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3,5,6,7,8,3',4'-heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus.

Okuyama S, Miyoshi K, Tsumura Y, Amakura Y, Yoshimura M, Yoshida T, Nakajima M, Furukawa Y - Brain Sci (2015)

Bottom Line: Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues.We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus.These results suggest that HMF has the ability to reduce neuroinflammation in the brain.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. sokuyama@cc.matsuyama-u.ac.jp.

ABSTRACT
Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus. These results suggest that HMF has the ability to reduce neuroinflammation in the brain.

No MeSH data available.


Related in: MedlinePlus

Effects of the subcutaneous administration of HMF on LPS-induced losses in body weight. Values are the means ± SEM. Symbols are significantly different for the following conditions: CON; control group vs. LPS, *** p < 0.001; LPS vs. LPS + HMF100, #p < 0.05.
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brainsci-05-00118-f002: Effects of the subcutaneous administration of HMF on LPS-induced losses in body weight. Values are the means ± SEM. Symbols are significantly different for the following conditions: CON; control group vs. LPS, *** p < 0.001; LPS vs. LPS + HMF100, #p < 0.05.

Mentions: In order to examine the effects of HMF on LPS-induced sickness responses, we assessed body weights two days after the injection of LPS before mice were sacrificed. As shown in Figure 2, significant body weight loss was noted in the LPS group (*** p < 0.001 vs. CON group), and the HMF treatment (100 mg/kg/day) significantly suppressed LPS-induced body weight loss (#p < 0.05 vs. LPS group).


3,5,6,7,8,3',4'-heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus.

Okuyama S, Miyoshi K, Tsumura Y, Amakura Y, Yoshimura M, Yoshida T, Nakajima M, Furukawa Y - Brain Sci (2015)

Effects of the subcutaneous administration of HMF on LPS-induced losses in body weight. Values are the means ± SEM. Symbols are significantly different for the following conditions: CON; control group vs. LPS, *** p < 0.001; LPS vs. LPS + HMF100, #p < 0.05.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493459&req=5

brainsci-05-00118-f002: Effects of the subcutaneous administration of HMF on LPS-induced losses in body weight. Values are the means ± SEM. Symbols are significantly different for the following conditions: CON; control group vs. LPS, *** p < 0.001; LPS vs. LPS + HMF100, #p < 0.05.
Mentions: In order to examine the effects of HMF on LPS-induced sickness responses, we assessed body weights two days after the injection of LPS before mice were sacrificed. As shown in Figure 2, significant body weight loss was noted in the LPS group (*** p < 0.001 vs. CON group), and the HMF treatment (100 mg/kg/day) significantly suppressed LPS-induced body weight loss (#p < 0.05 vs. LPS group).

Bottom Line: Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues.We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus.These results suggest that HMF has the ability to reduce neuroinflammation in the brain.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. sokuyama@cc.matsuyama-u.ac.jp.

ABSTRACT
Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus. These results suggest that HMF has the ability to reduce neuroinflammation in the brain.

No MeSH data available.


Related in: MedlinePlus