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Mating Reverses Actuarial Aging in Female Queensland Fruit Flies.

Yap S, Fanson BG, Taylor PW - PLoS ONE (2015)

Bottom Line: In a remarkable exception, one tephritid fruit fly exhibits substantial pre-reproductive aging but then mitigates this aging during a diet-dependent transition to the reproductive stage, after which life expectancy matches that of newly emerged flies.Here, we ascertain the role of nutrients, sexual maturation and mating in mitigation of previous aging in female Queensland fruit flies.Identifying the physiological processes associated with mating promise novel insights into repair mechanisms for aging.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia.

ABSTRACT
Animals that have a long pre-reproductive adult stage often employ mechanisms that minimize aging over this period in order to preserve reproductive lifespan. In a remarkable exception, one tephritid fruit fly exhibits substantial pre-reproductive aging but then mitigates this aging during a diet-dependent transition to the reproductive stage, after which life expectancy matches that of newly emerged flies. Here, we ascertain the role of nutrients, sexual maturation and mating in mitigation of previous aging in female Queensland fruit flies. Flies were provided one of three diets: 'sugar', 'essential', or 'yeast-sugar'. Essential diet contained sugar and micronutrients found in yeast but lacked maturation-enabling protein. At days 20 and 30, a subset of flies on the sugar diet were switched to essential or yeast-sugar diet, and some yeast-sugar fed flies were mated 10 days later. Complete mitigation of actuarial aging was only observed in flies that were switched to a yeast-sugar diet and mated, indicating that mating is key. Identifying the physiological processes associated with mating promise novel insights into repair mechanisms for aging.

No MeSH data available.


Egg production rates at 5-day intervals for YS 0, 20 and 30 mated (a) and unmated (b) flies that laid eggs.For YS 0, 20 and 30 mated and unmated flies, the x-axis has been rescaled so that day 0 represents day 10, 30 and 40 respectively (Day 10 in red; Day 30 in green, Day 40 in blue). Standard error bars are plotted at every 5-day interval and asterisk indicates significant difference (P<0.05) among treatments.
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pone.0132486.g002: Egg production rates at 5-day intervals for YS 0, 20 and 30 mated (a) and unmated (b) flies that laid eggs.For YS 0, 20 and 30 mated and unmated flies, the x-axis has been rescaled so that day 0 represents day 10, 30 and 40 respectively (Day 10 in red; Day 30 in green, Day 40 in blue). Standard error bars are plotted at every 5-day interval and asterisk indicates significant difference (P<0.05) among treatments.

Mentions: The age at which flies were switched to the YS diet affected egg production rates (Fig 2A and 2B, YS-M: F25,482 = 1.55, p = 0.04; YS-U: F23,378 = 2.20, p = 0.001 respectively). YS-0-M and YS-20-M flies had higher egg laying during the first 5 days after switching compared to YS-30-M flies (Fig 2A, F2,375 = 7.07, p = 0.002). YS-0-U and YS-20-U had higher egg laying for the first 5 days after switching compared to YS-30-U (Fig 2B, F2,336 = 10.32, p < 0.001). YS-20-U maintained a high rate of egg production up until the 10th day after switching whereas egg production for YS-0-U was lowered (F2,347 = 4.79, p = 0.009). After this time, there were no differences in egg production rates for YS 0, 20 and 30 mated and unmated flies (Fig 2A and 2B).


Mating Reverses Actuarial Aging in Female Queensland Fruit Flies.

Yap S, Fanson BG, Taylor PW - PLoS ONE (2015)

Egg production rates at 5-day intervals for YS 0, 20 and 30 mated (a) and unmated (b) flies that laid eggs.For YS 0, 20 and 30 mated and unmated flies, the x-axis has been rescaled so that day 0 represents day 10, 30 and 40 respectively (Day 10 in red; Day 30 in green, Day 40 in blue). Standard error bars are plotted at every 5-day interval and asterisk indicates significant difference (P<0.05) among treatments.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492602&req=5

pone.0132486.g002: Egg production rates at 5-day intervals for YS 0, 20 and 30 mated (a) and unmated (b) flies that laid eggs.For YS 0, 20 and 30 mated and unmated flies, the x-axis has been rescaled so that day 0 represents day 10, 30 and 40 respectively (Day 10 in red; Day 30 in green, Day 40 in blue). Standard error bars are plotted at every 5-day interval and asterisk indicates significant difference (P<0.05) among treatments.
Mentions: The age at which flies were switched to the YS diet affected egg production rates (Fig 2A and 2B, YS-M: F25,482 = 1.55, p = 0.04; YS-U: F23,378 = 2.20, p = 0.001 respectively). YS-0-M and YS-20-M flies had higher egg laying during the first 5 days after switching compared to YS-30-M flies (Fig 2A, F2,375 = 7.07, p = 0.002). YS-0-U and YS-20-U had higher egg laying for the first 5 days after switching compared to YS-30-U (Fig 2B, F2,336 = 10.32, p < 0.001). YS-20-U maintained a high rate of egg production up until the 10th day after switching whereas egg production for YS-0-U was lowered (F2,347 = 4.79, p = 0.009). After this time, there were no differences in egg production rates for YS 0, 20 and 30 mated and unmated flies (Fig 2A and 2B).

Bottom Line: In a remarkable exception, one tephritid fruit fly exhibits substantial pre-reproductive aging but then mitigates this aging during a diet-dependent transition to the reproductive stage, after which life expectancy matches that of newly emerged flies.Here, we ascertain the role of nutrients, sexual maturation and mating in mitigation of previous aging in female Queensland fruit flies.Identifying the physiological processes associated with mating promise novel insights into repair mechanisms for aging.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia.

ABSTRACT
Animals that have a long pre-reproductive adult stage often employ mechanisms that minimize aging over this period in order to preserve reproductive lifespan. In a remarkable exception, one tephritid fruit fly exhibits substantial pre-reproductive aging but then mitigates this aging during a diet-dependent transition to the reproductive stage, after which life expectancy matches that of newly emerged flies. Here, we ascertain the role of nutrients, sexual maturation and mating in mitigation of previous aging in female Queensland fruit flies. Flies were provided one of three diets: 'sugar', 'essential', or 'yeast-sugar'. Essential diet contained sugar and micronutrients found in yeast but lacked maturation-enabling protein. At days 20 and 30, a subset of flies on the sugar diet were switched to essential or yeast-sugar diet, and some yeast-sugar fed flies were mated 10 days later. Complete mitigation of actuarial aging was only observed in flies that were switched to a yeast-sugar diet and mated, indicating that mating is key. Identifying the physiological processes associated with mating promise novel insights into repair mechanisms for aging.

No MeSH data available.