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Renal cell carcinoma: histological classification and correlation with imaging findings.

Muglia VF, Prando A - Radiol Bras (2015 May-Jun)

Bottom Line: The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes.The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Postdoctoral Scholar, Associate Professor at Centro de Ciências das Imagens e Física Médica (CCIFM) - Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

ABSTRACT
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.

No MeSH data available.


Related in: MedlinePlus

Collecting duct RCC. A: MRI, coronal plane, T2-weighted image showingexpansile, irregular lesion in the upper pole of left kidney, with heterogeneoussignal intensity and predominance of hyposignal (asterisk). B:Contrast-enhanced MRI, axial, T1-weighted image. The lesion presents predominantlyperipheral, heterogeneous signal intensity, considerably less intense than therenal cortex.
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f07: Collecting duct RCC. A: MRI, coronal plane, T2-weighted image showingexpansile, irregular lesion in the upper pole of left kidney, with heterogeneoussignal intensity and predominance of hyposignal (asterisk). B:Contrast-enhanced MRI, axial, T1-weighted image. The lesion presents predominantlyperipheral, heterogeneous signal intensity, considerably less intense than therenal cortex.

Mentions: Histologically, collecting duct renal cell carcinoma (cdRCC) is characterized by anirregular, infiltrating cells arrangement in the collecting duct walls, showingremarkable desmoplasia(13). A subtlemale prevalence is observed, and in general such lesions show up after the fifth decadeof life. At imaging studies, cdRCCs appear as heterogeneous lesions with extremelyvariable signal intensity on T2-weighted sequences, depending on the amount ofhemorrhage, necrosis, cystic component and calcification; and frequently presenthyposignal at those sequences (Figure 7). Ingeneral, and typically, the lesions originate in the medulla, implying a differentialdiagnosis with transitional cell carcinoma(28). Larger lesions may invade the cortex. Most of these lesions aresolid, but some of them may present as complex lesions(26). They are hypovascular at multidetector CT as well asat MRI, tending to heterogeneous or peripheral contrast uptake.


Renal cell carcinoma: histological classification and correlation with imaging findings.

Muglia VF, Prando A - Radiol Bras (2015 May-Jun)

Collecting duct RCC. A: MRI, coronal plane, T2-weighted image showingexpansile, irregular lesion in the upper pole of left kidney, with heterogeneoussignal intensity and predominance of hyposignal (asterisk). B:Contrast-enhanced MRI, axial, T1-weighted image. The lesion presents predominantlyperipheral, heterogeneous signal intensity, considerably less intense than therenal cortex.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492569&req=5

f07: Collecting duct RCC. A: MRI, coronal plane, T2-weighted image showingexpansile, irregular lesion in the upper pole of left kidney, with heterogeneoussignal intensity and predominance of hyposignal (asterisk). B:Contrast-enhanced MRI, axial, T1-weighted image. The lesion presents predominantlyperipheral, heterogeneous signal intensity, considerably less intense than therenal cortex.
Mentions: Histologically, collecting duct renal cell carcinoma (cdRCC) is characterized by anirregular, infiltrating cells arrangement in the collecting duct walls, showingremarkable desmoplasia(13). A subtlemale prevalence is observed, and in general such lesions show up after the fifth decadeof life. At imaging studies, cdRCCs appear as heterogeneous lesions with extremelyvariable signal intensity on T2-weighted sequences, depending on the amount ofhemorrhage, necrosis, cystic component and calcification; and frequently presenthyposignal at those sequences (Figure 7). Ingeneral, and typically, the lesions originate in the medulla, implying a differentialdiagnosis with transitional cell carcinoma(28). Larger lesions may invade the cortex. Most of these lesions aresolid, but some of them may present as complex lesions(26). They are hypovascular at multidetector CT as well asat MRI, tending to heterogeneous or peripheral contrast uptake.

Bottom Line: The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes.The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Postdoctoral Scholar, Associate Professor at Centro de Ciências das Imagens e Física Médica (CCIFM) - Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

ABSTRACT
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.

No MeSH data available.


Related in: MedlinePlus