Limits...
Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches.

Al-Amiery AA, Al-Majedy YK, Kadhum AA, Mohamad AB - PLoS ONE (2015)

Bottom Line: The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS).In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C.Our results reveal that these compounds exhibit excellent radical scavenging activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Process Engineering, University Kebangsaan Malaysia (UKM), Bangi, Selangor, 43000, Malaysia; Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq.

ABSTRACT
New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.

No MeSH data available.


Percentage inhibition of hydrogen peroxide scavenging activity of synthesized compounds (1–8) in comparison to Vitamin C.n = 3. Error bars indicate standard deviation.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4492988&req=5

pone.0132175.g002: Percentage inhibition of hydrogen peroxide scavenging activity of synthesized compounds (1–8) in comparison to Vitamin C.n = 3. Error bars indicate standard deviation.

Mentions: The role of a cancer prevention agent is to remove free radicals. The most important mechanism to achieve this goal is the donation of hydrogen to free radicals to convert them to nonreactive species [24]. The donation of hydrogen would remove the odd electron that is responsible for radical reactivity [25]. Free radicals have been a subject of critical interest among researchers in the previous decade. The wide range of free radical effects in biological systems has garnered interest from many specialists. It has been demonstrated that free radicals assume an important role in the pathogenesis of specific diseases and aging [24,25]. Numerous synthetic cancer prevention agents have presented toxic and/or mutagenic effects; thus, naturally occurring antioxidants have been considered [26]. Synthesized coumarins 1–8 were screened for in vitro scavenging activity utilizing hydrogen peroxide. These tested coumarins showed high scavenging activity (Fig 2).


Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches.

Al-Amiery AA, Al-Majedy YK, Kadhum AA, Mohamad AB - PLoS ONE (2015)

Percentage inhibition of hydrogen peroxide scavenging activity of synthesized compounds (1–8) in comparison to Vitamin C.n = 3. Error bars indicate standard deviation.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492988&req=5

pone.0132175.g002: Percentage inhibition of hydrogen peroxide scavenging activity of synthesized compounds (1–8) in comparison to Vitamin C.n = 3. Error bars indicate standard deviation.
Mentions: The role of a cancer prevention agent is to remove free radicals. The most important mechanism to achieve this goal is the donation of hydrogen to free radicals to convert them to nonreactive species [24]. The donation of hydrogen would remove the odd electron that is responsible for radical reactivity [25]. Free radicals have been a subject of critical interest among researchers in the previous decade. The wide range of free radical effects in biological systems has garnered interest from many specialists. It has been demonstrated that free radicals assume an important role in the pathogenesis of specific diseases and aging [24,25]. Numerous synthetic cancer prevention agents have presented toxic and/or mutagenic effects; thus, naturally occurring antioxidants have been considered [26]. Synthesized coumarins 1–8 were screened for in vitro scavenging activity utilizing hydrogen peroxide. These tested coumarins showed high scavenging activity (Fig 2).

Bottom Line: The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS).In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C.Our results reveal that these compounds exhibit excellent radical scavenging activities.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Process Engineering, University Kebangsaan Malaysia (UKM), Bangi, Selangor, 43000, Malaysia; Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq.

ABSTRACT
New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.

No MeSH data available.