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The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Depression: A Meta-Analysis.

Fang L, Zhou C, Bai S, Huang C, Pan J, Wang L, Wang X, Mao Q, Sun L, Xie P - PLoS ONE (2015)

Bottom Line: TheG-protein β3 gene (GNβ3) has been implicated in psychiatric illness through its effects upon intracellular transduction of several neurotransmitter receptors.Pooled ORs were constructed for allele contrast (C versus T), homozygote (CC versus TT) model, heterozygote (CC versus CT) model, dominant model (CC + CT versus TT), and recessive (CC versus TT+CT) model.After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, China.

ABSTRACT

Background: TheG-protein β3 gene (GNβ3) has been implicated in psychiatric illness through its effects upon intracellular transduction of several neurotransmitter receptors. Multiple studies have investigated the relationship of the C825T polymorphism of the GNβ3 gene (GNβ3 C825T) to depression and antidepressant response. However, the relationship between GNβ3 C825T and depression remains inconsistent. Therefore, here we performed a meta-analysis to investigate the role of GNβ3 C825Tin depression risk.

Methods: Published case-control studies examining the association between GNβ3 C825T and depression were systematically searched for through several electronic databases (PubMed, Scopus, Science Direct, Springer, Embase, psyINFO, and CNKI). The association between GNβ3 C825T and depression risk were assessed by odd ratios (ORs) and their 95% confidence intervals (CIs) for each study. Pooled ORs were constructed for allele contrast (C versus T), homozygote (CC versus TT) model, heterozygote (CC versus CT) model, dominant model (CC + CT versus TT), and recessive (CC versus TT+CT) model. In order to evaluate possible biases, a sensitivity analysis was conducted by sequential deletion of individual studies in an attempt to assess the contribution of each individual dataset to the pooled OR.

Results: Nine studies, including 1055 depressed patients and 1325 healthy controls, were included. A significant association between GNβ3 C825Tand depression was found to exist, suggesting that the T-allele of GNβ3 C825Tcan increase susceptibility to depression. After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation.

Conclusions: This is the first meta-analysis to reveal a relationship between GNβ3 C825T and depression. Asian T-allele carriers of GNβ3 C825T appear to be more susceptible to depression.

No MeSH data available.


Related in: MedlinePlus

Flowchart of Study Selection.
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pone.0132274.g001: Flowchart of Study Selection.

Mentions: The study selection procedure is shown in Fig 1. The literature search identified 230 potentially relevant records. After screening titles and abstracts, 29 full-text articles were reviewed, of which 20 were excluded for the following reasons: (i) four studies were systematic reviews or meta-analyses on G-protein function [6,11,18,19]; (ii) seven studies assessed SNP effects in other psychiatric disorders [20–26]; (iii) three studies did not use a case-control design [27–29]; (iv) three studies did not assess GNβ3 C825T but measured G-protein expression [5,30,31]; and (v) three studies assessed GNβ3 C825T and the antidepressant response [16,32,33]. There were no previously published GWAS concerning GNβ3 C825T in depression, so no GWAS was included in this meta-analysis.


The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Depression: A Meta-Analysis.

Fang L, Zhou C, Bai S, Huang C, Pan J, Wang L, Wang X, Mao Q, Sun L, Xie P - PLoS ONE (2015)

Flowchart of Study Selection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493085&req=5

pone.0132274.g001: Flowchart of Study Selection.
Mentions: The study selection procedure is shown in Fig 1. The literature search identified 230 potentially relevant records. After screening titles and abstracts, 29 full-text articles were reviewed, of which 20 were excluded for the following reasons: (i) four studies were systematic reviews or meta-analyses on G-protein function [6,11,18,19]; (ii) seven studies assessed SNP effects in other psychiatric disorders [20–26]; (iii) three studies did not use a case-control design [27–29]; (iv) three studies did not assess GNβ3 C825T but measured G-protein expression [5,30,31]; and (v) three studies assessed GNβ3 C825T and the antidepressant response [16,32,33]. There were no previously published GWAS concerning GNβ3 C825T in depression, so no GWAS was included in this meta-analysis.

Bottom Line: TheG-protein β3 gene (GNβ3) has been implicated in psychiatric illness through its effects upon intracellular transduction of several neurotransmitter receptors.Pooled ORs were constructed for allele contrast (C versus T), homozygote (CC versus TT) model, heterozygote (CC versus CT) model, dominant model (CC + CT versus TT), and recessive (CC versus TT+CT) model.After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, China.

ABSTRACT

Background: TheG-protein β3 gene (GNβ3) has been implicated in psychiatric illness through its effects upon intracellular transduction of several neurotransmitter receptors. Multiple studies have investigated the relationship of the C825T polymorphism of the GNβ3 gene (GNβ3 C825T) to depression and antidepressant response. However, the relationship between GNβ3 C825T and depression remains inconsistent. Therefore, here we performed a meta-analysis to investigate the role of GNβ3 C825Tin depression risk.

Methods: Published case-control studies examining the association between GNβ3 C825T and depression were systematically searched for through several electronic databases (PubMed, Scopus, Science Direct, Springer, Embase, psyINFO, and CNKI). The association between GNβ3 C825T and depression risk were assessed by odd ratios (ORs) and their 95% confidence intervals (CIs) for each study. Pooled ORs were constructed for allele contrast (C versus T), homozygote (CC versus TT) model, heterozygote (CC versus CT) model, dominant model (CC + CT versus TT), and recessive (CC versus TT+CT) model. In order to evaluate possible biases, a sensitivity analysis was conducted by sequential deletion of individual studies in an attempt to assess the contribution of each individual dataset to the pooled OR.

Results: Nine studies, including 1055 depressed patients and 1325 healthy controls, were included. A significant association between GNβ3 C825Tand depression was found to exist, suggesting that the T-allele of GNβ3 C825Tcan increase susceptibility to depression. After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation.

Conclusions: This is the first meta-analysis to reveal a relationship between GNβ3 C825T and depression. Asian T-allele carriers of GNβ3 C825T appear to be more susceptible to depression.

No MeSH data available.


Related in: MedlinePlus