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Functional neuroimaging correlates of autobiographical memory deficits in subjects at risk for depression.

Young KD, Bellgowan PS, Bodurka J, Drevets WC - Brain Sci (2015)

Bottom Line: During specific AM recall, HRs had increased activity relative to rMDDs and HCs in left ventrolateral prefrontal cortex (VLPFC) and lateral orbitofrontal cortex.During positive specific AM recall, HRs and HCs had increased activity relative to rMDDs in bilateral dorsomedial prefrontal cortex (DMPFC) and left precuneus.During negative specific AM recall HRs and HCs had increased activity in left VLPFC and right DMPFC, while rMDDs had increased activity relative to HRs and HCs in right DLPFC and precuneus.

View Article: PubMed Central - PubMed

Affiliation: Laureate Institute for Brain Research, 6655 South Yale Avenue, Tulsa, OK 74136, USA. kyoung@laureateinstitute.org.

ABSTRACT
Overgeneral autobiographical memory (AM) manifests in individuals with major depressive disorder (MDD) tested during depressed (dMDD) or remitted phases (rMDD), and healthy individuals at high-risk (HR) for developing MDD. The current study aimed to elucidate differences in hemodynamic correlates of AM recall between rMDDs, HRs, and controls (HCs) to identify neural changes following previous depressive episodes without the confound of current depressed mood. HCs, HRs, and unmedicated rMDDs (n = 20/group) underwent fMRI while recalling AMs in response to emotionally valenced cue words. HRs and rMDDs recalled fewer specific and more categorical AMs relative to HCs. During specific AM recall, HRs had increased activity relative to rMDDs and HCs in left ventrolateral prefrontal cortex (VLPFC) and lateral orbitofrontal cortex. During positive specific AM recall, HRs and HCs had increased activity relative to rMDDs in bilateral dorsomedial prefrontal cortex (DMPFC) and left precuneus. During negative specific AM recall HRs and HCs had increased activity in left VLPFC and right DMPFC, while rMDDs had increased activity relative to HRs and HCs in right DLPFC and precuneus. Differential recruitment of medial prefrontal regions implicated in emotional control suggests experiencing a depressive episode may consequently reduce one's ability to regulate emotional responses during AM recall.

No MeSH data available.


Related in: MedlinePlus

Differences in BOLD activity between HC, HR, and rMDD groups during negative specific AM recall. Regions (A) left ventrolateral PFC; (B) right dorsomedial PFC; (C) right precuneus; and (D) right dorsolateral PFC are shown where groups had differential BOLD activity during Negative Specific AM recall versus Negative Example Generation (pcorrected < 0.05). Using the significant clusters in Table 3 as ROIs, beta weights were extracted for the Negative Specific AMs versus Riser Baseline conditions, and for the Negative Example Generation versus Riser Baseline conditions. Error bars indicate +/− one standard error of the mean. Abbreviations defined in the legend for Figure 1.
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brainsci-05-00144-f003: Differences in BOLD activity between HC, HR, and rMDD groups during negative specific AM recall. Regions (A) left ventrolateral PFC; (B) right dorsomedial PFC; (C) right precuneus; and (D) right dorsolateral PFC are shown where groups had differential BOLD activity during Negative Specific AM recall versus Negative Example Generation (pcorrected < 0.05). Using the significant clusters in Table 3 as ROIs, beta weights were extracted for the Negative Specific AMs versus Riser Baseline conditions, and for the Negative Example Generation versus Riser Baseline conditions. Error bars indicate +/− one standard error of the mean. Abbreviations defined in the legend for Figure 1.

Mentions: Group differences in BOLD activity were also evident in the additional contrasts comparing Positive Specific Recall versus Positive Example Generation and Negative Specific Recall versus Negative Example Generation. During positive AM recall versus positive example generation both HC and HR participants showed increased BOLD activity relative to rMDD participants in bilateral DMPFC/BA9 and left precuneus (Figure 2). During negative AM recall versus negative example generation (Figure 3) HC and HR participants had increased BOLD activity relative to rMDD participants in right DMPFC/BA9 and left VLPFC, while the rMDD participants had increased BOLD activity relative to HC and HR participants in right DLPFC and precuneus for this contrast.


