Limits...
Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis.

Labib GS, Aldawsari H - Drug Des Devel Ther (2015)

Bottom Line: This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors.All bases showed appreciable adhesion in the in vitro and ex vivo studies.The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

ABSTRACT

Purpose: Oral candidiasis may be manifested in the oral cavity as either mild or severe oral fungal infection. This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors. Several aspects have spurred the search for new strategies in the treatment of oral candidiasis, among which are the limited numbers of new antifungal drugs developed in recent years. Previous studies have shown that thyme and clove oils have antimycotic activities and have suggested their incorporation into pharmaceutical preparations. This study aimed to investigate the possibility of the incorporation and characterization of essential oils or their extracted active ingredients in Orabase formulations.

Methods: Orabase loaded with clove oil, thyme oil, eugenol, and thymol were prepared and evaluated for their antifungal activities, pH, viscosity, erosion and water uptake characteristics, mechanical properties, in vitro release behavior, and ex vivo mucoadhesion properties.

Results: All prepared bases showed considerable antifungal activity and acceptable physical characteristics. The release pattern from loaded bases was considerably slow for all oils and active ingredients. All bases showed appreciable adhesion in the in vitro and ex vivo studies.

Conclusion: The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

No MeSH data available.


Related in: MedlinePlus

Comparative agar-adhesiveness study on the nonloaded and loaded Orabase formulations.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4492630&req=5

f6-dddt-9-3349: Comparative agar-adhesiveness study on the nonloaded and loaded Orabase formulations.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.

Mentions: Moderate increase in spreadability was observed for all prepared bases under study (Figure 4). Both the shear stress required to move the plate and the adhesiveness was in the following order (Figures 5 and 6): Placebo > Eug > Cl > TH > Thy.


Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis.

Labib GS, Aldawsari H - Drug Des Devel Ther (2015)

Comparative agar-adhesiveness study on the nonloaded and loaded Orabase formulations.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492630&req=5

f6-dddt-9-3349: Comparative agar-adhesiveness study on the nonloaded and loaded Orabase formulations.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.
Mentions: Moderate increase in spreadability was observed for all prepared bases under study (Figure 4). Both the shear stress required to move the plate and the adhesiveness was in the following order (Figures 5 and 6): Placebo > Eug > Cl > TH > Thy.

Bottom Line: This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors.All bases showed appreciable adhesion in the in vitro and ex vivo studies.The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

ABSTRACT

Purpose: Oral candidiasis may be manifested in the oral cavity as either mild or severe oral fungal infection. This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors. Several aspects have spurred the search for new strategies in the treatment of oral candidiasis, among which are the limited numbers of new antifungal drugs developed in recent years. Previous studies have shown that thyme and clove oils have antimycotic activities and have suggested their incorporation into pharmaceutical preparations. This study aimed to investigate the possibility of the incorporation and characterization of essential oils or their extracted active ingredients in Orabase formulations.

Methods: Orabase loaded with clove oil, thyme oil, eugenol, and thymol were prepared and evaluated for their antifungal activities, pH, viscosity, erosion and water uptake characteristics, mechanical properties, in vitro release behavior, and ex vivo mucoadhesion properties.

Results: All prepared bases showed considerable antifungal activity and acceptable physical characteristics. The release pattern from loaded bases was considerably slow for all oils and active ingredients. All bases showed appreciable adhesion in the in vitro and ex vivo studies.

Conclusion: The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

No MeSH data available.


Related in: MedlinePlus