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Altered Resting-State Brain Activity and Connectivity in Depressed Parkinson's Disease.

Hu X, Song X, Li E, Liu J, Yuan Y, Liu W, Liu Y - PLoS ONE (2015)

Bottom Line: Compared with the NDPD and HC, the DPD group showed significantly increased ALFF in the left median cingulated cortex (MCC).Compared with the HC and NDPD group, the DPD patients showed stronger FC between the left MCC and some of the major nodes of the default mode network (DMN), including the post cingulated cortex/precuneus, medial prefrontal cortex, inferior frontal gyrus, and cerebellum.Moreover, higher local activities in the left MCC were associated with increased functional connections between the MCC and the nodes of DMN in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.

ABSTRACT
Depressive symptoms are common in Parkinson's disease (PD), but the neurophysiological mechanisms of depression in PD are poorly understood. The current study attempted to examine disrupted spontaneous local brain activities and functional connectivities that underlie the depression in PD. We recruited a total of 20 depressed PD patients (DPD), 40 non-depressed PD patients (NDPD) and 43 matched healthy controls (HC). All the subjects underwent neuropsychological tests and resting-state fMRI scanning. The between-group differences in the amplitude of low frequency fluctuations (ALFF) of BOLD signals were examined using post-hoc tests after the analysis of covariance. Compared with the NDPD and HC, the DPD group showed significantly increased ALFF in the left median cingulated cortex (MCC). The functional connectivity (FC) between left MCC and all the other voxels in the brain were then calculated. Compared with the HC and NDPD group, the DPD patients showed stronger FC between the left MCC and some of the major nodes of the default mode network (DMN), including the post cingulated cortex/precuneus, medial prefrontal cortex, inferior frontal gyrus, and cerebellum. Correlation analysis revealed that both the ALFF values in the left MCC and the FC between the left MCC and the nodes of DMN were significantly correlated with the Hamilton Depression Rating Scale score. Moreover, higher local activities in the left MCC were associated with increased functional connections between the MCC and the nodes of DMN in PD. These abnormal activities and connectivities of the limbic-cortical circuit may indicate impaired high-order cortical control or uncontrol of negative mood in DPD, which suggested a possible neural mechanism of the depression in PD.

No MeSH data available.


Related in: MedlinePlus

Statistical parametric map showing the significant differences in the MCC FC between three groups: DPD, NDPD and HC.The ANCOVA thresholds were set at a voxel-level p < 0.01, cluster size > 918 mm3 /34 voxels, corresponding to a corrected p < 0.05 as determined by AlphaSim correction. A two-sample post hoc t-test was performed between each pair of the three groups (DPD vs NDPD, DPD vs HC, NDPD vs HC)(voxel-level p < 0.01, cluster size > 162 mm3 /6 voxels, corresponding to a corrected p < 0.05 as determined by AlphaSim correction). Statistical parametric map showing the significant correlations between HAMD score and FC value in left MCC and other ROIs. Statistical parametric map also showing the significant correlations between ALFF value of left MCC and FC value in left MCC and other ROIs.
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pone.0131133.g002: Statistical parametric map showing the significant differences in the MCC FC between three groups: DPD, NDPD and HC.The ANCOVA thresholds were set at a voxel-level p < 0.01, cluster size > 918 mm3 /34 voxels, corresponding to a corrected p < 0.05 as determined by AlphaSim correction. A two-sample post hoc t-test was performed between each pair of the three groups (DPD vs NDPD, DPD vs HC, NDPD vs HC)(voxel-level p < 0.01, cluster size > 162 mm3 /6 voxels, corresponding to a corrected p < 0.05 as determined by AlphaSim correction). Statistical parametric map showing the significant correlations between HAMD score and FC value in left MCC and other ROIs. Statistical parametric map also showing the significant correlations between ALFF value of left MCC and FC value in left MCC and other ROIs.

Mentions: Two-sample post hoc t-tests were then performed to determine significant differences of left MCC FC between DPD and NDPD. Compared with the NDPD patients, DPD patients exhibited increased left MCC FC with the left precuneus and left MPFC, and decreased left MCC FC with the left IFG and left cerebellum. Compared with the HC, DPD group both showed increased left MCC FC with the left MPFC, right calcarine gyrus, left cuneus gyrus, left precuneus, bilateral paracentral lobule, and bilateral precentral gyrus, and decreased left MCC FC with left cerebellum, and left IFG. Compared with the NDPD patients and HC, DPD patients exhibited increased left MCC FC with the left precuneus and left MPFC, and decreased left MCC FC with the left IFG and left cerebellum. Compared with the HC, NDPD group showed increased left MCC FC with the right lingual, left precuneus, right calcarine gyrus, left cuneus gyrus, bilateral paracentral lobule, and bilateral precentral gyrus, and decreased left MCC with the left cerebellum and left IFG. (Fig 2 and Table 3).