Functional neuroimaging correlates of autobiographical memory deficits in subjects at risk for depression.

Young KD, Bellgowan PS, Bodurka J, Drevets WC - Brain Sci (2015)

Differences in BOLD activity between HC, HR, and rMDD groups during negative specific AM recall. Regions (A) left ventrolateral PFC; (B) right dorsomedial PFC; (C) right precuneus; and (D) right dorsolateral PFC are shown where groups had differential BOLD activity during Negative Specific AM recall versus Negative Example Generation (pcorrected < 0.05). Using the significant clusters in Table 3 as ROIs, beta weights were extracted for the Negative Specific AMs versus Riser Baseline conditions, and for the Negative Example Generation versus Riser Baseline conditions. Error bars indicate +/− one standard error of the mean. Abbreviations defined in the legend for Figure 1.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493461&req=5

brainsci-05-00144-f003: Differences in BOLD activity between HC, HR, and rMDD groups during negative specific AM recall. Regions (A) left ventrolateral PFC; (B) right dorsomedial PFC; (C) right precuneus; and (D) right dorsolateral PFC are shown where groups had differential BOLD activity during Negative Specific AM recall versus Negative Example Generation (pcorrected < 0.05). Using the significant clusters in Table 3 as ROIs, beta weights were extracted for the Negative Specific AMs versus Riser Baseline conditions, and for the Negative Example Generation versus Riser Baseline conditions. Error bars indicate +/− one standard error of the mean. Abbreviations defined in the legend for Figure 1.
Mentions: Group differences in BOLD activity were also evident in the additional contrasts comparing Positive Specific Recall versus Positive Example Generation and Negative Specific Recall versus Negative Example Generation. During positive AM recall versus positive example generation both HC and HR participants showed increased BOLD activity relative to rMDD participants in bilateral DMPFC/BA9 and left precuneus (Figure 2). During negative AM recall versus negative example generation (Figure 3) HC and HR participants had increased BOLD activity relative to rMDD participants in right DMPFC/BA9 and left VLPFC, while the rMDD participants had increased BOLD activity relative to HC and HR participants in right DLPFC and precuneus for this contrast.

Bottom Line: During specific AM recall, HRs had increased activity relative to rMDDs and HCs in left ventrolateral prefrontal cortex (VLPFC) and lateral orbitofrontal cortex.During positive specific AM recall, HRs and HCs had increased activity relative to rMDDs in bilateral dorsomedial prefrontal cortex (DMPFC) and left precuneus.During negative specific AM recall HRs and HCs had increased activity in left VLPFC and right DMPFC, while rMDDs had increased activity relative to HRs and HCs in right DLPFC and precuneus.

View Article: PubMed Central - PubMed

Affiliation: Laureate Institute for Brain Research, 6655 South Yale Avenue, Tulsa, OK 74136, USA. kyoung@laureateinstitute.org.

ABSTRACT
Overgeneral autobiographical memory (AM) manifests in individuals with major depressive disorder (MDD) tested during depressed (dMDD) or remitted phases (rMDD), and healthy individuals at high-risk (HR) for developing MDD. The current study aimed to elucidate differences in hemodynamic correlates of AM recall between rMDDs, HRs, and controls (HCs) to identify neural changes following previous depressive episodes without the confound of current depressed mood. HCs, HRs, and unmedicated rMDDs (n = 20/group) underwent fMRI while recalling AMs in response to emotionally valenced cue words. HRs and rMDDs recalled fewer specific and more categorical AMs relative to HCs. During specific AM recall, HRs had increased activity relative to rMDDs and HCs in left ventrolateral prefrontal cortex (VLPFC) and lateral orbitofrontal cortex. During positive specific AM recall, HRs and HCs had increased activity relative to rMDDs in bilateral dorsomedial prefrontal cortex (DMPFC) and left precuneus. During negative specific AM recall HRs and HCs had increased activity in left VLPFC and right DMPFC, while rMDDs had increased activity relative to HRs and HCs in right DLPFC and precuneus. Differential recruitment of medial prefrontal regions implicated in emotional control suggests experiencing a depressive episode may consequently reduce one's ability to regulate emotional responses during AM recall.

No MeSH data available.


Related in: MedlinePlus