environmental Science, The University of Arizona, 1117 E. Lowell St., Tucson, AZ 85721, USA. kitajima@smart.mit.edu.

ABSTRACT
Aichi virus 1 (AiV-1), belonging to the genus Kobuvirus in the family Picornaviridae, has been proposed as a causative agent of human gastroenteritis potentially transmitted by fecal-oral routes through contaminated food or water. AiV-1 is globally distributed and has been detected in various types of environmental samples, such as sewage, river water, groundwater, and shellfish. Recent environmental studies revealed that this virus could be detected in higher frequency and greater abundance than other human enteric viruses. These findings suggest that AiV-1 could potentially be an appropriate indicator of viral contamination in the environment because of its high prevalence in water environments as well as structural and genetic similarity with some of the other important enteric viruses. Further studies on the occurrence and fate of AiV-1 in environments, even in combination with clinical studies of many regions, are needed for a better understanding of their epidemiology, temporal and geographical distribution, environmental stability, and potential health risks to humans.

No MeSH data available.


Related in: MedlinePlus

Genome organization of Aichi virus 1 and target locations of diagnostic PCR assays.
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pathogens-04-00256-f002: Genome organization of Aichi virus 1 and target locations of diagnostic PCR assays.

Mentions: AiV-1 possesses a single-stranded, positive-sense RNA genome approximately 8.3 kb in length, which is comprised of a 5' untranslated region (UTR) with an internal ribosomal entry site (IRES), a large open reading frame (ORF) of approximately 7.3 kb encoding a single polyprotein (putative protein precursor), and a 3' UTR region [2,7,8,9]. As shown in Figure 2, a non-structural leader (L) protein is encoded at the N-terminus of the polyprotein, followed by viral structural proteins P1 (VP0, VP3, and VP1) and non-structural proteins P2 (2A, 2B, and 2C) and P3 (3A, 3B, 3C, and 3D) [2,7,8,9].


Aichi virus 1: environmental occurrence and behavior.

Kitajima M, Gerba CP - Pathogens (2015)

Genome organization of Aichi virus 1 and target locations of diagnostic PCR assays.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493473&req=5

pathogens-04-00256-f002: Genome organization of Aichi virus 1 and target locations of diagnostic PCR assays.
Mentions: AiV-1 possesses a single-stranded, positive-sense RNA genome approximately 8.3 kb in length, which is comprised of a 5' untranslated region (UTR) with an internal ribosomal entry site (IRES), a large open reading frame (ORF) of approximately 7.3 kb encoding a single polyprotein (putative protein precursor), and a 3' UTR region [2,7,8,9]. As shown in Figure 2, a non-structural leader (L) protein is encoded at the N-terminus of the polyprotein, followed by viral structural proteins P1 (VP0, VP3, and VP1) and non-structural proteins P2 (2A, 2B, and 2C) and P3 (3A, 3B, 3C, and 3D) [2,7,8,9].

Bottom Line: Aichi virus 1 (AiV-1), belonging to the genus Kobuvirus in the family Picornaviridae, has been proposed as a causative agent of human gastroenteritis potentially transmitted by fecal-oral routes through contaminated food or water.AiV-1 is globally distributed and has been detected in various types of environmental samples, such as sewage, river water, groundwater, and shellfish.Further studies on the occurrence and fate of AiV-1 in environments, even in combination with clinical studies of many regions, are needed for a better understanding of their epidemiology, temporal and geographical distribution, environmental stability, and potential health risks to humans.

View Article: PubMed Central - PubMed

Affiliation: Department of Soil, Water and Environmental Science, The University of Arizona, 1117 E. Lowell St., Tucson, AZ 85721, USA. kitajima@smart.mit.edu.

ABSTRACT
Aichi virus 1 (AiV-1), belonging to the genus Kobuvirus in the family Picornaviridae, has been proposed as a causative agent of human gastroenteritis potentially transmitted by fecal-oral routes through contaminated food or water. AiV-1 is globally distributed and has been detected in various types of environmental samples, such as sewage, river water, groundwater, and shellfish. Recent environmental studies revealed that this virus could be detected in higher frequency and greater abundance than other human enteric viruses. These findings suggest that AiV-1 could potentially be an appropriate indicator of viral contamination in the environment because of its high prevalence in water environments as well as structural and genetic similarity with some of the other important enteric viruses. Further studies on the occurrence and fate of AiV-1 in environments, even in combination with clinical studies of many regions, are needed for a better understanding of their epidemiology, temporal and geographical distribution, environmental stability, and potential health risks to humans.

No MeSH data available.


Related in: MedlinePlus