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Impact of the Preoperative Controlling Nutritional Status (CONUT) Score on the Survival after Curative Surgery for Colorectal Cancer.

Iseki Y, Shibutani M, Maeda K, Nagahara H, Ohtani H, Sugano K, Ikeya T, Muguruma K, Tanaka H, Toyokawa T, Sakurai K, Hirakawa K - PLoS ONE (2015)

Bottom Line: The five-year cancer-specific survival (CSS) rate was significantly higher at 92.7% in the low CONUT group, compared to a rate of 81.0% in the high CONUT group (p=0.0016).The five-year CSS was 71.2% in the low PNI group and 92.3% in the high PNI group, which showed a significant difference (p=0.0155).This study suggested that the CONUT score is a strong independent predictor of the survival among CRC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.

ABSTRACT

Background: Recently, the preoperative immune-nutritional status has been reported to correlate with the survival rate in patients with colorectal cancer (CRC). However, there have been no reports on the relationship between the controlling nutritional status (CONUT) score and the clinical outcome after curative surgery for CRC. We herein evaluated the prognostic significance of the CONUT score in patients with CRC, and then compared the accuracy of the CONUT score and the prognostic nutritional index (PNI) as a predictor of survival.

Methods: We retrospectively reviewed a database of 204 patients who underwent curative surgery for Stage II/III CRC. Patients were divided into two groups according to the CONUT score and the PNI.

Results: The five-year cancer-specific survival (CSS) rate was significantly higher at 92.7% in the low CONUT group, compared to a rate of 81.0% in the high CONUT group (p=0.0016). The five-year CSS was 71.2% in the low PNI group and 92.3% in the high PNI group, which showed a significant difference (p=0.0155). A multivariate analysis showed that lymph node metastasis and the CONUT score were independent risk factors for CSS.

Conclusion: This study suggested that the CONUT score is a strong independent predictor of the survival among CRC patients.

No MeSH data available.


Related in: MedlinePlus

The receiver operating characteristic (ROC) curve for the controlling nutritional status (CONUT).We used the continuous variable Controlling Nutritional Status (CONUT) as the test variable and 5-year cancer-specific survival as the state variable. An investigation of the cut-off value for the CONUT score using the receiver operating characteristic (ROC) curve showed the most appropriate cut-off value for the CONUT score to be 3 (AUC; 0.624, 95%CI: 0.476–0.771, p = 0.076, the sensitivity was 0.5263 and the specificity was 0.7622.). We indicated the ROC curve on Fig 1. Therefore, we set 3 as the cut-off value for the CONUT score in this study and classified the patients into high CONUT (≥3) and low CONUT (≤2) groups.
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pone.0132488.g001: The receiver operating characteristic (ROC) curve for the controlling nutritional status (CONUT).We used the continuous variable Controlling Nutritional Status (CONUT) as the test variable and 5-year cancer-specific survival as the state variable. An investigation of the cut-off value for the CONUT score using the receiver operating characteristic (ROC) curve showed the most appropriate cut-off value for the CONUT score to be 3 (AUC; 0.624, 95%CI: 0.476–0.771, p = 0.076, the sensitivity was 0.5263 and the specificity was 0.7622.). We indicated the ROC curve on Fig 1. Therefore, we set 3 as the cut-off value for the CONUT score in this study and classified the patients into high CONUT (≥3) and low CONUT (≤2) groups.

Mentions: We used the continuous variable Controlling Nutritional Status (CONUT) as the test variable and cancer-specific survival as the state variable. An investigation of the cut-off value for the CONUT score using the receiver operating characteristic (ROC) curve showed the most appropriate cut-off value for the CONUT score to be 3 (AUC; 0.624, 95%CI: 0.476–0.771, p = 0.076, the sensitivity was 0.5263 and the specificity was 0.7622.). We indicated the ROC curve on Fig 1. Therefore, we set 3 as the cut-off value for the CONUT score in this study and classified the patients into high CONUT (≥3) and low CONUT (≤2) groups.


