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Renal cell carcinoma: histological classification and correlation with imaging findings.

Muglia VF, Prando A - Radiol Bras (2015 May-Jun)

Bottom Line: The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes.The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Postdoctoral Scholar, Associate Professor at Centro de Ciências das Imagens e Física Médica (CCIFM) - Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

ABSTRACT
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.

No MeSH data available.


Related in: MedlinePlus

Histology of the most common RCC subtypes. A: Clear cell RCC – cellswith lipid-rich ample cytoplasm, hence the name of the neoplasm. B:Type 1 Papillary RCC – small basophilic cells with scarce cytoplasm, organized ina spindle-shaped pattern, in a single layer of cells surrounding the basalmembrane. C: Type 2 Papillary RCC – cells organized in aspindle-shaped pattern with papillae covered by cells with abundant eosinophilicgranular cytoplasm with prominent nucleoli. D: Chromophobe RCC –large pale cells with reticulated cytoplasm and perinuclear halos. E:Collecting duct RCC – histology shows an irregular, infiltrating cells arrangementin the collecting duct walls, showing remarkable desmoplasia. F:Medullary RCC – it originates in the distal nephron, also with an irregular cellarrangement, remarkable pleomorphism and hyperchromatic nuclei.
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f01: Histology of the most common RCC subtypes. A: Clear cell RCC – cellswith lipid-rich ample cytoplasm, hence the name of the neoplasm. B:Type 1 Papillary RCC – small basophilic cells with scarce cytoplasm, organized ina spindle-shaped pattern, in a single layer of cells surrounding the basalmembrane. C: Type 2 Papillary RCC – cells organized in aspindle-shaped pattern with papillae covered by cells with abundant eosinophilicgranular cytoplasm with prominent nucleoli. D: Chromophobe RCC –large pale cells with reticulated cytoplasm and perinuclear halos. E:Collecting duct RCC – histology shows an irregular, infiltrating cells arrangementin the collecting duct walls, showing remarkable desmoplasia. F:Medullary RCC – it originates in the distal nephron, also with an irregular cellarrangement, remarkable pleomorphism and hyperchromatic nuclei.

Mentions: About two decades ago, RCCs were divided between clear cell and granular cellvariants(3). Currently,according to the 2004 WHO classification, several histological RCC subtypes arerecognized (Table 1). The most frequenthistological subtypes include clear cell renal cell carcinomas (ccRCC), papillary renalcell carcinomas (pRCC), and chromophobe renal cell carcinomas (crRCC) (Figure 1). These three subtypes together representmore than 90% of all RCCs(11).


Renal cell carcinoma: histological classification and correlation with imaging findings.

Muglia VF, Prando A - Radiol Bras (2015 May-Jun)

Histology of the most common RCC subtypes. A: Clear cell RCC – cellswith lipid-rich ample cytoplasm, hence the name of the neoplasm. B:Type 1 Papillary RCC – small basophilic cells with scarce cytoplasm, organized ina spindle-shaped pattern, in a single layer of cells surrounding the basalmembrane. C: Type 2 Papillary RCC – cells organized in aspindle-shaped pattern with papillae covered by cells with abundant eosinophilicgranular cytoplasm with prominent nucleoli. D: Chromophobe RCC –large pale cells with reticulated cytoplasm and perinuclear halos. E:Collecting duct RCC – histology shows an irregular, infiltrating cells arrangementin the collecting duct walls, showing remarkable desmoplasia. F:Medullary RCC – it originates in the distal nephron, also with an irregular cellarrangement, remarkable pleomorphism and hyperchromatic nuclei.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492569&req=5

f01: Histology of the most common RCC subtypes. A: Clear cell RCC – cellswith lipid-rich ample cytoplasm, hence the name of the neoplasm. B:Type 1 Papillary RCC – small basophilic cells with scarce cytoplasm, organized ina spindle-shaped pattern, in a single layer of cells surrounding the basalmembrane. C: Type 2 Papillary RCC – cells organized in aspindle-shaped pattern with papillae covered by cells with abundant eosinophilicgranular cytoplasm with prominent nucleoli. D: Chromophobe RCC –large pale cells with reticulated cytoplasm and perinuclear halos. E:Collecting duct RCC – histology shows an irregular, infiltrating cells arrangementin the collecting duct walls, showing remarkable desmoplasia. F:Medullary RCC – it originates in the distal nephron, also with an irregular cellarrangement, remarkable pleomorphism and hyperchromatic nuclei.
Mentions: About two decades ago, RCCs were divided between clear cell and granular cellvariants(3). Currently,according to the 2004 WHO classification, several histological RCC subtypes arerecognized (Table 1). The most frequenthistological subtypes include clear cell renal cell carcinomas (ccRCC), papillary renalcell carcinomas (pRCC), and chromophobe renal cell carcinomas (crRCC) (Figure 1). These three subtypes together representmore than 90% of all RCCs(11).

Bottom Line: The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes.The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Postdoctoral Scholar, Associate Professor at Centro de Ciências das Imagens e Física Médica (CCIFM) - Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

ABSTRACT
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.

No MeSH data available.


Related in: MedlinePlus