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Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches.

Al-Amiery AA, Al-Majedy YK, Kadhum AA, Mohamad AB - PLoS ONE (2015)

Bottom Line: The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS).In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C.Our results reveal that these compounds exhibit excellent radical scavenging activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Process Engineering, University Kebangsaan Malaysia (UKM), Bangi, Selangor, 43000, Malaysia; Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq.

ABSTRACT
New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.

No MeSH data available.


Suggested mechanism for compound 8 as an antioxidant.
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pone.0132175.g004: Suggested mechanism for compound 8 as an antioxidant.

Mentions: The postulated antioxidant mechanism for synthesized coumarin 8, as shown in Fig 4, relies on the hydroxyl hydrogen atom (bold), which is under the influence of resonance and inductive effects. The resonance effect of the oxygen hydrogen facilitates the release of hydrogen, while the inductive effect pushes the electrons toward the oxygen-free radical, resulting in stability of the molecule [28]. Note that coumarin 8 has a higher scavenging activity because of the stability of the free radical intermediates of this coumarin [29].


Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches.

Al-Amiery AA, Al-Majedy YK, Kadhum AA, Mohamad AB - PLoS ONE (2015)

Suggested mechanism for compound 8 as an antioxidant.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492988&req=5

pone.0132175.g004: Suggested mechanism for compound 8 as an antioxidant.
Mentions: The postulated antioxidant mechanism for synthesized coumarin 8, as shown in Fig 4, relies on the hydroxyl hydrogen atom (bold), which is under the influence of resonance and inductive effects. The resonance effect of the oxygen hydrogen facilitates the release of hydrogen, while the inductive effect pushes the electrons toward the oxygen-free radical, resulting in stability of the molecule [28]. Note that coumarin 8 has a higher scavenging activity because of the stability of the free radical intermediates of this coumarin [29].

Bottom Line: The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS).In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C.Our results reveal that these compounds exhibit excellent radical scavenging activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Process Engineering, University Kebangsaan Malaysia (UKM), Bangi, Selangor, 43000, Malaysia; Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq.

ABSTRACT
New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.

No MeSH data available.