Incidence and Geographic Distribution of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa.
Bottom Line:
South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation.This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012.XDR-TB cases are widely distributed geographically, with the majority of districts experiencing a rise in incidence.
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Affiliation: Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
ABSTRACT
South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012. XDR-TB cases are widely distributed geographically, with the majority of districts experiencing a rise in incidence. No MeSH data available. Related in: MedlinePlus |
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pone.0132076.g001: Change in incidence of XDR-TB in KwaZulu-Natal province, South Africa, 2007 to 2010–12.Panel A shows the XDR-TB incidence (per 100,000 population) in each district in 2007. Panel B shows the average XDR-TB incidence by district in 2010–2012. The size of the circles is proportional to the incidence rate. The colors in panel B represents the change in incidence compared to 2007 data: red, increase; green, decrease. Mentions: The average number of XDR-TB cases in the province each year increased from 270 to 358 and the overall incidenc e increased by 13%, compared to 2007 (Table 1). XDR-TB incidence increased in 8 of 11 districts, with the magnitude of increases ranging from 9% to 857% (Fig 1). In Umzinyathi and uMgungundlovu, although the incidence declined over this time period, it remained among the highest in the province at 12.1 and 3.4 XDR-TB cases/100,000, respectively. The burden of XDR-TB cases remains concentrated in Umzinyathi eThekwini, and uMgungundlovu; eThekwini and uMgungundlovu are home to Durban and Pietermaritzburg, the two largest cities in KwaZulu-Natal that account for nearly half of the provincial population. |
View Article: PubMed Central - PubMed
Affiliation: Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
No MeSH data available.