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Functional neuroimaging correlates of autobiographical memory deficits in subjects at risk for depression.

Young KD, Bellgowan PS, Bodurka J, Drevets WC - Brain Sci (2015)

Bottom Line: During specific AM recall, HRs had increased activity relative to rMDDs and HCs in left ventrolateral prefrontal cortex (VLPFC) and lateral orbitofrontal cortex.During positive specific AM recall, HRs and HCs had increased activity relative to rMDDs in bilateral dorsomedial prefrontal cortex (DMPFC) and left precuneus.During negative specific AM recall HRs and HCs had increased activity in left VLPFC and right DMPFC, while rMDDs had increased activity relative to HRs and HCs in right DLPFC and precuneus.

View Article: PubMed Central - PubMed

Affiliation: Laureate Institute for Brain Research, 6655 South Yale Avenue, Tulsa, OK 74136, USA. kyoung@laureateinstitute.org.

ABSTRACT
Overgeneral autobiographical memory (AM) manifests in individuals with major depressive disorder (MDD) tested during depressed (dMDD) or remitted phases (rMDD), and healthy individuals at high-risk (HR) for developing MDD. The current study aimed to elucidate differences in hemodynamic correlates of AM recall between rMDDs, HRs, and controls (HCs) to identify neural changes following previous depressive episodes without the confound of current depressed mood. HCs, HRs, and unmedicated rMDDs (n = 20/group) underwent fMRI while recalling AMs in response to emotionally valenced cue words. HRs and rMDDs recalled fewer specific and more categorical AMs relative to HCs. During specific AM recall, HRs had increased activity relative to rMDDs and HCs in left ventrolateral prefrontal cortex (VLPFC) and lateral orbitofrontal cortex. During positive specific AM recall, HRs and HCs had increased activity relative to rMDDs in bilateral dorsomedial prefrontal cortex (DMPFC) and left precuneus. During negative specific AM recall HRs and HCs had increased activity in left VLPFC and right DMPFC, while rMDDs had increased activity relative to HRs and HCs in right DLPFC and precuneus. Differential recruitment of medial prefrontal regions implicated in emotional control suggests experiencing a depressive episode may consequently reduce one's ability to regulate emotional responses during AM recall.

No MeSH data available.


Related in: MedlinePlus

Differences in BOLD activity between HC, HR, and rMDD groups during specific AM recall. Regions (A) left ventrolateral PFC and (B) left lateral orbitofrontal cortex are shown where group BOLD activity differed during Specific AM recall versus Example Generation (pcorrected < 0.05). Using the significant clusters in Table 3 as ROIs, beta weights were extracted for the Specific AMs versus Riser Baseline conditions, and for the Example Generation versus Riser Baseline conditions. Error bars indicate +/− one standard error of the mean. Abbreviations: AM=autobiographical memory; BOLD=blood-oxygen-level-dependent; HC = healthy control; HR = high-risk; rMDD = remitted major depressive disorder; PFC = prefrontal cortex.
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brainsci-05-00144-f001: Differences in BOLD activity between HC, HR, and rMDD groups during specific AM recall. Regions (A) left ventrolateral PFC and (B) left lateral orbitofrontal cortex are shown where group BOLD activity differed during Specific AM recall versus Example Generation (pcorrected < 0.05). Using the significant clusters in Table 3 as ROIs, beta weights were extracted for the Specific AMs versus Riser Baseline conditions, and for the Example Generation versus Riser Baseline conditions. Error bars indicate +/− one standard error of the mean. Abbreviations: AM=autobiographical memory; BOLD=blood-oxygen-level-dependent; HC = healthy control; HR = high-risk; rMDD = remitted major depressive disorder; PFC = prefrontal cortex.

Mentions: When comparing Specific Memory recall to Example Generation, BOLD activity increased in the entire sample in left medial PFC and cuneus, right VLPFC and postcentral gyrus, and bilateral DLPFC, superior temporal gyrus, middle temporal gyrus, hippocampus/parahippocampus, and precuneus. Group differences were evident in the left VLPFC and lateral OFC/BA47 such that HR participants had significantly increased BOLD activity in these regions relative to both HC and rMDD participants (Figure 1).


