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Renal cell carcinoma: histological classification and correlation with imaging findings.

Muglia VF, Prando A - Radiol Bras (2015 May-Jun)

Bottom Line: The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes.The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Postdoctoral Scholar, Associate Professor at Centro de Ciências das Imagens e Física Médica (CCIFM) - Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

ABSTRACT
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.

No MeSH data available.


Related in: MedlinePlus

Renal mucinous tubular and spindle cell carcinoma. Female, 57-year-old patientwith hematuria. A: MRI, T2-weighted image showing expansile lesionwith intermediate signal intensity, and (B) contrast-enhancednephrographic phase showing hypovascular lesion – compare with the cortex (arrow).Observe the hyposignal of the scar (asterisk). Despite the large dimensions of thelesion, it is well delimited, with no infiltrating feature. C:Surgical specimen showing a circumscribed, yellowish lesion with central scar(asterisk).
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f10: Renal mucinous tubular and spindle cell carcinoma. Female, 57-year-old patientwith hematuria. A: MRI, T2-weighted image showing expansile lesionwith intermediate signal intensity, and (B) contrast-enhancednephrographic phase showing hypovascular lesion – compare with the cortex (arrow).Observe the hyposignal of the scar (asterisk). Despite the large dimensions of thelesion, it is well delimited, with no infiltrating feature. C:Surgical specimen showing a circumscribed, yellowish lesion with central scar(asterisk).

Mentions: At imaging studies, MTSCCs do not present any typical feature, and in the few casesreported until de present moment they appear as circumscribed nodules or massesincidentally found at ultrasonography and CT. Typically, these tumors tend to behomogeneous, with low signal intensity at T1-weighted sequences and intermediate toslightly hyperintense signal at T2-weighted sequences(22). Some of these lesions may present with an irregularcentral scar. After intravenous contrast agent injection, it is hypovascular in relationto the adjacent cortex, and in cases where a central scar is present (Figure 10) the tumor may present variableopacification degrees(33).


Renal cell carcinoma: histological classification and correlation with imaging findings.

Muglia VF, Prando A - Radiol Bras (2015 May-Jun)

Renal mucinous tubular and spindle cell carcinoma. Female, 57-year-old patientwith hematuria. A: MRI, T2-weighted image showing expansile lesionwith intermediate signal intensity, and (B) contrast-enhancednephrographic phase showing hypovascular lesion – compare with the cortex (arrow).Observe the hyposignal of the scar (asterisk). Despite the large dimensions of thelesion, it is well delimited, with no infiltrating feature. C:Surgical specimen showing a circumscribed, yellowish lesion with central scar(asterisk).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492569&req=5

f10: Renal mucinous tubular and spindle cell carcinoma. Female, 57-year-old patientwith hematuria. A: MRI, T2-weighted image showing expansile lesionwith intermediate signal intensity, and (B) contrast-enhancednephrographic phase showing hypovascular lesion – compare with the cortex (arrow).Observe the hyposignal of the scar (asterisk). Despite the large dimensions of thelesion, it is well delimited, with no infiltrating feature. C:Surgical specimen showing a circumscribed, yellowish lesion with central scar(asterisk).
Mentions: At imaging studies, MTSCCs do not present any typical feature, and in the few casesreported until de present moment they appear as circumscribed nodules or massesincidentally found at ultrasonography and CT. Typically, these tumors tend to behomogeneous, with low signal intensity at T1-weighted sequences and intermediate toslightly hyperintense signal at T2-weighted sequences(22). Some of these lesions may present with an irregularcentral scar. After intravenous contrast agent injection, it is hypovascular in relationto the adjacent cortex, and in cases where a central scar is present (Figure 10) the tumor may present variableopacification degrees(33).

Bottom Line: The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes.The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Postdoctoral Scholar, Associate Professor at Centro de Ciências das Imagens e Física Médica (CCIFM) - Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

ABSTRACT
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.

No MeSH data available.


Related in: MedlinePlus