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The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Depression: A Meta-Analysis.

Fang L, Zhou C, Bai S, Huang C, Pan J, Wang L, Wang X, Mao Q, Sun L, Xie P - PLoS ONE (2015)

Bottom Line: TheG-protein β3 gene (GNβ3) has been implicated in psychiatric illness through its effects upon intracellular transduction of several neurotransmitter receptors.Pooled ORs were constructed for allele contrast (C versus T), homozygote (CC versus TT) model, heterozygote (CC versus CT) model, dominant model (CC + CT versus TT), and recessive (CC versus TT+CT) model.After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, China.

ABSTRACT

Background: TheG-protein β3 gene (GNβ3) has been implicated in psychiatric illness through its effects upon intracellular transduction of several neurotransmitter receptors. Multiple studies have investigated the relationship of the C825T polymorphism of the GNβ3 gene (GNβ3 C825T) to depression and antidepressant response. However, the relationship between GNβ3 C825T and depression remains inconsistent. Therefore, here we performed a meta-analysis to investigate the role of GNβ3 C825Tin depression risk.

Methods: Published case-control studies examining the association between GNβ3 C825T and depression were systematically searched for through several electronic databases (PubMed, Scopus, Science Direct, Springer, Embase, psyINFO, and CNKI). The association between GNβ3 C825T and depression risk were assessed by odd ratios (ORs) and their 95% confidence intervals (CIs) for each study. Pooled ORs were constructed for allele contrast (C versus T), homozygote (CC versus TT) model, heterozygote (CC versus CT) model, dominant model (CC + CT versus TT), and recessive (CC versus TT+CT) model. In order to evaluate possible biases, a sensitivity analysis was conducted by sequential deletion of individual studies in an attempt to assess the contribution of each individual dataset to the pooled OR.

Results: Nine studies, including 1055 depressed patients and 1325 healthy controls, were included. A significant association between GNβ3 C825Tand depression was found to exist, suggesting that the T-allele of GNβ3 C825Tcan increase susceptibility to depression. After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation.

Conclusions: This is the first meta-analysis to reveal a relationship between GNβ3 C825T and depression. Asian T-allele carriers of GNβ3 C825T appear to be more susceptible to depression.

No MeSH data available.


Related in: MedlinePlus

Further Meta-Analyses for the Association between the GNβ3 C825T Polymorphism and Depression.Overall and subgroup forest plots showing the summary effect sizes and heterogeneity findings for (A) TT homozygosity versus CC homozygosity, (B) the heterozygote model (CC versus CT), and (C) the dominant model (CC + CT versus TT).
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pone.0132274.g003: Further Meta-Analyses for the Association between the GNβ3 C825T Polymorphism and Depression.Overall and subgroup forest plots showing the summary effect sizes and heterogeneity findings for (A) TT homozygosity versus CC homozygosity, (B) the heterozygote model (CC versus CT), and (C) the dominant model (CC + CT versus TT).

Mentions: The nine case-control studies, consisting of 1055 depressed cases and 1325 controls, were pooled together to assess the association between depression and GNβ3 C825T. On the basis of the random effects model, the pooled OR for the T-allele of GNβ3 C825T showed a significant correlation with depression risk under the allele model (C-allele versus T-allele: OR = 1.39, 95% CI = 1.13–1.72, Z = 3.10, P = 0.002; Fig 2). When we calculated the pooled OR for TT homozygosity relative to CC homozygosity, the OR increased to 1.84 (95% CI = 1.20–2.83, Z = 2.81, P = 0.005; Fig 3). Significant associations between the T-allele of GNβ3 C825T and depression risk were also observed under the dominant model (CC + CT versus TT: OR = 1.54, 95% CI = 1.08–2.18, P = 0.02), the recessive model (CC versus CT+TT: OR = 1.53, 95% CI = 1.15–2.04, P = 0.02), and the heterozygote model (CC versus CT: OR = 1.32, 95% CI = 1.08–1.62, P = 0.03; Figs 2 and 3).


