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Dissecting metabolic syndrome components: data from an epidemiologic survey in a genetic isolate.

Biino G, Concas MP, Cena H, Parracciani D, Vaccargiu S, Cosso M, Marras F, D'Esposito V, Beguinot F, Pirastu M - Springerplus (2015)

Bottom Line: Heritability was determined using variance component models.The most prevalent combination was BP + HDL-cholesterol (HDL) + triglycerides (TRIG) (19%), followed by BP + HDL + waist circumference (WAIST) (17%) and, BP + HDL + TRIG + WAIST (13.6%).Besides, further studies are warranted to confirm these findings both in isolated and outbred populations.

View Article: PubMed Central - PubMed

Affiliation: Institute of Molecular Genetics-CNR, National Research Council of Italy, Via Abbiategrasso 207, 27100 Pavia, Italy.

ABSTRACT
The metabolic syndrome (MetS) is a large-scale and expanding public-health and clinical threat worldwide. We investigated the determinants of MetS, assessed its prevalence and components and, estimated their genetic contribution, taking advantage of the special characteristics of Sardinian isolated populations. Inhabitants of 10 villages in Ogliastra region participated in a cross-sectional survey in 2002-2008 (n = 9,647). Blood samples, blood pressure (BP), anthropometry and, data from a standardized interview were collected. Prevalence of MetS was estimated by the direct method of standardization. Variables associated with the MetS were identified using multilevel logistic regression. Heritability was determined using variance component models. MetS Prevalence was 19.6% (95% CI 18.9-20.4%) according to NCEP-ATPIII, 24.8% (95% CI 24.0-25.6%) according to IDF and, 29% (95% CI 28.1-29.8%) according to AHA/NHLBI harmonized criteria, ranging from 9 to 26% among villages. The most prevalent combination was BP + HDL-cholesterol (HDL) + triglycerides (TRIG) (19%), followed by BP + HDL + waist circumference (WAIST) (17%) and, BP + HDL + TRIG + WAIST (13.6%). Heritability of MetS was 48% (p = 1.62 × 10(-25)), as the two most common combinations (BP + HDL + TRIG and BP + HDL + WAIST) showed heritability of 53 and 52%, respectively. The larger genetic components of the two most frequent combinations determining MetS deserve greater investigation in order to understand the underlying mechanisms. Besides, further studies are warranted to confirm these findings both in isolated and outbred populations.

No MeSH data available.


Related in: MedlinePlus

Prevalence of the metabolic syndrome by village according to NCEP-ATPIII. Bars are 95% CI.
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Fig1: Prevalence of the metabolic syndrome by village according to NCEP-ATPIII. Bars are 95% CI.

Mentions: Standardized prevalence of MetS was 19.6% (NCEP-ATPIII, 95% CI 18.9–20.4%), 24.8% (IDF, 95% CI 24.0–25.6%) and, 29% (IDF and AHA/NHLBI, 95% CI 28.1–29.8%), with a statistically significant difference between men and women (31.8 vs 26.4%). Since the ten villages represent genetic isolates with peculiar founder populations and almost no migration or exchanges amongst them for many centuries up to 30 years ago, prevalence of MetS was estimated separately (NCEP-ATPIII, Figure 1). In some of the villages age- and sex-adjusted prevalence was significantly higher or lower than the average value, ranging from 9 to 26%.Figure 1


Dissecting metabolic syndrome components: data from an epidemiologic survey in a genetic isolate.

Biino G, Concas MP, Cena H, Parracciani D, Vaccargiu S, Cosso M, Marras F, D'Esposito V, Beguinot F, Pirastu M - Springerplus (2015)

Prevalence of the metabolic syndrome by village according to NCEP-ATPIII. Bars are 95% CI.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493262&req=5

Fig1: Prevalence of the metabolic syndrome by village according to NCEP-ATPIII. Bars are 95% CI.
Mentions: Standardized prevalence of MetS was 19.6% (NCEP-ATPIII, 95% CI 18.9–20.4%), 24.8% (IDF, 95% CI 24.0–25.6%) and, 29% (IDF and AHA/NHLBI, 95% CI 28.1–29.8%), with a statistically significant difference between men and women (31.8 vs 26.4%). Since the ten villages represent genetic isolates with peculiar founder populations and almost no migration or exchanges amongst them for many centuries up to 30 years ago, prevalence of MetS was estimated separately (NCEP-ATPIII, Figure 1). In some of the villages age- and sex-adjusted prevalence was significantly higher or lower than the average value, ranging from 9 to 26%.Figure 1

Bottom Line: Heritability was determined using variance component models.The most prevalent combination was BP + HDL-cholesterol (HDL) + triglycerides (TRIG) (19%), followed by BP + HDL + waist circumference (WAIST) (17%) and, BP + HDL + TRIG + WAIST (13.6%).Besides, further studies are warranted to confirm these findings both in isolated and outbred populations.

View Article: PubMed Central - PubMed

Affiliation: Institute of Molecular Genetics-CNR, National Research Council of Italy, Via Abbiategrasso 207, 27100 Pavia, Italy.

ABSTRACT
The metabolic syndrome (MetS) is a large-scale and expanding public-health and clinical threat worldwide. We investigated the determinants of MetS, assessed its prevalence and components and, estimated their genetic contribution, taking advantage of the special characteristics of Sardinian isolated populations. Inhabitants of 10 villages in Ogliastra region participated in a cross-sectional survey in 2002-2008 (n = 9,647). Blood samples, blood pressure (BP), anthropometry and, data from a standardized interview were collected. Prevalence of MetS was estimated by the direct method of standardization. Variables associated with the MetS were identified using multilevel logistic regression. Heritability was determined using variance component models. MetS Prevalence was 19.6% (95% CI 18.9-20.4%) according to NCEP-ATPIII, 24.8% (95% CI 24.0-25.6%) according to IDF and, 29% (95% CI 28.1-29.8%) according to AHA/NHLBI harmonized criteria, ranging from 9 to 26% among villages. The most prevalent combination was BP + HDL-cholesterol (HDL) + triglycerides (TRIG) (19%), followed by BP + HDL + waist circumference (WAIST) (17%) and, BP + HDL + TRIG + WAIST (13.6%). Heritability of MetS was 48% (p = 1.62 × 10(-25)), as the two most common combinations (BP + HDL + TRIG and BP + HDL + WAIST) showed heritability of 53 and 52%, respectively. The larger genetic components of the two most frequent combinations determining MetS deserve greater investigation in order to understand the underlying mechanisms. Besides, further studies are warranted to confirm these findings both in isolated and outbred populations.

No MeSH data available.


Related in: MedlinePlus