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Relationships between Depressive Symptoms and Endothelial Function Among Outpatients of a General Hospital in China.

Shi H, Feng G, Wang Z, Zhou C, Zhong G, Hu Y, Wang G - Med. Sci. Monit. (2015)

Bottom Line: The mean RHI was 1.93, 2.34, and 2.19 in depression, control, and remission groups, respectively, showing a significant difference among the 3 groups (P=0.0004).However, there was no significant difference between remission and control groups (P=0.3363).There is a relationship between depression and endothelial dysfunction in outpatients from a general hospital in China.

View Article: PubMed Central - PubMed

Affiliation: Depression Treatment Center, Beijing An Ding Hospital, Capital Medical University, Beijing, China (mainland).

ABSTRACT

Background: This study aimed to investigate the endothelial function by reactive hyperemia index (RHI) in patients with depression, subjects recovering from depression, and subjects without a history of depression.

Material and methods: Outpatients were recruited from a general hospital in China; 62 patients diagnosed with depression and the 17-item Hamilton Rating Scale for Depression (HAMD17) total scores ≥17 were enrolled as the depression group, 62 patients with a history of depression, discontinuation of antidepressants therapy at least 3 months ago, and HAMD17 ≤7 were recruited as remission group, and 62 subjects without a history of depression served as the control group (HAMD17 ≤7).

Results: The mean RHI was 1.93, 2.34, and 2.19 in depression, control, and remission groups, respectively, showing a significant difference among the 3 groups (P=0.0004). In addition, a marked difference in RHI was found between depression and control groups (P=0.0003) and between depression and remission groups (P=0.0270). However, there was no significant difference between remission and control groups (P=0.3363).

Conclusions: There is a relationship between depression and endothelial dysfunction in outpatients from a general hospital in China. The improvement of depression is synchronous with the improvement of endothelial function.

No MeSH data available.


Related in: MedlinePlus

RHI of patients in the 3 groups.
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f1-medscimonit-21-1812: RHI of patients in the 3 groups.

Mentions: In terms of distribution balance of all covariates, a general linear model was used to compare RHI among the 3 groups without adjustments. The mean RHI was 1.93, 2.34, and 2.19 in the depression, control, and remission groups, respectively (Figure 1). The difference of RHI among the 3 groups was statistically significant (P=0.0004). Compared with the controls (2.337±0.697), RHI was significantly lower in the depression group (1.931±0.535; P=0.0003). RHI in the remission group (2.194±0.426) was markedly higher than in the depression group (P=0.027). However, there was no significant difference between remission and control groups (P=0.3363).


Relationships between Depressive Symptoms and Endothelial Function Among Outpatients of a General Hospital in China.

Shi H, Feng G, Wang Z, Zhou C, Zhong G, Hu Y, Wang G - Med. Sci. Monit. (2015)

RHI of patients in the 3 groups.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4492485&req=5

f1-medscimonit-21-1812: RHI of patients in the 3 groups.
Mentions: In terms of distribution balance of all covariates, a general linear model was used to compare RHI among the 3 groups without adjustments. The mean RHI was 1.93, 2.34, and 2.19 in the depression, control, and remission groups, respectively (Figure 1). The difference of RHI among the 3 groups was statistically significant (P=0.0004). Compared with the controls (2.337±0.697), RHI was significantly lower in the depression group (1.931±0.535; P=0.0003). RHI in the remission group (2.194±0.426) was markedly higher than in the depression group (P=0.027). However, there was no significant difference between remission and control groups (P=0.3363).

Bottom Line: The mean RHI was 1.93, 2.34, and 2.19 in depression, control, and remission groups, respectively, showing a significant difference among the 3 groups (P=0.0004).However, there was no significant difference between remission and control groups (P=0.3363).There is a relationship between depression and endothelial dysfunction in outpatients from a general hospital in China.

View Article: PubMed Central - PubMed

Affiliation: Depression Treatment Center, Beijing An Ding Hospital, Capital Medical University, Beijing, China (mainland).

ABSTRACT

Background: This study aimed to investigate the endothelial function by reactive hyperemia index (RHI) in patients with depression, subjects recovering from depression, and subjects without a history of depression.

Material and methods: Outpatients were recruited from a general hospital in China; 62 patients diagnosed with depression and the 17-item Hamilton Rating Scale for Depression (HAMD17) total scores ≥17 were enrolled as the depression group, 62 patients with a history of depression, discontinuation of antidepressants therapy at least 3 months ago, and HAMD17 ≤7 were recruited as remission group, and 62 subjects without a history of depression served as the control group (HAMD17 ≤7).

Results: The mean RHI was 1.93, 2.34, and 2.19 in depression, control, and remission groups, respectively, showing a significant difference among the 3 groups (P=0.0004). In addition, a marked difference in RHI was found between depression and control groups (P=0.0003) and between depression and remission groups (P=0.0270). However, there was no significant difference between remission and control groups (P=0.3363).

Conclusions: There is a relationship between depression and endothelial dysfunction in outpatients from a general hospital in China. The improvement of depression is synchronous with the improvement of endothelial function.

No MeSH data available.


Related in: MedlinePlus