Limits...
Atypical β-Catenin Activated Child Hepatocellular Tumor.

Turan A, Unlu HA, Karakus E, Yazal Erdem A, Yakut ZI - Pediatr Gastroenterol Hepatol Nutr (2015)

Bottom Line: Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features.The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child.In this case, atypical diffuse steatosis was determined in the lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

ABSTRACT
Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The β-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular adenomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-1α-inactivated hepatocellular adenomas subtype, has not been previously reported in any β-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.

No MeSH data available.


Related in: MedlinePlus

In the T2-weighted (A) coronal and (B) axial images, a central scar (arrow) present in the lesion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4493249&req=5

Figure 3: In the T2-weighted (A) coronal and (B) axial images, a central scar (arrow) present in the lesion.

Mentions: The abdominal MRI revealed a lobulated liver lesion, affecting V and VIsegments which was measured 14×15×18 cm. The lesion was hyperintense in axial in-phase gradient echo sequences (GRE) T1-weighted images (T1WI) while in out-of-phase chemical shift GRE T1WI lesion demonstrated signal drop out confirming intracellular lipid content (Fig. 2). The lesion was hyperintense in coronal T2WI (Fig. 3A) and contained a hyperintense central scar with indefinite septate formations in fat saturated T2WI (Fig. 3B). In contrast-enhanced study with gadobenate dimeglumine (Gd-BOPTA), the lesion had slightly heterogeneous contrast enhancement in the arterial phase prominent in septates. It was also noted that the contrast enhancement in the septates became more evident in portal venous phase. A long side with septate enhancement, the central scar was considerably enhanced in the hepatobiliary phase taken at the first hour (Fig. 4). Lipid containing areas of the tumor did not show significant contrast enhancement throughout all phases. Contast wash-out of tumor wasn't detected in any phase.


Atypical β-Catenin Activated Child Hepatocellular Tumor.

Turan A, Unlu HA, Karakus E, Yazal Erdem A, Yakut ZI - Pediatr Gastroenterol Hepatol Nutr (2015)

In the T2-weighted (A) coronal and (B) axial images, a central scar (arrow) present in the lesion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493249&req=5

Figure 3: In the T2-weighted (A) coronal and (B) axial images, a central scar (arrow) present in the lesion.
Mentions: The abdominal MRI revealed a lobulated liver lesion, affecting V and VIsegments which was measured 14×15×18 cm. The lesion was hyperintense in axial in-phase gradient echo sequences (GRE) T1-weighted images (T1WI) while in out-of-phase chemical shift GRE T1WI lesion demonstrated signal drop out confirming intracellular lipid content (Fig. 2). The lesion was hyperintense in coronal T2WI (Fig. 3A) and contained a hyperintense central scar with indefinite septate formations in fat saturated T2WI (Fig. 3B). In contrast-enhanced study with gadobenate dimeglumine (Gd-BOPTA), the lesion had slightly heterogeneous contrast enhancement in the arterial phase prominent in septates. It was also noted that the contrast enhancement in the septates became more evident in portal venous phase. A long side with septate enhancement, the central scar was considerably enhanced in the hepatobiliary phase taken at the first hour (Fig. 4). Lipid containing areas of the tumor did not show significant contrast enhancement throughout all phases. Contast wash-out of tumor wasn't detected in any phase.

Bottom Line: Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features.The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child.In this case, atypical diffuse steatosis was determined in the lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

ABSTRACT
Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The β-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular adenomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-1α-inactivated hepatocellular adenomas subtype, has not been previously reported in any β-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.

No MeSH data available.


Related in: MedlinePlus