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Changes in Serum Levels of Myokines and Wnt-Antagonists after an Ultramarathon Race.

Kerschan-Schindl K, Thalmann MM, Weiss E, Tsironi M, Föger-Samwald U, Meinhart J, Skenderi K, Pietschmann P - PLoS ONE (2015)

Bottom Line: Serum levels of myostatin were significantly higher after the race.Sclerostin levels did not significantly differ before and after the race, whereas dickkopf-1 levels were significantly decreased.Serum cathepsin K levels did not change.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, Medical University of Vienna, Vienna, Austria.

ABSTRACT

Background: Regular physical activities have a positive effect on the muscular skeletal system but overstrenuous exercise may be different. Transiently suppressed bone formation and increased bone resorption after participation in a 246-km ultradistance race has been demonstrated.

Purpose: The aim of this study was to analyze effects of the Spartathlon race on novel musculoskeletal markers.

Methods: Venous blood samples were obtained before and immediately after the race from 19 participants of the Spartathlon. From 9 runners who were available 3 days after the start blood was drawn for a third time. Serum levels of myostatin, an inhibitor of myogenic differentiation, and its opponent follistatin as well as sclerostin and dickkopf-1, both of them inhibitors of the wnt signaling pathway, and markers of bone turnover were determined.

Results: Serum levels of myostatin were significantly higher after the race. Serum follistatin only showed a transient increase. Sclerostin levels did not significantly differ before and after the race, whereas dickkopf-1 levels were significantly decreased. At follow-up a decrement of sclerostin and dickkopf-1 levels was seen. Serum cathepsin K levels did not change.

Conclusion: The increase of serum levels of myostatin appears to reflect muscle catabolic processes induced by overstrenuous exercise. After the short-term uncoupling of bone turnover participation in an ultradistance race seems to initiate a long-term positive effect on bone indicated by the low-level inhibition of the Wnt/β-catenin signaling pathway.

No MeSH data available.


Related in: MedlinePlus

Serum levels of myostatin (A), follistatin (B), sclerostin (C), and Dkk-1 (D) before the run (Athens), immediately after the run (Sparta), and three days after the start of the race (post).
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pone.0132478.g001: Serum levels of myostatin (A), follistatin (B), sclerostin (C), and Dkk-1 (D) before the run (Athens), immediately after the run (Sparta), and three days after the start of the race (post).

Mentions: Similar to the whole group of participants, in the group of nine runners with three blood samples taken, serum levels of myostatin and follistatin were higher when reaching Sparta compared to before the race (Fig 1). During the follow-up, myostatin levels remained more or less unchanged. Serum follistatin decreased again; it did not show a significant change 3 days after the start of the race compared to the time point of the first biochemical analysis. Boxplots of serum sclerostin and Dkk-1 for all measurements of the nine participants are also given in Fig 1. In contrast to the whole group of study participants, in the group of nine runners with three blood samples taken, the serum levels of Dkk-1 from pre- to post race did not reach statistical significance. Nevertheless, Dkk1 values three days after the race were significantly lower than at the other two time points. Both inhibitors of the Wnt signaling pathway significantly decreased from immediately after the race to the last measurement.


Changes in Serum Levels of Myokines and Wnt-Antagonists after an Ultramarathon Race.

Kerschan-Schindl K, Thalmann MM, Weiss E, Tsironi M, Föger-Samwald U, Meinhart J, Skenderi K, Pietschmann P - PLoS ONE (2015)

Serum levels of myostatin (A), follistatin (B), sclerostin (C), and Dkk-1 (D) before the run (Athens), immediately after the run (Sparta), and three days after the start of the race (post).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4493015&req=5

pone.0132478.g001: Serum levels of myostatin (A), follistatin (B), sclerostin (C), and Dkk-1 (D) before the run (Athens), immediately after the run (Sparta), and three days after the start of the race (post).
Mentions: Similar to the whole group of participants, in the group of nine runners with three blood samples taken, serum levels of myostatin and follistatin were higher when reaching Sparta compared to before the race (Fig 1). During the follow-up, myostatin levels remained more or less unchanged. Serum follistatin decreased again; it did not show a significant change 3 days after the start of the race compared to the time point of the first biochemical analysis. Boxplots of serum sclerostin and Dkk-1 for all measurements of the nine participants are also given in Fig 1. In contrast to the whole group of study participants, in the group of nine runners with three blood samples taken, the serum levels of Dkk-1 from pre- to post race did not reach statistical significance. Nevertheless, Dkk1 values three days after the race were significantly lower than at the other two time points. Both inhibitors of the Wnt signaling pathway significantly decreased from immediately after the race to the last measurement.

Bottom Line: Serum levels of myostatin were significantly higher after the race.Sclerostin levels did not significantly differ before and after the race, whereas dickkopf-1 levels were significantly decreased.Serum cathepsin K levels did not change.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, Medical University of Vienna, Vienna, Austria.

ABSTRACT

Background: Regular physical activities have a positive effect on the muscular skeletal system but overstrenuous exercise may be different. Transiently suppressed bone formation and increased bone resorption after participation in a 246-km ultradistance race has been demonstrated.

Purpose: The aim of this study was to analyze effects of the Spartathlon race on novel musculoskeletal markers.

Methods: Venous blood samples were obtained before and immediately after the race from 19 participants of the Spartathlon. From 9 runners who were available 3 days after the start blood was drawn for a third time. Serum levels of myostatin, an inhibitor of myogenic differentiation, and its opponent follistatin as well as sclerostin and dickkopf-1, both of them inhibitors of the wnt signaling pathway, and markers of bone turnover were determined.

Results: Serum levels of myostatin were significantly higher after the race. Serum follistatin only showed a transient increase. Sclerostin levels did not significantly differ before and after the race, whereas dickkopf-1 levels were significantly decreased. At follow-up a decrement of sclerostin and dickkopf-1 levels was seen. Serum cathepsin K levels did not change.

Conclusion: The increase of serum levels of myostatin appears to reflect muscle catabolic processes induced by overstrenuous exercise. After the short-term uncoupling of bone turnover participation in an ultradistance race seems to initiate a long-term positive effect on bone indicated by the low-level inhibition of the Wnt/β-catenin signaling pathway.

No MeSH data available.


Related in: MedlinePlus