Limits...
Elevated Serum Levels of NSE and S-100β Correlate with Increased Risk of Acute Cerebral Infarction in Asian Populations.

Li K, Jia J, Wang Z, Zhang S - Med. Sci. Monit. (2015)

Bottom Line: The results of the meta-analysis showed that serum levels of NSE and S-100β in ACI patients were significantly higher than the control group.In Caucasian population, the serum levels of NSE in case group was significantly higher than the control group, but no significant differences in serum levels of S-100β were observed between ACI patients and the control group.Based on our results, we conclude that serum levels of NSE and S-100β strongly correlate with ACI in Asian population, and may be important clinical markers for diagnosis and treatment of ACI.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China (mainland).

ABSTRACT

Background: We investigated the clinical value of serum levels of neuron-specific enolase (NSE) and human soluble protein-100β (S-100β) in acute cerebral infarction (ACI) patients.

Material and methods: A literature search of electronic databases identified relevant case-control studies that examined the correlations between NSE and S-100β serum levels, and ACI. The retrieved studies were screened based on our strict inclusion and exclusion criteria, and high-quality studies were subsequently selected for meta-analysis. STATA software (Version 12.0, Stata Corporation, College Station, TX, USA) was utilized for statistical analysis.

Results: A total of 13 case-control studies, containing 911 ACI patients and 686 healthy controls, were enrolled in this meta-analysis. The results of the meta-analysis showed that serum levels of NSE and S-100β in ACI patients were significantly higher than the control group. Subgroup analysis based on ethnicity revealed that the serum levels of NSE and S-100β in ACI patients were significantly higher than the control group in Asian population. In Caucasian population, the serum levels of NSE in case group was significantly higher than the control group, but no significant differences in serum levels of S-100β were observed between ACI patients and the control group.

Conclusions: Based on our results, we conclude that serum levels of NSE and S-100β strongly correlate with ACI in Asian population, and may be important clinical markers for diagnosis and treatment of ACI.

No MeSH data available.


Related in: MedlinePlus

Forest plots of subgroup analyses by ethnicity and sample size on the differences in serum levels of NSE and S-100β between acute cerebral infarction patients and the healthy controls.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4492484&req=5

f2-medscimonit-21-1879: Forest plots of subgroup analyses by ethnicity and sample size on the differences in serum levels of NSE and S-100β between acute cerebral infarction patients and the healthy controls.

Mentions: A total of 13 studies reported serum levels of NSE in ACI patients. Heterogeneity test suggested that heterogeneity existed across studies (I2=95.3%, P<0.001), thus a random effects model was applied. The result of this meta-analysis revealed that serum levels of NSE were significantly higher in ACI patients compared to control group, and the difference was statistically significant (SMD=1.96, 95%CI=1.83~2.09, P<0.001) (Figure 1). Additionally, subgroup analysis based on ethnicity indicated that serum levels of NSE were markedly higher in ACI patients, compared to the control group, in both Asians and Caucasians (Asian: SMD=2.11, 95%CI=1.96~2.25, P<0.001; Caucasian: SMD=1.32, 95%CI=1.02~1.61, P<0.001). A subgroup analysis based on sample size showed that serum levels of NSE in ACI patients of both large sample size (n≥100) and small sample size (n<100) were notably higher than the control group (large sample size: SMD=2.01, 95%CI=1.86~2.17, P<0.001; small sample size: SMD=1.80, 95%CI=1.55~2.05, P<0.001) (Figure 2). Univariate meta-regression analysis suggested that publication year, country, ethnicity and sample size were not the main sources of heterogeneity or the critical factors in influencing the overall effect size (P>0.05) (Figure 3A). Multiple meta-regression analysis also indicated that year of publication, country, ethnicity, and sample size were not the sources of heterogeneity (Table 2).


Elevated Serum Levels of NSE and S-100β Correlate with Increased Risk of Acute Cerebral Infarction in Asian Populations.

Li K, Jia J, Wang Z, Zhang S - Med. Sci. Monit. (2015)

Forest plots of subgroup analyses by ethnicity and sample size on the differences in serum levels of NSE and S-100β between acute cerebral infarction patients and the healthy controls.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4492484&req=5

f2-medscimonit-21-1879: Forest plots of subgroup analyses by ethnicity and sample size on the differences in serum levels of NSE and S-100β between acute cerebral infarction patients and the healthy controls.
Mentions: A total of 13 studies reported serum levels of NSE in ACI patients. Heterogeneity test suggested that heterogeneity existed across studies (I2=95.3%, P<0.001), thus a random effects model was applied. The result of this meta-analysis revealed that serum levels of NSE were significantly higher in ACI patients compared to control group, and the difference was statistically significant (SMD=1.96, 95%CI=1.83~2.09, P<0.001) (Figure 1). Additionally, subgroup analysis based on ethnicity indicated that serum levels of NSE were markedly higher in ACI patients, compared to the control group, in both Asians and Caucasians (Asian: SMD=2.11, 95%CI=1.96~2.25, P<0.001; Caucasian: SMD=1.32, 95%CI=1.02~1.61, P<0.001). A subgroup analysis based on sample size showed that serum levels of NSE in ACI patients of both large sample size (n≥100) and small sample size (n<100) were notably higher than the control group (large sample size: SMD=2.01, 95%CI=1.86~2.17, P<0.001; small sample size: SMD=1.80, 95%CI=1.55~2.05, P<0.001) (Figure 2). Univariate meta-regression analysis suggested that publication year, country, ethnicity and sample size were not the main sources of heterogeneity or the critical factors in influencing the overall effect size (P>0.05) (Figure 3A). Multiple meta-regression analysis also indicated that year of publication, country, ethnicity, and sample size were not the sources of heterogeneity (Table 2).

Bottom Line: The results of the meta-analysis showed that serum levels of NSE and S-100β in ACI patients were significantly higher than the control group.In Caucasian population, the serum levels of NSE in case group was significantly higher than the control group, but no significant differences in serum levels of S-100β were observed between ACI patients and the control group.Based on our results, we conclude that serum levels of NSE and S-100β strongly correlate with ACI in Asian population, and may be important clinical markers for diagnosis and treatment of ACI.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China (mainland).

ABSTRACT

Background: We investigated the clinical value of serum levels of neuron-specific enolase (NSE) and human soluble protein-100β (S-100β) in acute cerebral infarction (ACI) patients.

Material and methods: A literature search of electronic databases identified relevant case-control studies that examined the correlations between NSE and S-100β serum levels, and ACI. The retrieved studies were screened based on our strict inclusion and exclusion criteria, and high-quality studies were subsequently selected for meta-analysis. STATA software (Version 12.0, Stata Corporation, College Station, TX, USA) was utilized for statistical analysis.

Results: A total of 13 case-control studies, containing 911 ACI patients and 686 healthy controls, were enrolled in this meta-analysis. The results of the meta-analysis showed that serum levels of NSE and S-100β in ACI patients were significantly higher than the control group. Subgroup analysis based on ethnicity revealed that the serum levels of NSE and S-100β in ACI patients were significantly higher than the control group in Asian population. In Caucasian population, the serum levels of NSE in case group was significantly higher than the control group, but no significant differences in serum levels of S-100β were observed between ACI patients and the control group.

Conclusions: Based on our results, we conclude that serum levels of NSE and S-100β strongly correlate with ACI in Asian population, and may be important clinical markers for diagnosis and treatment of ACI.

No MeSH data available.


Related in: MedlinePlus