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Dissecting metabolic syndrome components: data from an epidemiologic survey in a genetic isolate.

Biino G, Concas MP, Cena H, Parracciani D, Vaccargiu S, Cosso M, Marras F, D'Esposito V, Beguinot F, Pirastu M - Springerplus (2015)

Bottom Line: Heritability was determined using variance component models.The most prevalent combination was BP + HDL-cholesterol (HDL) + triglycerides (TRIG) (19%), followed by BP + HDL + waist circumference (WAIST) (17%) and, BP + HDL + TRIG + WAIST (13.6%).Besides, further studies are warranted to confirm these findings both in isolated and outbred populations.

View Article: PubMed Central - PubMed

Affiliation: Institute of Molecular Genetics-CNR, National Research Council of Italy, Via Abbiategrasso 207, 27100 Pavia, Italy.

ABSTRACT
The metabolic syndrome (MetS) is a large-scale and expanding public-health and clinical threat worldwide. We investigated the determinants of MetS, assessed its prevalence and components and, estimated their genetic contribution, taking advantage of the special characteristics of Sardinian isolated populations. Inhabitants of 10 villages in Ogliastra region participated in a cross-sectional survey in 2002-2008 (n = 9,647). Blood samples, blood pressure (BP), anthropometry and, data from a standardized interview were collected. Prevalence of MetS was estimated by the direct method of standardization. Variables associated with the MetS were identified using multilevel logistic regression. Heritability was determined using variance component models. MetS Prevalence was 19.6% (95% CI 18.9-20.4%) according to NCEP-ATPIII, 24.8% (95% CI 24.0-25.6%) according to IDF and, 29% (95% CI 28.1-29.8%) according to AHA/NHLBI harmonized criteria, ranging from 9 to 26% among villages. The most prevalent combination was BP + HDL-cholesterol (HDL) + triglycerides (TRIG) (19%), followed by BP + HDL + waist circumference (WAIST) (17%) and, BP + HDL + TRIG + WAIST (13.6%). Heritability of MetS was 48% (p = 1.62 × 10(-25)), as the two most common combinations (BP + HDL + TRIG and BP + HDL + WAIST) showed heritability of 53 and 52%, respectively. The larger genetic components of the two most frequent combinations determining MetS deserve greater investigation in order to understand the underlying mechanisms. Besides, further studies are warranted to confirm these findings both in isolated and outbred populations.

No MeSH data available.


Related in: MedlinePlus

Prevalence of MetS components’ combinations by village. Bars are 95% CI. Percentages in brackets represent prevalence of specific combinations over subjects affected by MetS. Prevalences on y axis are computed over the entire sample adjusting for age and sex.
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Fig2: Prevalence of MetS components’ combinations by village. Bars are 95% CI. Percentages in brackets represent prevalence of specific combinations over subjects affected by MetS. Prevalences on y axis are computed over the entire sample adjusting for age and sex.

Mentions: We investigated which components combination contributed most to the diagnosis of MetS. Table 2 shows the distribution of affected subjects by all possible combinations of components. The most prevalent combination is BP + HDL + TRIG (19%), characterizing about one-third of men. The second one is BP + HDL + WAIST (17%), representing about one-fourth of women, and the third one is BP + HDL + TRIG + WAIST (13.6%). For some of the combinations there is a statistically significant difference between men and women, in particular MetS in women appears more influenced by the waist component as MetS in men looks more influenced by the triglyceridemia and glycaemia components. Interestingly, for the most frequent combinations, statistically significant differences were observed among villages, even after adjusting for age and sex: in villages where the BP + HDL + TRIG combination was the most prevalent, the BP + HDL + WAIST was the less prevalent (Figure 2) and vice versa.Table 2


Dissecting metabolic syndrome components: data from an epidemiologic survey in a genetic isolate.

Biino G, Concas MP, Cena H, Parracciani D, Vaccargiu S, Cosso M, Marras F, D'Esposito V, Beguinot F, Pirastu M - Springerplus (2015)

Prevalence of MetS components’ combinations by village. Bars are 95% CI. Percentages in brackets represent prevalence of specific combinations over subjects affected by MetS. Prevalences on y axis are computed over the entire sample adjusting for age and sex.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493262&req=5

Fig2: Prevalence of MetS components’ combinations by village. Bars are 95% CI. Percentages in brackets represent prevalence of specific combinations over subjects affected by MetS. Prevalences on y axis are computed over the entire sample adjusting for age and sex.
Mentions: We investigated which components combination contributed most to the diagnosis of MetS. Table 2 shows the distribution of affected subjects by all possible combinations of components. The most prevalent combination is BP + HDL + TRIG (19%), characterizing about one-third of men. The second one is BP + HDL + WAIST (17%), representing about one-fourth of women, and the third one is BP + HDL + TRIG + WAIST (13.6%). For some of the combinations there is a statistically significant difference between men and women, in particular MetS in women appears more influenced by the waist component as MetS in men looks more influenced by the triglyceridemia and glycaemia components. Interestingly, for the most frequent combinations, statistically significant differences were observed among villages, even after adjusting for age and sex: in villages where the BP + HDL + TRIG combination was the most prevalent, the BP + HDL + WAIST was the less prevalent (Figure 2) and vice versa.Table 2

Bottom Line: Heritability was determined using variance component models.The most prevalent combination was BP + HDL-cholesterol (HDL) + triglycerides (TRIG) (19%), followed by BP + HDL + waist circumference (WAIST) (17%) and, BP + HDL + TRIG + WAIST (13.6%).Besides, further studies are warranted to confirm these findings both in isolated and outbred populations.

View Article: PubMed Central - PubMed

Affiliation: Institute of Molecular Genetics-CNR, National Research Council of Italy, Via Abbiategrasso 207, 27100 Pavia, Italy.

ABSTRACT
The metabolic syndrome (MetS) is a large-scale and expanding public-health and clinical threat worldwide. We investigated the determinants of MetS, assessed its prevalence and components and, estimated their genetic contribution, taking advantage of the special characteristics of Sardinian isolated populations. Inhabitants of 10 villages in Ogliastra region participated in a cross-sectional survey in 2002-2008 (n = 9,647). Blood samples, blood pressure (BP), anthropometry and, data from a standardized interview were collected. Prevalence of MetS was estimated by the direct method of standardization. Variables associated with the MetS were identified using multilevel logistic regression. Heritability was determined using variance component models. MetS Prevalence was 19.6% (95% CI 18.9-20.4%) according to NCEP-ATPIII, 24.8% (95% CI 24.0-25.6%) according to IDF and, 29% (95% CI 28.1-29.8%) according to AHA/NHLBI harmonized criteria, ranging from 9 to 26% among villages. The most prevalent combination was BP + HDL-cholesterol (HDL) + triglycerides (TRIG) (19%), followed by BP + HDL + waist circumference (WAIST) (17%) and, BP + HDL + TRIG + WAIST (13.6%). Heritability of MetS was 48% (p = 1.62 × 10(-25)), as the two most common combinations (BP + HDL + TRIG and BP + HDL + WAIST) showed heritability of 53 and 52%, respectively. The larger genetic components of the two most frequent combinations determining MetS deserve greater investigation in order to understand the underlying mechanisms. Besides, further studies are warranted to confirm these findings both in isolated and outbred populations.

No MeSH data available.


Related in: MedlinePlus