Altered Resting-State Brain Activity and Connectivity in Depressed Parkinson's Disease.

Hu X, Song X, Li E, Liu J, Yuan Y, Liu W, Liu Y - PLoS ONE (2015)

Statistical parametric map showing the significant differences in the MCC FC between three groups: DPD, NDPD and HC.The ANCOVA thresholds were set at a voxel-level p < 0.01, cluster size > 918 mm3 /34 voxels, corresponding to a corrected p < 0.05 as determined by AlphaSim correction. A two-sample post hoc t-test was performed between each pair of the three groups (DPD vs NDPD, DPD vs HC, NDPD vs HC)(voxel-level p < 0.01, cluster size > 162 mm3 /6 voxels, corresponding to a corrected p < 0.05 as determined by AlphaSim correction). Statistical parametric map showing the significant correlations between HAMD score and FC value in left MCC and other ROIs. Statistical parametric map also showing the significant correlations between ALFF value of left MCC and FC value in left MCC and other ROIs.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492789&req=5

pone.0131133.g002: Statistical parametric map showing the significant differences in the MCC FC between three groups: DPD, NDPD and HC.The ANCOVA thresholds were set at a voxel-level p < 0.01, cluster size > 918 mm3 /34 voxels, corresponding to a corrected p < 0.05 as determined by AlphaSim correction. A two-sample post hoc t-test was performed between each pair of the three groups (DPD vs NDPD, DPD vs HC, NDPD vs HC)(voxel-level p < 0.01, cluster size > 162 mm3 /6 voxels, corresponding to a corrected p < 0.05 as determined by AlphaSim correction). Statistical parametric map showing the significant correlations between HAMD score and FC value in left MCC and other ROIs. Statistical parametric map also showing the significant correlations between ALFF value of left MCC and FC value in left MCC and other ROIs.
Mentions: Two-sample post hoc t-tests were then performed to determine significant differences of left MCC FC between DPD and NDPD. Compared with the NDPD patients, DPD patients exhibited increased left MCC FC with the left precuneus and left MPFC, and decreased left MCC FC with the left IFG and left cerebellum. Compared with the HC, DPD group both showed increased left MCC FC with the left MPFC, right calcarine gyrus, left cuneus gyrus, left precuneus, bilateral paracentral lobule, and bilateral precentral gyrus, and decreased left MCC FC with left cerebellum, and left IFG. Compared with the NDPD patients and HC, DPD patients exhibited increased left MCC FC with the left precuneus and left MPFC, and decreased left MCC FC with the left IFG and left cerebellum. Compared with the HC, NDPD group showed increased left MCC FC with the right lingual, left precuneus, right calcarine gyrus, left cuneus gyrus, bilateral paracentral lobule, and bilateral precentral gyrus, and decreased left MCC with the left cerebellum and left IFG. (Fig 2 and Table 3).

Bottom Line: Compared with the NDPD and HC, the DPD group showed significantly increased ALFF in the left median cingulated cortex (MCC).Compared with the HC and NDPD group, the DPD patients showed stronger FC between the left MCC and some of the major nodes of the default mode network (DMN), including the post cingulated cortex/precuneus, medial prefrontal cortex, inferior frontal gyrus, and cerebellum.Moreover, higher local activities in the left MCC were associated with increased functional connections between the MCC and the nodes of DMN in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.

ABSTRACT
Depressive symptoms are common in Parkinson's disease (PD), but the neurophysiological mechanisms of depression in PD are poorly understood. The current study attempted to examine disrupted spontaneous local brain activities and functional connectivities that underlie the depression in PD. We recruited a total of 20 depressed PD patients (DPD), 40 non-depressed PD patients (NDPD) and 43 matched healthy controls (HC). All the subjects underwent neuropsychological tests and resting-state fMRI scanning. The between-group differences in the amplitude of low frequency fluctuations (ALFF) of BOLD signals were examined using post-hoc tests after the analysis of covariance. Compared with the NDPD and HC, the DPD group showed significantly increased ALFF in the left median cingulated cortex (MCC). The functional connectivity (FC) between left MCC and all the other voxels in the brain were then calculated. Compared with the HC and NDPD group, the DPD patients showed stronger FC between the left MCC and some of the major nodes of the default mode network (DMN), including the post cingulated cortex/precuneus, medial prefrontal cortex, inferior frontal gyrus, and cerebellum. Correlation analysis revealed that both the ALFF values in the left MCC and the FC between the left MCC and the nodes of DMN were significantly correlated with the Hamilton Depression Rating Scale score. Moreover, higher local activities in the left MCC were associated with increased functional connections between the MCC and the nodes of DMN in PD. These abnormal activities and connectivities of the limbic-cortical circuit may indicate impaired high-order cortical control or uncontrol of negative mood in DPD, which suggested a possible neural mechanism of the depression in PD.

No MeSH data available.


Related in: MedlinePlus