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The Screening Performance of Serum 1,3-Beta-D-Glucan in Patients with Invasive Fungal Diseases: A Meta-Analysis of Prospective Cohort Studies.

Hou TY, Wang SH, Liang SX, Jiang WX, Luo DD, Huang DH - PLoS ONE (2015)

Bottom Line: A total of 1068 patients in 11 studies were analyzed.Deeks' funnel plot asymmetry test suggested a low likelihood of publication bias for the included studies (p = 0.055).The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver operating characteristic curve, with 95% confidence intervals, were 0.75(0.63,0.84), 0.87(0.81,0.92), 5.85(3.96,8.63), 0.30(0.20,0.45), 19.53(11.16,34.18), and 0.89(0.86,0.91), respectively.

View Article: PubMed Central - PubMed

Affiliation: Medical Department of HAI Control, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong province, 510080, China.

ABSTRACT
The serum 1,3-beta-D-glucan (BG) assay aids in the early diagnosis of invasive fungal diseases (IFDs) and has been approved for their diagnosis. However, reports on the screening performance of BG are scarce. We performed a meta-analysis of data extracted from only prospective cohort studies to evaluate the screening performance of the BG assay in the diagnosis of IFDs. We specifically searched 4 databases (the PubMed, Web of Science, Elsevier, and Cochrane Collaboration databases) according to EORTC-MSG criteria. A total of 1068 patients in 11 studies were analyzed. Deeks' funnel plot asymmetry test suggested a low likelihood of publication bias for the included studies (p = 0.055). The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver operating characteristic curve, with 95% confidence intervals, were 0.75(0.63,0.84), 0.87(0.81,0.92), 5.85(3.96,8.63), 0.30(0.20,0.45), 19.53(11.16,34.18), and 0.89(0.86,0.91), respectively. The findings of this meta-analysis suggest that the BG assay is a useful screening tool with high sensitivity and specificity for discriminating between patients with and without IFDs. In clinical practice, BG assay results should be evaluated together with clinical and microbiological findings.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the pooled sensitivity and specificity of the BG assays for the diagnosis of IFDs.
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pone.0131602.g003: Forest plot of the pooled sensitivity and specificity of the BG assays for the diagnosis of IFDs.

Mentions: The pooled sensitivity, specificity, PLR, DOR, and AUC, with 95% CIs, are summarized in Table 3 and Fig 3. A similar subgroup analysis was performed (see Table 3). Relatively high inter-study heterogeneity was noted in 11 studies, and the I2 index was74.35% (95% CI: 59.87,98.33%). The SROC curves are displayed in Fig 4. The AUC value was 0.89 (95% CI: 0.86–0.91). Publication bias was evaluated using Deeks’ funnel plot asymmetry test, as shown in Fig 5.


The Screening Performance of Serum 1,3-Beta-D-Glucan in Patients with Invasive Fungal Diseases: A Meta-Analysis of Prospective Cohort Studies.

Hou TY, Wang SH, Liang SX, Jiang WX, Luo DD, Huang DH - PLoS ONE (2015)

Forest plot of the pooled sensitivity and specificity of the BG assays for the diagnosis of IFDs.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493111&req=5

pone.0131602.g003: Forest plot of the pooled sensitivity and specificity of the BG assays for the diagnosis of IFDs.
Mentions: The pooled sensitivity, specificity, PLR, DOR, and AUC, with 95% CIs, are summarized in Table 3 and Fig 3. A similar subgroup analysis was performed (see Table 3). Relatively high inter-study heterogeneity was noted in 11 studies, and the I2 index was74.35% (95% CI: 59.87,98.33%). The SROC curves are displayed in Fig 4. The AUC value was 0.89 (95% CI: 0.86–0.91). Publication bias was evaluated using Deeks’ funnel plot asymmetry test, as shown in Fig 5.

Bottom Line: A total of 1068 patients in 11 studies were analyzed.Deeks' funnel plot asymmetry test suggested a low likelihood of publication bias for the included studies (p = 0.055).The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver operating characteristic curve, with 95% confidence intervals, were 0.75(0.63,0.84), 0.87(0.81,0.92), 5.85(3.96,8.63), 0.30(0.20,0.45), 19.53(11.16,34.18), and 0.89(0.86,0.91), respectively.

View Article: PubMed Central - PubMed

Affiliation: Medical Department of HAI Control, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong province, 510080, China.

ABSTRACT
The serum 1,3-beta-D-glucan (BG) assay aids in the early diagnosis of invasive fungal diseases (IFDs) and has been approved for their diagnosis. However, reports on the screening performance of BG are scarce. We performed a meta-analysis of data extracted from only prospective cohort studies to evaluate the screening performance of the BG assay in the diagnosis of IFDs. We specifically searched 4 databases (the PubMed, Web of Science, Elsevier, and Cochrane Collaboration databases) according to EORTC-MSG criteria. A total of 1068 patients in 11 studies were analyzed. Deeks' funnel plot asymmetry test suggested a low likelihood of publication bias for the included studies (p = 0.055). The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver operating characteristic curve, with 95% confidence intervals, were 0.75(0.63,0.84), 0.87(0.81,0.92), 5.85(3.96,8.63), 0.30(0.20,0.45), 19.53(11.16,34.18), and 0.89(0.86,0.91), respectively. The findings of this meta-analysis suggest that the BG assay is a useful screening tool with high sensitivity and specificity for discriminating between patients with and without IFDs. In clinical practice, BG assay results should be evaluated together with clinical and microbiological findings.

No MeSH data available.


Related in: MedlinePlus