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Signaling during Kidney Development.

Krause M, Rak-Raszewska A, Pietilä I, Quaggin SE, Vainio S - Cells (2015)

Bottom Line: The mammalian kidney function depends on the coordinated development of specific cell types within a precise architectural framework.Due to the availability of modern analysis techniques, the kidney has become a model organ defining the paradigm to study organogenesis.As kidney diseases are a problem worldwide, the understanding of mammalian kidney cells is of crucial importance to develop diagnostic tools and novel therapies.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, Oulu University, 90014 Oulu, Finland. mirja.krause@oulu.fi.

ABSTRACT
The kidney plays an essential role during excretion of metabolic waste products, maintenance of key homeostasis components such as ion concentrations and hormone levels. It influences the blood pressure, composition and volume. The kidney tubule system is composed of two distinct cell populations: the nephrons forming the filtering units and the collecting duct system derived from the ureteric bud. Nephrons are composed of glomeruli that filter the blood to the Bowman's capsule and tubular structures that reabsorb and concentrate primary urine. The collecting duct is a Wolffian duct-derived epithelial tube that concentrates and collects urine and transfers it via the renal pelvis into the bladder. The mammalian kidney function depends on the coordinated development of specific cell types within a precise architectural framework. Due to the availability of modern analysis techniques, the kidney has become a model organ defining the paradigm to study organogenesis. As kidney diseases are a problem worldwide, the understanding of mammalian kidney cells is of crucial importance to develop diagnostic tools and novel therapies. This review focuses on how the pattern of renal development is generated, how the inductive signals are regulated and what are their effects on proliferation, differentiation and morphogenesis.

No MeSH data available.


Related in: MedlinePlus

Structure and organization of the kidney. (A) The location of the kidney in the body; (B) Schematic cross section of the kidney to demonstrate the overall structure; (C) A closer look gives an insight on the nephron structure and orientation within the kidney with a clear distinction between the cortex and the medulla.
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cells-04-00112-f001: Structure and organization of the kidney. (A) The location of the kidney in the body; (B) Schematic cross section of the kidney to demonstrate the overall structure; (C) A closer look gives an insight on the nephron structure and orientation within the kidney with a clear distinction between the cortex and the medulla.

Mentions: The kidney coordinates homeostasis in many ways. It regulates the effective blood volume and blood pressure via the renin-angiotensin system, and the excretion and uptake of plasma components, and the pH-balance of the body [1]. An overview of the kidney location in the body, the structure of the adult kidney can be seen in Figure 1. The key functional unit of the kidney is the nephron which develops from the resident progenitor/stem cells by a Wnt-signaling process as shown by our lab and others in the past [1,2,3,4].


Signaling during Kidney Development.

Krause M, Rak-Raszewska A, Pietilä I, Quaggin SE, Vainio S - Cells (2015)

Structure and organization of the kidney. (A) The location of the kidney in the body; (B) Schematic cross section of the kidney to demonstrate the overall structure; (C) A closer look gives an insight on the nephron structure and orientation within the kidney with a clear distinction between the cortex and the medulla.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493451&req=5

cells-04-00112-f001: Structure and organization of the kidney. (A) The location of the kidney in the body; (B) Schematic cross section of the kidney to demonstrate the overall structure; (C) A closer look gives an insight on the nephron structure and orientation within the kidney with a clear distinction between the cortex and the medulla.
Mentions: The kidney coordinates homeostasis in many ways. It regulates the effective blood volume and blood pressure via the renin-angiotensin system, and the excretion and uptake of plasma components, and the pH-balance of the body [1]. An overview of the kidney location in the body, the structure of the adult kidney can be seen in Figure 1. The key functional unit of the kidney is the nephron which develops from the resident progenitor/stem cells by a Wnt-signaling process as shown by our lab and others in the past [1,2,3,4].

Bottom Line: The mammalian kidney function depends on the coordinated development of specific cell types within a precise architectural framework.Due to the availability of modern analysis techniques, the kidney has become a model organ defining the paradigm to study organogenesis.As kidney diseases are a problem worldwide, the understanding of mammalian kidney cells is of crucial importance to develop diagnostic tools and novel therapies.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, Oulu University, 90014 Oulu, Finland. mirja.krause@oulu.fi.

ABSTRACT
The kidney plays an essential role during excretion of metabolic waste products, maintenance of key homeostasis components such as ion concentrations and hormone levels. It influences the blood pressure, composition and volume. The kidney tubule system is composed of two distinct cell populations: the nephrons forming the filtering units and the collecting duct system derived from the ureteric bud. Nephrons are composed of glomeruli that filter the blood to the Bowman's capsule and tubular structures that reabsorb and concentrate primary urine. The collecting duct is a Wolffian duct-derived epithelial tube that concentrates and collects urine and transfers it via the renal pelvis into the bladder. The mammalian kidney function depends on the coordinated development of specific cell types within a precise architectural framework. Due to the availability of modern analysis techniques, the kidney has become a model organ defining the paradigm to study organogenesis. As kidney diseases are a problem worldwide, the understanding of mammalian kidney cells is of crucial importance to develop diagnostic tools and novel therapies. This review focuses on how the pattern of renal development is generated, how the inductive signals are regulated and what are their effects on proliferation, differentiation and morphogenesis.

No MeSH data available.


Related in: MedlinePlus