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Differences in Clinical and Laboratory Findings between Group D and Non-Group D Non-Typhoidal Salmonella Gastroenteritis in Children.

Park HK, Rhie K, Yeom JS, Park JS, Park ES, Seo JH, Lim JY, Park CH, Woo HO, Youn HS, Kang KR, Park JJ - Pediatr Gastroenterol Hepatol Nutr (2015)

Bottom Line: A positive Widal test result was observed in 53.3% of group D and 6.7% of non-group D NTS cases (O-titer, p=0.030; H-titer, p=0.039).The more severe clinical features such as headache, fever, and higher Widal titers were found to be indicative of group D NTS gastroenteritis.Additionally, group D NTS gastroenteritis was more commonly found in older patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.

ABSTRACT

Purpose: To investigate the differences in clinical features and laboratory findings between group D and non-group D non-typhoidal Salmonella (NTS) gastroenteritis in children.

Methods: A retrospective chart review of children diagnosed with NTS confirmed by culture study was performed. The clinical features and laboratory findings of group D and non-group D NTS were compared.

Results: From 2003 to 2012, 75 cases were diagnosed as NTS at our center. The number of group D and non-group D patients was 45 and 30, respectively. The mean age was higher in group D than in non-group D patients (5.1 years vs. 3.4 years, p=0.038). Headaches were more frequently observed (p=0.046) and hematochezia was less frequently observed (p=0.017) in group D than in non-group D NTS gastroenteritis patients. A positive Widal test result was observed in 53.3% of group D and 6.7% of non-group D NTS cases (O-titer, p=0.030; H-titer, p=0.039). There were no differences in white blood cell counts, level of C-reactive protein and rate of antimicrobial resistance between group D and non-group D cases.

Conclusion: The more severe clinical features such as headache, fever, and higher Widal titers were found to be indicative of group D NTS gastroenteritis. Additionally, group D NTS gastroenteritis was more commonly found in older patients. Therefore, old age, fever, headache, and a positive Widal test are more indicative of group D NTS than non-group D NTS gastroenteritis. Pathophysiological mechanisms may differ across serologic groups.

No MeSH data available.


Related in: MedlinePlus

Number of group D and non-group D non-typhoidal Salmonella gastroenteritis patients according to age. The peak occurrence was observed in children aged 2 and 3 years old in both groups. In children under the age of 5, there were more non-group D cases than group D cases.
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Figure 3: Number of group D and non-group D non-typhoidal Salmonella gastroenteritis patients according to age. The peak occurrence was observed in children aged 2 and 3 years old in both groups. In children under the age of 5, there were more non-group D cases than group D cases.

Mentions: The population age proportions of <1 year, 1-5 years, 6-10 years, and 11-15 years were 12.0% (9/75), 60.0% (45/75), 13.3% (10/75) and 14.7% (11/75), respectively (Fig. 3). The mean age was 4.4 years (range: 0-15 years). The male-to-female ratio was 1:1 (49.3% and 50.7%). None of the patients had a previous history of chronic disease or malignancy before the episode of NTS gastroenteritis. All patients had diarrhea and 94.7% of patients had fever. Other symptoms included abdominal pain (57.0%), hematochezia (25.3%) and headache (17.3%). There was no pneumonia, arthritis, or meningitis present in any patient. All patients were managed with oral or intravenous antimicrobial agents (third-generation cephalosporins) and discharged in good general condition.


Differences in Clinical and Laboratory Findings between Group D and Non-Group D Non-Typhoidal Salmonella Gastroenteritis in Children.

Park HK, Rhie K, Yeom JS, Park JS, Park ES, Seo JH, Lim JY, Park CH, Woo HO, Youn HS, Kang KR, Park JJ - Pediatr Gastroenterol Hepatol Nutr (2015)

Number of group D and non-group D non-typhoidal Salmonella gastroenteritis patients according to age. The peak occurrence was observed in children aged 2 and 3 years old in both groups. In children under the age of 5, there were more non-group D cases than group D cases.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493251&req=5

Figure 3: Number of group D and non-group D non-typhoidal Salmonella gastroenteritis patients according to age. The peak occurrence was observed in children aged 2 and 3 years old in both groups. In children under the age of 5, there were more non-group D cases than group D cases.
Mentions: The population age proportions of <1 year, 1-5 years, 6-10 years, and 11-15 years were 12.0% (9/75), 60.0% (45/75), 13.3% (10/75) and 14.7% (11/75), respectively (Fig. 3). The mean age was 4.4 years (range: 0-15 years). The male-to-female ratio was 1:1 (49.3% and 50.7%). None of the patients had a previous history of chronic disease or malignancy before the episode of NTS gastroenteritis. All patients had diarrhea and 94.7% of patients had fever. Other symptoms included abdominal pain (57.0%), hematochezia (25.3%) and headache (17.3%). There was no pneumonia, arthritis, or meningitis present in any patient. All patients were managed with oral or intravenous antimicrobial agents (third-generation cephalosporins) and discharged in good general condition.

Bottom Line: A positive Widal test result was observed in 53.3% of group D and 6.7% of non-group D NTS cases (O-titer, p=0.030; H-titer, p=0.039).The more severe clinical features such as headache, fever, and higher Widal titers were found to be indicative of group D NTS gastroenteritis.Additionally, group D NTS gastroenteritis was more commonly found in older patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.

ABSTRACT

Purpose: To investigate the differences in clinical features and laboratory findings between group D and non-group D non-typhoidal Salmonella (NTS) gastroenteritis in children.

Methods: A retrospective chart review of children diagnosed with NTS confirmed by culture study was performed. The clinical features and laboratory findings of group D and non-group D NTS were compared.

Results: From 2003 to 2012, 75 cases were diagnosed as NTS at our center. The number of group D and non-group D patients was 45 and 30, respectively. The mean age was higher in group D than in non-group D patients (5.1 years vs. 3.4 years, p=0.038). Headaches were more frequently observed (p=0.046) and hematochezia was less frequently observed (p=0.017) in group D than in non-group D NTS gastroenteritis patients. A positive Widal test result was observed in 53.3% of group D and 6.7% of non-group D NTS cases (O-titer, p=0.030; H-titer, p=0.039). There were no differences in white blood cell counts, level of C-reactive protein and rate of antimicrobial resistance between group D and non-group D cases.

Conclusion: The more severe clinical features such as headache, fever, and higher Widal titers were found to be indicative of group D NTS gastroenteritis. Additionally, group D NTS gastroenteritis was more commonly found in older patients. Therefore, old age, fever, headache, and a positive Widal test are more indicative of group D NTS than non-group D NTS gastroenteritis. Pathophysiological mechanisms may differ across serologic groups.

No MeSH data available.


Related in: MedlinePlus