Impact of the Preoperative Controlling Nutritional Status (CONUT) Score on the Survival after Curative Surgery for Colorectal Cancer.

Iseki Y, Shibutani M, Maeda K, Nagahara H, Ohtani H, Sugano K, Ikeya T, Muguruma K, Tanaka H, Toyokawa T, Sakurai K, Hirakawa K - PLoS ONE (2015)

The receiver operating characteristic (ROC) curve for the controlling nutritional status (CONUT).We used the continuous variable Controlling Nutritional Status (CONUT) as the test variable and 5-year cancer-specific survival as the state variable. An investigation of the cut-off value for the CONUT score using the receiver operating characteristic (ROC) curve showed the most appropriate cut-off value for the CONUT score to be 3 (AUC; 0.624, 95%CI: 0.476–0.771, p = 0.076, the sensitivity was 0.5263 and the specificity was 0.7622.). We indicated the ROC curve on Fig 1. Therefore, we set 3 as the cut-off value for the CONUT score in this study and classified the patients into high CONUT (≥3) and low CONUT (≤2) groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492767&req=5

pone.0132488.g001: The receiver operating characteristic (ROC) curve for the controlling nutritional status (CONUT).We used the continuous variable Controlling Nutritional Status (CONUT) as the test variable and 5-year cancer-specific survival as the state variable. An investigation of the cut-off value for the CONUT score using the receiver operating characteristic (ROC) curve showed the most appropriate cut-off value for the CONUT score to be 3 (AUC; 0.624, 95%CI: 0.476–0.771, p = 0.076, the sensitivity was 0.5263 and the specificity was 0.7622.). We indicated the ROC curve on Fig 1. Therefore, we set 3 as the cut-off value for the CONUT score in this study and classified the patients into high CONUT (≥3) and low CONUT (≤2) groups.
Mentions: We used the continuous variable Controlling Nutritional Status (CONUT) as the test variable and cancer-specific survival as the state variable. An investigation of the cut-off value for the CONUT score using the receiver operating characteristic (ROC) curve showed the most appropriate cut-off value for the CONUT score to be 3 (AUC; 0.624, 95%CI: 0.476–0.771, p = 0.076, the sensitivity was 0.5263 and the specificity was 0.7622.). We indicated the ROC curve on Fig 1. Therefore, we set 3 as the cut-off value for the CONUT score in this study and classified the patients into high CONUT (≥3) and low CONUT (≤2) groups.

Bottom Line: The five-year cancer-specific survival (CSS) rate was significantly higher at 92.7% in the low CONUT group, compared to a rate of 81.0% in the high CONUT group (p=0.0016).The five-year CSS was 71.2% in the low PNI group and 92.3% in the high PNI group, which showed a significant difference (p=0.0155).This study suggested that the CONUT score is a strong independent predictor of the survival among CRC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.

ABSTRACT

Background: Recently, the preoperative immune-nutritional status has been reported to correlate with the survival rate in patients with colorectal cancer (CRC). However, there have been no reports on the relationship between the controlling nutritional status (CONUT) score and the clinical outcome after curative surgery for CRC. We herein evaluated the prognostic significance of the CONUT score in patients with CRC, and then compared the accuracy of the CONUT score and the prognostic nutritional index (PNI) as a predictor of survival.

Methods: We retrospectively reviewed a database of 204 patients who underwent curative surgery for Stage II/III CRC. Patients were divided into two groups according to the CONUT score and the PNI.

Results: The five-year cancer-specific survival (CSS) rate was significantly higher at 92.7% in the low CONUT group, compared to a rate of 81.0% in the high CONUT group (p=0.0016). The five-year CSS was 71.2% in the low PNI group and 92.3% in the high PNI group, which showed a significant difference (p=0.0155). A multivariate analysis showed that lymph node metastasis and the CONUT score were independent risk factors for CSS.

Conclusion: This study suggested that the CONUT score is a strong independent predictor of the survival among CRC patients.

No MeSH data available.


Related in: MedlinePlus