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Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis.

Labib GS, Aldawsari H - Drug Des Devel Ther (2015)

Bottom Line: This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors.All bases showed appreciable adhesion in the in vitro and ex vivo studies.The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

ABSTRACT

Purpose: Oral candidiasis may be manifested in the oral cavity as either mild or severe oral fungal infection. This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors. Several aspects have spurred the search for new strategies in the treatment of oral candidiasis, among which are the limited numbers of new antifungal drugs developed in recent years. Previous studies have shown that thyme and clove oils have antimycotic activities and have suggested their incorporation into pharmaceutical preparations. This study aimed to investigate the possibility of the incorporation and characterization of essential oils or their extracted active ingredients in Orabase formulations.

Methods: Orabase loaded with clove oil, thyme oil, eugenol, and thymol were prepared and evaluated for their antifungal activities, pH, viscosity, erosion and water uptake characteristics, mechanical properties, in vitro release behavior, and ex vivo mucoadhesion properties.

Results: All prepared bases showed considerable antifungal activity and acceptable physical characteristics. The release pattern from loaded bases was considerably slow for all oils and active ingredients. All bases showed appreciable adhesion in the in vitro and ex vivo studies.

Conclusion: The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

No MeSH data available.


Related in: MedlinePlus

Percentage cumulative release profiles of the active ingredients from the prepared loaded Orabase formulations.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.
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f3-dddt-9-3349: Percentage cumulative release profiles of the active ingredients from the prepared loaded Orabase formulations.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.

Mentions: The in vitro release of Cl from Orabase was more pronounced initially for the first hour compared to the release of Eug. In the case of TH oil, there was a general increase in the release rate compared to Thy release profile, reaching about 90% by the end of the study. After the 3rd hour of release, Cl, Eug, and Thy release profiles were comparable to each other until the end of experiment, whereby nearly all of them released 60% of their content (Figure 3). The release kinetics calculated for all formulations showed a mixed mechanism of release in most cases (Table 3).


Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis.

Labib GS, Aldawsari H - Drug Des Devel Ther (2015)

Percentage cumulative release profiles of the active ingredients from the prepared loaded Orabase formulations.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492630&req=5

f3-dddt-9-3349: Percentage cumulative release profiles of the active ingredients from the prepared loaded Orabase formulations.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.
Mentions: The in vitro release of Cl from Orabase was more pronounced initially for the first hour compared to the release of Eug. In the case of TH oil, there was a general increase in the release rate compared to Thy release profile, reaching about 90% by the end of the study. After the 3rd hour of release, Cl, Eug, and Thy release profiles were comparable to each other until the end of experiment, whereby nearly all of them released 60% of their content (Figure 3). The release kinetics calculated for all formulations showed a mixed mechanism of release in most cases (Table 3).

Bottom Line: This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors.All bases showed appreciable adhesion in the in vitro and ex vivo studies.The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

ABSTRACT

Purpose: Oral candidiasis may be manifested in the oral cavity as either mild or severe oral fungal infection. This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors. Several aspects have spurred the search for new strategies in the treatment of oral candidiasis, among which are the limited numbers of new antifungal drugs developed in recent years. Previous studies have shown that thyme and clove oils have antimycotic activities and have suggested their incorporation into pharmaceutical preparations. This study aimed to investigate the possibility of the incorporation and characterization of essential oils or their extracted active ingredients in Orabase formulations.

Methods: Orabase loaded with clove oil, thyme oil, eugenol, and thymol were prepared and evaluated for their antifungal activities, pH, viscosity, erosion and water uptake characteristics, mechanical properties, in vitro release behavior, and ex vivo mucoadhesion properties.

Results: All prepared bases showed considerable antifungal activity and acceptable physical characteristics. The release pattern from loaded bases was considerably slow for all oils and active ingredients. All bases showed appreciable adhesion in the in vitro and ex vivo studies.

Conclusion: The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

No MeSH data available.


Related in: MedlinePlus