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Genetic Case-Control Study for Eight Polymorphisms Associated with Rheumatoid Arthritis.

Saad MN, Mabrouk MS, Eldeib AM, Shaker OG - PLoS ONE (2015)

Bottom Line: TGFβ1 and MTHFR A1298C were associated with RA using the dominant and the co-dominant models.There were no significant differences for FokI and the presence of RA disease by the used models examination.For LD results, There was a high D' value between BsmI and FokI (D' = 0.91), but the r(2) value between them was poor.

View Article: PubMed Central - PubMed

Affiliation: Biomedical Engineering Department, Minia University, Minia, Egypt.

ABSTRACT
Rheumatoid arthritis (RA) is an autoimmune disease which has a significant socio-economic impact. The aim of the current study was to investigate eight candidate RA susceptibility loci to identify the associated variants in Egyptian population. Eight single nucleotide polymorphisms (SNPs) (MTHFR-C677T and A1298C, TGFβ1 T869C, TNFB A252G, and VDR-ApaI, BsmI, FokI, and TaqI) were tested by genotyping patients with RA (n = 105) and unrelated controls (n = 80). Associations were tested using multiplicative, dominant, recessive, and co-dominant models. Also, the linkage disequilibrium (LD) between the VDR SNPs was measured to detect any indirect association. By comparing RA patients with controls (TNFB, BsmI, and TaqI), SNPs were associated with RA using all models. MTHFR C677T was associated with RA using all models except the recessive model. TGFβ1 and MTHFR A1298C were associated with RA using the dominant and the co-dominant models. The recessive model represented the association for ApaI variant. There were no significant differences for FokI and the presence of RA disease by the used models examination. For LD results, There was a high D' value between BsmI and FokI (D' = 0.91), but the r(2) value between them was poor. All the studied SNPs may contribute to the susceptibility of RA disease in Egyptian population except for FokI SNP.

No MeSH data available.


Related in: MedlinePlus

Association Analyses for Examined SNPs with RA Disease.(a) Multiplicative model. (b) Dominant model. (c) Recessive model. (d) Co-dominant model. The horizontal line in each model represents the significance level of the P value (0.01). The figure was generated using the SNPAnalyzer 2.0 program.
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pone.0131960.g002: Association Analyses for Examined SNPs with RA Disease.(a) Multiplicative model. (b) Dominant model. (c) Recessive model. (d) Co-dominant model. The horizontal line in each model represents the significance level of the P value (0.01). The figure was generated using the SNPAnalyzer 2.0 program.

Mentions: Table 3 represented the association between the examined SNPs and RA disease. A graphical representation of the association results for the studied SNPs was shown in Fig 2. The red color in Fig 2 demonstrated a statistically significant SNP. From Table 3 and Fig 2, TNFB, BsmI, and TaqI showed significant association with RA susceptibility with the four used models. MTHFR C677T expressed significant association with RA susceptibility with all models except the recessive model. TGFβ1 and MTHFR A1298C showed significant association with RA susceptibility with the dominant and co-dominant models. ApaI imposed significant association with RA susceptibility with only the recessive model. FokI did not show any significant association with RA directly with any of the used models.


Genetic Case-Control Study for Eight Polymorphisms Associated with Rheumatoid Arthritis.

Saad MN, Mabrouk MS, Eldeib AM, Shaker OG - PLoS ONE (2015)

Association Analyses for Examined SNPs with RA Disease.(a) Multiplicative model. (b) Dominant model. (c) Recessive model. (d) Co-dominant model. The horizontal line in each model represents the significance level of the P value (0.01). The figure was generated using the SNPAnalyzer 2.0 program.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492599&req=5

pone.0131960.g002: Association Analyses for Examined SNPs with RA Disease.(a) Multiplicative model. (b) Dominant model. (c) Recessive model. (d) Co-dominant model. The horizontal line in each model represents the significance level of the P value (0.01). The figure was generated using the SNPAnalyzer 2.0 program.
Mentions: Table 3 represented the association between the examined SNPs and RA disease. A graphical representation of the association results for the studied SNPs was shown in Fig 2. The red color in Fig 2 demonstrated a statistically significant SNP. From Table 3 and Fig 2, TNFB, BsmI, and TaqI showed significant association with RA susceptibility with the four used models. MTHFR C677T expressed significant association with RA susceptibility with all models except the recessive model. TGFβ1 and MTHFR A1298C showed significant association with RA susceptibility with the dominant and co-dominant models. ApaI imposed significant association with RA susceptibility with only the recessive model. FokI did not show any significant association with RA directly with any of the used models.

Bottom Line: TGFβ1 and MTHFR A1298C were associated with RA using the dominant and the co-dominant models.There were no significant differences for FokI and the presence of RA disease by the used models examination.For LD results, There was a high D' value between BsmI and FokI (D' = 0.91), but the r(2) value between them was poor.

View Article: PubMed Central - PubMed

Affiliation: Biomedical Engineering Department, Minia University, Minia, Egypt.

ABSTRACT
Rheumatoid arthritis (RA) is an autoimmune disease which has a significant socio-economic impact. The aim of the current study was to investigate eight candidate RA susceptibility loci to identify the associated variants in Egyptian population. Eight single nucleotide polymorphisms (SNPs) (MTHFR-C677T and A1298C, TGFβ1 T869C, TNFB A252G, and VDR-ApaI, BsmI, FokI, and TaqI) were tested by genotyping patients with RA (n = 105) and unrelated controls (n = 80). Associations were tested using multiplicative, dominant, recessive, and co-dominant models. Also, the linkage disequilibrium (LD) between the VDR SNPs was measured to detect any indirect association. By comparing RA patients with controls (TNFB, BsmI, and TaqI), SNPs were associated with RA using all models. MTHFR C677T was associated with RA using all models except the recessive model. TGFβ1 and MTHFR A1298C were associated with RA using the dominant and the co-dominant models. The recessive model represented the association for ApaI variant. There were no significant differences for FokI and the presence of RA disease by the used models examination. For LD results, There was a high D' value between BsmI and FokI (D' = 0.91), but the r(2) value between them was poor. All the studied SNPs may contribute to the susceptibility of RA disease in Egyptian population except for FokI SNP.

No MeSH data available.


Related in: MedlinePlus