The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Depression: A Meta-Analysis.

Fang L, Zhou C, Bai S, Huang C, Pan J, Wang L, Wang X, Mao Q, Sun L, Xie P - PLoS ONE (2015)

Further Meta-Analyses for the Association between the GNβ3 C825T Polymorphism and Depression.Overall and subgroup forest plots showing the summary effect sizes and heterogeneity findings for (A) TT homozygosity versus CC homozygosity, (B) the heterozygote model (CC versus CT), and (C) the dominant model (CC + CT versus TT).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493085&req=5

pone.0132274.g003: Further Meta-Analyses for the Association between the GNβ3 C825T Polymorphism and Depression.Overall and subgroup forest plots showing the summary effect sizes and heterogeneity findings for (A) TT homozygosity versus CC homozygosity, (B) the heterozygote model (CC versus CT), and (C) the dominant model (CC + CT versus TT).
Mentions: The nine case-control studies, consisting of 1055 depressed cases and 1325 controls, were pooled together to assess the association between depression and GNβ3 C825T. On the basis of the random effects model, the pooled OR for the T-allele of GNβ3 C825T showed a significant correlation with depression risk under the allele model (C-allele versus T-allele: OR = 1.39, 95% CI = 1.13–1.72, Z = 3.10, P = 0.002; Fig 2). When we calculated the pooled OR for TT homozygosity relative to CC homozygosity, the OR increased to 1.84 (95% CI = 1.20–2.83, Z = 2.81, P = 0.005; Fig 3). Significant associations between the T-allele of GNβ3 C825T and depression risk were also observed under the dominant model (CC + CT versus TT: OR = 1.54, 95% CI = 1.08–2.18, P = 0.02), the recessive model (CC versus CT+TT: OR = 1.53, 95% CI = 1.15–2.04, P = 0.02), and the heterozygote model (CC versus CT: OR = 1.32, 95% CI = 1.08–1.62, P = 0.03; Figs 2 and 3).

Bottom Line: TheG-protein β3 gene (GNβ3) has been implicated in psychiatric illness through its effects upon intracellular transduction of several neurotransmitter receptors.Pooled ORs were constructed for allele contrast (C versus T), homozygote (CC versus TT) model, heterozygote (CC versus CT) model, dominant model (CC + CT versus TT), and recessive (CC versus TT+CT) model.After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, China.

ABSTRACT

Background: TheG-protein β3 gene (GNβ3) has been implicated in psychiatric illness through its effects upon intracellular transduction of several neurotransmitter receptors. Multiple studies have investigated the relationship of the C825T polymorphism of the GNβ3 gene (GNβ3 C825T) to depression and antidepressant response. However, the relationship between GNβ3 C825T and depression remains inconsistent. Therefore, here we performed a meta-analysis to investigate the role of GNβ3 C825Tin depression risk.

Methods: Published case-control studies examining the association between GNβ3 C825T and depression were systematically searched for through several electronic databases (PubMed, Scopus, Science Direct, Springer, Embase, psyINFO, and CNKI). The association between GNβ3 C825T and depression risk were assessed by odd ratios (ORs) and their 95% confidence intervals (CIs) for each study. Pooled ORs were constructed for allele contrast (C versus T), homozygote (CC versus TT) model, heterozygote (CC versus CT) model, dominant model (CC + CT versus TT), and recessive (CC versus TT+CT) model. In order to evaluate possible biases, a sensitivity analysis was conducted by sequential deletion of individual studies in an attempt to assess the contribution of each individual dataset to the pooled OR.

Results: Nine studies, including 1055 depressed patients and 1325 healthy controls, were included. A significant association between GNβ3 C825Tand depression was found to exist, suggesting that the T-allele of GNβ3 C825Tcan increase susceptibility to depression. After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation.

Conclusions: This is the first meta-analysis to reveal a relationship between GNβ3 C825T and depression. Asian T-allele carriers of GNβ3 C825T appear to be more susceptible to depression.

No MeSH data available.


Related in: MedlinePlus