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Atypical β-Catenin Activated Child Hepatocellular Tumor.

Turan A, Unlu HA, Karakus E, Yazal Erdem A, Yakut ZI - Pediatr Gastroenterol Hepatol Nutr (2015)

Bottom Line: Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features.The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child.In this case, atypical diffuse steatosis was determined in the lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

ABSTRACT
Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The β-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular adenomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-1α-inactivated hepatocellular adenomas subtype, has not been previously reported in any β-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.

No MeSH data available.


Related in: MedlinePlus

(A) Macroscopically, a tumoral lesion showing a nodular growth pattern with large and small many nodulations in the cut surface. (B) Microscopically, the tumor cells were pleomorphic with large, transparent cytoplasm and hyperchromatic nuclei showing prominent nucleoli (H&E, ×100).
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Figure 5: (A) Macroscopically, a tumoral lesion showing a nodular growth pattern with large and small many nodulations in the cut surface. (B) Microscopically, the tumor cells were pleomorphic with large, transparent cytoplasm and hyperchromatic nuclei showing prominent nucleoli (H&E, ×100).

Mentions: Thus the lesion was totally excised. The macroscopic evaluation of the right hepatectomy material revealed tumoral lesion, measuring 13×9×6 cm, with irregular borders, showing nodular growth patterns, and numerous large and small nodulations in cut surface were observed (Fig. 5A). Microscopically, the tumor was separated into nodule formations with fibrous septae and contained hemorrhagic areas, secondary to the treatment, cholesterol clefts and dense histiocytic areas. The tumor contained pleomorphic cells with large, transparent cytoplasm and hyperchromatic nuclei showing prominent nucleoli (Fig. 5B). In the immunohistochemical evaluation, the tumor cells were positive for HCC, glypican 3, CD10, and carcinoembryonic antigen. There was a focal positivity with beta catenin. With these findings, the lesion was regarded as well a differentiated HCC.


Atypical β-Catenin Activated Child Hepatocellular Tumor.

Turan A, Unlu HA, Karakus E, Yazal Erdem A, Yakut ZI - Pediatr Gastroenterol Hepatol Nutr (2015)

(A) Macroscopically, a tumoral lesion showing a nodular growth pattern with large and small many nodulations in the cut surface. (B) Microscopically, the tumor cells were pleomorphic with large, transparent cytoplasm and hyperchromatic nuclei showing prominent nucleoli (H&E, ×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493249&req=5

Figure 5: (A) Macroscopically, a tumoral lesion showing a nodular growth pattern with large and small many nodulations in the cut surface. (B) Microscopically, the tumor cells were pleomorphic with large, transparent cytoplasm and hyperchromatic nuclei showing prominent nucleoli (H&E, ×100).
Mentions: Thus the lesion was totally excised. The macroscopic evaluation of the right hepatectomy material revealed tumoral lesion, measuring 13×9×6 cm, with irregular borders, showing nodular growth patterns, and numerous large and small nodulations in cut surface were observed (Fig. 5A). Microscopically, the tumor was separated into nodule formations with fibrous septae and contained hemorrhagic areas, secondary to the treatment, cholesterol clefts and dense histiocytic areas. The tumor contained pleomorphic cells with large, transparent cytoplasm and hyperchromatic nuclei showing prominent nucleoli (Fig. 5B). In the immunohistochemical evaluation, the tumor cells were positive for HCC, glypican 3, CD10, and carcinoembryonic antigen. There was a focal positivity with beta catenin. With these findings, the lesion was regarded as well a differentiated HCC.

Bottom Line: Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features.The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child.In this case, atypical diffuse steatosis was determined in the lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

ABSTRACT
Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The β-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular adenomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-1α-inactivated hepatocellular adenomas subtype, has not been previously reported in any β-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.

No MeSH data available.


Related in: MedlinePlus