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A highlight from the LUPUS 2014 meeting: eight great ideas.

Buyon JP, Cohen P, Merrill JT, Gilkeson G, Kaplan M, James J, McCune WJ, Bernatsky S, Elkon K - Lupus Sci Med (2015)

Bottom Line: This review describes eight 'great ideas' regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014.The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatology, Department of Medicine , NYU School of Medicine , New York, New York , USA.

ABSTRACT
This review describes eight 'great ideas' regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014. The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.

No MeSH data available.


Related in: MedlinePlus

Lipidomic assessments in human and murine lupus.
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Related In: Results  -  Collection

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LUPUS2015000087F2: Lipidomic assessments in human and murine lupus.

Mentions: GG focused on the growing acknowledgement that agnostic omics type screens have the potential for defining new pathways of pathogenesis in SLE. Proteomics, especially in defining urinary proteins in lupus nephritis, is an active ongoing field of research.3 New omics assessments are now possible due to the development of novel technologies. These include lipidomics and metabolomics at the cellular, organ and systemic level. Lipids play a key role in cell signalling and cell death. These lipid pathways are targetable and thus are potential therapeutic targets in SLE. Lipidomic assessments in human and murine lupus are shown in figure 2.4 The left panels show differences in lipid expression in patients with SLE compared with controls. The top panel A demonstrates that there is significant elevation of lactosyl ceramides in the urine of patients with lupus nephritis compared with urine from patients with lupus without renal disease and controls. (Panel B demonstrates that serum levels of this same ceramide, in contrast to marked differences in urinary levels, are similar in patients with or without nephritis, suggesting that the urinary levels are representative of renal production of the ceramide.) The bottom panel demonstrates staining for lactosyl ceramide in the kidney of a control, one patient with Class III lupus nephritis and one with Class IV lupus nephritis. Thus, one can demonstrate local expression of this lactosyl ceramide in the glomerulus of patients with active lupus nephritis.


A highlight from the LUPUS 2014 meeting: eight great ideas.

Buyon JP, Cohen P, Merrill JT, Gilkeson G, Kaplan M, James J, McCune WJ, Bernatsky S, Elkon K - Lupus Sci Med (2015)

Lipidomic assessments in human and murine lupus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493165&req=5

LUPUS2015000087F2: Lipidomic assessments in human and murine lupus.
Mentions: GG focused on the growing acknowledgement that agnostic omics type screens have the potential for defining new pathways of pathogenesis in SLE. Proteomics, especially in defining urinary proteins in lupus nephritis, is an active ongoing field of research.3 New omics assessments are now possible due to the development of novel technologies. These include lipidomics and metabolomics at the cellular, organ and systemic level. Lipids play a key role in cell signalling and cell death. These lipid pathways are targetable and thus are potential therapeutic targets in SLE. Lipidomic assessments in human and murine lupus are shown in figure 2.4 The left panels show differences in lipid expression in patients with SLE compared with controls. The top panel A demonstrates that there is significant elevation of lactosyl ceramides in the urine of patients with lupus nephritis compared with urine from patients with lupus without renal disease and controls. (Panel B demonstrates that serum levels of this same ceramide, in contrast to marked differences in urinary levels, are similar in patients with or without nephritis, suggesting that the urinary levels are representative of renal production of the ceramide.) The bottom panel demonstrates staining for lactosyl ceramide in the kidney of a control, one patient with Class III lupus nephritis and one with Class IV lupus nephritis. Thus, one can demonstrate local expression of this lactosyl ceramide in the glomerulus of patients with active lupus nephritis.

Bottom Line: This review describes eight 'great ideas' regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014.The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatology, Department of Medicine , NYU School of Medicine , New York, New York , USA.

ABSTRACT
This review describes eight 'great ideas' regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014. The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.

No MeSH data available.


Related in: MedlinePlus