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NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis.

Santillo M, Colantuoni A, Mondola P, Guida B, Damiano S - Front Physiol (2015)

Bottom Line: Blood pressure homeostasis is maintained by several mechanisms regulating cardiac output, vascular resistances, and blood volume.NOXs exert a central role in cardiac mechanosensing, endothelium-dependent relaxation, and Angiotensin-II (Ang-II) redox signaling regulating vascular tone.The central role of NOXs in redox-dependent cardiovascular cell functions renders these enzymes a promising pharmacological target for the treatment of cardiovascular diseases, including hypertension.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli "Federico II" Naples, Italy.

ABSTRACT
Blood pressure homeostasis is maintained by several mechanisms regulating cardiac output, vascular resistances, and blood volume. At cellular levels, reactive oxygen species (ROS) signaling is involved in multiple molecular mechanisms controlling blood pressure. Among ROS producing systems, NADPH oxidases (NOXs), expressed in different cells of the cardiovascular system, are the most important enzymes clearly linked to the development of hypertension. NOXs exert a central role in cardiac mechanosensing, endothelium-dependent relaxation, and Angiotensin-II (Ang-II) redox signaling regulating vascular tone. The central role of NOXs in redox-dependent cardiovascular cell functions renders these enzymes a promising pharmacological target for the treatment of cardiovascular diseases, including hypertension. The aim of the present review is to focus on the physiological role of the cardiovascular NOX-generating ROS in the molecular and cellular mechanisms affecting blood pressure.

No MeSH data available.


Related in: MedlinePlus

Scheme of the main NOXs-dependent cardiovascular mechanisms involved in the control of blood pressure. RyR2, Ryanodine Receptor type 2; ET-1, endothelin-1; NA, noradrenaline; AT1r, Angiotensin I type 1 receptor; ET1, endothelin 1; ETAR, Endothelin type A receptor; NHE-1, Na+/H+ exchanger-1; NCX, Na+/Ca2+ exchanger; e-NOS, endothelial nitric oxide synthase.
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Figure 2: Scheme of the main NOXs-dependent cardiovascular mechanisms involved in the control of blood pressure. RyR2, Ryanodine Receptor type 2; ET-1, endothelin-1; NA, noradrenaline; AT1r, Angiotensin I type 1 receptor; ET1, endothelin 1; ETAR, Endothelin type A receptor; NHE-1, Na+/H+ exchanger-1; NCX, Na+/Ca2+ exchanger; e-NOS, endothelial nitric oxide synthase.

Mentions: Multiple molecular mechanisms regulating blood pressure involve NOX signaling. Of great importance is the central role of NOXs in angiotensin signaling, in the availability of NO and in the cardiac mechanosensing. A general scheme of the main overall effects of NOX-mediated signaling in the cells of the cardiovascular system leading to blood pressure modulation are shown in Figure 2.


NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis.

Santillo M, Colantuoni A, Mondola P, Guida B, Damiano S - Front Physiol (2015)

Scheme of the main NOXs-dependent cardiovascular mechanisms involved in the control of blood pressure. RyR2, Ryanodine Receptor type 2; ET-1, endothelin-1; NA, noradrenaline; AT1r, Angiotensin I type 1 receptor; ET1, endothelin 1; ETAR, Endothelin type A receptor; NHE-1, Na+/H+ exchanger-1; NCX, Na+/Ca2+ exchanger; e-NOS, endothelial nitric oxide synthase.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493385&req=5

Figure 2: Scheme of the main NOXs-dependent cardiovascular mechanisms involved in the control of blood pressure. RyR2, Ryanodine Receptor type 2; ET-1, endothelin-1; NA, noradrenaline; AT1r, Angiotensin I type 1 receptor; ET1, endothelin 1; ETAR, Endothelin type A receptor; NHE-1, Na+/H+ exchanger-1; NCX, Na+/Ca2+ exchanger; e-NOS, endothelial nitric oxide synthase.
Mentions: Multiple molecular mechanisms regulating blood pressure involve NOX signaling. Of great importance is the central role of NOXs in angiotensin signaling, in the availability of NO and in the cardiac mechanosensing. A general scheme of the main overall effects of NOX-mediated signaling in the cells of the cardiovascular system leading to blood pressure modulation are shown in Figure 2.

Bottom Line: Blood pressure homeostasis is maintained by several mechanisms regulating cardiac output, vascular resistances, and blood volume.NOXs exert a central role in cardiac mechanosensing, endothelium-dependent relaxation, and Angiotensin-II (Ang-II) redox signaling regulating vascular tone.The central role of NOXs in redox-dependent cardiovascular cell functions renders these enzymes a promising pharmacological target for the treatment of cardiovascular diseases, including hypertension.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli "Federico II" Naples, Italy.

ABSTRACT
Blood pressure homeostasis is maintained by several mechanisms regulating cardiac output, vascular resistances, and blood volume. At cellular levels, reactive oxygen species (ROS) signaling is involved in multiple molecular mechanisms controlling blood pressure. Among ROS producing systems, NADPH oxidases (NOXs), expressed in different cells of the cardiovascular system, are the most important enzymes clearly linked to the development of hypertension. NOXs exert a central role in cardiac mechanosensing, endothelium-dependent relaxation, and Angiotensin-II (Ang-II) redox signaling regulating vascular tone. The central role of NOXs in redox-dependent cardiovascular cell functions renders these enzymes a promising pharmacological target for the treatment of cardiovascular diseases, including hypertension. The aim of the present review is to focus on the physiological role of the cardiovascular NOX-generating ROS in the molecular and cellular mechanisms affecting blood pressure.

No MeSH data available.


Related in: MedlinePlus