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Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis.

Labib GS, Aldawsari H - Drug Des Devel Ther (2015)

Bottom Line: This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors.All bases showed appreciable adhesion in the in vitro and ex vivo studies.The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

ABSTRACT

Purpose: Oral candidiasis may be manifested in the oral cavity as either mild or severe oral fungal infection. This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors. Several aspects have spurred the search for new strategies in the treatment of oral candidiasis, among which are the limited numbers of new antifungal drugs developed in recent years. Previous studies have shown that thyme and clove oils have antimycotic activities and have suggested their incorporation into pharmaceutical preparations. This study aimed to investigate the possibility of the incorporation and characterization of essential oils or their extracted active ingredients in Orabase formulations.

Methods: Orabase loaded with clove oil, thyme oil, eugenol, and thymol were prepared and evaluated for their antifungal activities, pH, viscosity, erosion and water uptake characteristics, mechanical properties, in vitro release behavior, and ex vivo mucoadhesion properties.

Results: All prepared bases showed considerable antifungal activity and acceptable physical characteristics. The release pattern from loaded bases was considerably slow for all oils and active ingredients. All bases showed appreciable adhesion in the in vitro and ex vivo studies.

Conclusion: The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

No MeSH data available.


Related in: MedlinePlus

Percentage cumulative erosion and water uptake by the prepared loaded Orabase formulations in comparison to the nonloaded base.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.
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f2-dddt-9-3349: Percentage cumulative erosion and water uptake by the prepared loaded Orabase formulations in comparison to the nonloaded base.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.

Mentions: The water uptake and erosion profiles are presented in Figure 2. It could be observed that the nonloaded base showed erosion resistance properties when compared to the loaded ones. Cl Orabase showed slow water uptake for the 1st hour, after which erosion started at a very slow rate, reaching 12% cumulative erosion by the end of the study. This effect was less pronounced with Eug-loaded Orabase, whereby the base showed slow water uptake for the first half hour, followed by a higher erosion rate, reaching about 65% cumulative erosion by the end of the study. As for TH oil- and Thy-loaded bases, they had nearly the same behavioral patterns of erosion from the start of the experiment to the end, with lower extent in the case of the latter, reaching 98% and 80% cumulative erosion, respectively.


Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis.

Labib GS, Aldawsari H - Drug Des Devel Ther (2015)

Percentage cumulative erosion and water uptake by the prepared loaded Orabase formulations in comparison to the nonloaded base.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492630&req=5

f2-dddt-9-3349: Percentage cumulative erosion and water uptake by the prepared loaded Orabase formulations in comparison to the nonloaded base.Abbreviations: Cl, clove oil; Eug, eugenol; Orab, Orabase; TH, thyme oil; Thy, thymol.
Mentions: The water uptake and erosion profiles are presented in Figure 2. It could be observed that the nonloaded base showed erosion resistance properties when compared to the loaded ones. Cl Orabase showed slow water uptake for the 1st hour, after which erosion started at a very slow rate, reaching 12% cumulative erosion by the end of the study. This effect was less pronounced with Eug-loaded Orabase, whereby the base showed slow water uptake for the first half hour, followed by a higher erosion rate, reaching about 65% cumulative erosion by the end of the study. As for TH oil- and Thy-loaded bases, they had nearly the same behavioral patterns of erosion from the start of the experiment to the end, with lower extent in the case of the latter, reaching 98% and 80% cumulative erosion, respectively.

Bottom Line: This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors.All bases showed appreciable adhesion in the in vitro and ex vivo studies.The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

ABSTRACT

Purpose: Oral candidiasis may be manifested in the oral cavity as either mild or severe oral fungal infection. This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors. Several aspects have spurred the search for new strategies in the treatment of oral candidiasis, among which are the limited numbers of new antifungal drugs developed in recent years. Previous studies have shown that thyme and clove oils have antimycotic activities and have suggested their incorporation into pharmaceutical preparations. This study aimed to investigate the possibility of the incorporation and characterization of essential oils or their extracted active ingredients in Orabase formulations.

Methods: Orabase loaded with clove oil, thyme oil, eugenol, and thymol were prepared and evaluated for their antifungal activities, pH, viscosity, erosion and water uptake characteristics, mechanical properties, in vitro release behavior, and ex vivo mucoadhesion properties.

Results: All prepared bases showed considerable antifungal activity and acceptable physical characteristics. The release pattern from loaded bases was considerably slow for all oils and active ingredients. All bases showed appreciable adhesion in the in vitro and ex vivo studies.

Conclusion: The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.

No MeSH data available.


Related in: MedlinePlus