Functional neuroimaging correlates of autobiographical memory deficits in subjects at risk for depression.

Young KD, Bellgowan PS, Bodurka J, Drevets WC - Brain Sci (2015)

Differences in BOLD activity between HC, HR, and rMDD groups during specific AM recall. Regions (A) left ventrolateral PFC and (B) left lateral orbitofrontal cortex are shown where group BOLD activity differed during Specific AM recall versus Example Generation (pcorrected < 0.05). Using the significant clusters in Table 3 as ROIs, beta weights were extracted for the Specific AMs versus Riser Baseline conditions, and for the Example Generation versus Riser Baseline conditions. Error bars indicate +/− one standard error of the mean. Abbreviations: AM=autobiographical memory; BOLD=blood-oxygen-level-dependent; HC = healthy control; HR = high-risk; rMDD = remitted major depressive disorder; PFC = prefrontal cortex.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493461&req=5

brainsci-05-00144-f001: Differences in BOLD activity between HC, HR, and rMDD groups during specific AM recall. Regions (A) left ventrolateral PFC and (B) left lateral orbitofrontal cortex are shown where group BOLD activity differed during Specific AM recall versus Example Generation (pcorrected < 0.05). Using the significant clusters in Table 3 as ROIs, beta weights were extracted for the Specific AMs versus Riser Baseline conditions, and for the Example Generation versus Riser Baseline conditions. Error bars indicate +/− one standard error of the mean. Abbreviations: AM=autobiographical memory; BOLD=blood-oxygen-level-dependent; HC = healthy control; HR = high-risk; rMDD = remitted major depressive disorder; PFC = prefrontal cortex.
Mentions: When comparing Specific Memory recall to Example Generation, BOLD activity increased in the entire sample in left medial PFC and cuneus, right VLPFC and postcentral gyrus, and bilateral DLPFC, superior temporal gyrus, middle temporal gyrus, hippocampus/parahippocampus, and precuneus. Group differences were evident in the left VLPFC and lateral OFC/BA47 such that HR participants had significantly increased BOLD activity in these regions relative to both HC and rMDD participants (Figure 1).

Bottom Line: During specific AM recall, HRs had increased activity relative to rMDDs and HCs in left ventrolateral prefrontal cortex (VLPFC) and lateral orbitofrontal cortex.During positive specific AM recall, HRs and HCs had increased activity relative to rMDDs in bilateral dorsomedial prefrontal cortex (DMPFC) and left precuneus.During negative specific AM recall HRs and HCs had increased activity in left VLPFC and right DMPFC, while rMDDs had increased activity relative to HRs and HCs in right DLPFC and precuneus.

View Article: PubMed Central - PubMed

Affiliation: Laureate Institute for Brain Research, 6655 South Yale Avenue, Tulsa, OK 74136, USA. kyoung@laureateinstitute.org.

ABSTRACT
Overgeneral autobiographical memory (AM) manifests in individuals with major depressive disorder (MDD) tested during depressed (dMDD) or remitted phases (rMDD), and healthy individuals at high-risk (HR) for developing MDD. The current study aimed to elucidate differences in hemodynamic correlates of AM recall between rMDDs, HRs, and controls (HCs) to identify neural changes following previous depressive episodes without the confound of current depressed mood. HCs, HRs, and unmedicated rMDDs (n = 20/group) underwent fMRI while recalling AMs in response to emotionally valenced cue words. HRs and rMDDs recalled fewer specific and more categorical AMs relative to HCs. During specific AM recall, HRs had increased activity relative to rMDDs and HCs in left ventrolateral prefrontal cortex (VLPFC) and lateral orbitofrontal cortex. During positive specific AM recall, HRs and HCs had increased activity relative to rMDDs in bilateral dorsomedial prefrontal cortex (DMPFC) and left precuneus. During negative specific AM recall HRs and HCs had increased activity in left VLPFC and right DMPFC, while rMDDs had increased activity relative to HRs and HCs in right DLPFC and precuneus. Differential recruitment of medial prefrontal regions implicated in emotional control suggests experiencing a depressive episode may consequently reduce one's ability to regulate emotional responses during AM recall.

No MeSH data available.


Related in: MedlinePlus