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Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report.

Lubana SS, Bashir T, Tuli SS, Kemeny MM, Heimann DM - Am J Case Rep (2015)

Bottom Line: The mass was fully resected with left below-knee amputation.A follow-up CT showed a new right breast nodule along with metastases to lung and bones.The results of the core needle biopsies of the right breast masses seen on mammogram were morphologically identical to extraskeletal myxoid chondrosarcoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Queens, NY, USA.

ABSTRACT

Background: Extraskeletal myxoid chondrosarcoma is a unique and distinct clinicopathological entity in terms of its origin, morphology, and biologic behavior. Despite being a slow-growing tumor, it has a high rate of local recurrences and history of metastases to uncommon sites like the mandible, liver, retroperitoneum, right ventricle, pancreas, and central nervous system. Here, we report a very unique case of extraskeletal myxoid chondrosarcoma that metastasized to the breast, which itself is a very rare site for metastases.

Case report: A 58-year-old woman presented with a large, firm, and tender soft-tissue mass (6.0×7.0 cm) underneath the sole of the left foot. A computerized tomography (CT) scan showed a heterogeneous lobulated mass in the plantar aspect of the forefoot, measuring 8.6×8.0×7.1 cm. Punch biopsies revealed histology consistent with extraskeletal myxoid chondrosarcoma. Metastatic work-up was negative. The mass was fully resected with left below-knee amputation. The histology of the resected mass was consistent with extraskeletal myxoid chondrosarcoma. A follow-up CT showed a new right breast nodule along with metastases to lung and bones. The results of the core needle biopsies of the right breast masses seen on mammogram were morphologically identical to extraskeletal myxoid chondrosarcoma.

Conclusions: Although rare, metastases to the breast should be considered in the differential diagnosis of a breast mass. A close long-term follow-up is needed due to the unpredictable behavior of extraskeletal myxoid chondrosarcoma and the high frequency of local recurrences, metastases, and death due to disease.

No MeSH data available.


Related in: MedlinePlus

(A – 100×, B – 400×): Histology of the breast metastatic lesion showing an infiltrating poorly differentiated mammary carcinoma with mucinous and myxochondroid features.
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f12-amjcaserep-16-406: (A – 100×, B – 400×): Histology of the breast metastatic lesion showing an infiltrating poorly differentiated mammary carcinoma with mucinous and myxochondroid features.

Mentions: The results of the core needle biopsies of masses in the right breast showed an infiltrating, poorly differentiated, mammary carcinoma with mucinous and myxochondroid features, which were morphologically identical to EMC (Figure 12A, 12B). CA 27.29 was normal at 24.4 Units/ml (0.0–37.7 Units/ml). The case was presented to the tumor board. Due to the poor prognosis, treatment options were to seek a second opinion for clinical trial at Memorial Sloan Kettering Cancer Center versus palliative chemotherapy with Ifosfamide/Adriamycin. The patient refused chemotherapy and is currently awaiting a second opinion.


Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report.

Lubana SS, Bashir T, Tuli SS, Kemeny MM, Heimann DM - Am J Case Rep (2015)

(A – 100×, B – 400×): Histology of the breast metastatic lesion showing an infiltrating poorly differentiated mammary carcinoma with mucinous and myxochondroid features.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4492482&req=5

f12-amjcaserep-16-406: (A – 100×, B – 400×): Histology of the breast metastatic lesion showing an infiltrating poorly differentiated mammary carcinoma with mucinous and myxochondroid features.
Mentions: The results of the core needle biopsies of masses in the right breast showed an infiltrating, poorly differentiated, mammary carcinoma with mucinous and myxochondroid features, which were morphologically identical to EMC (Figure 12A, 12B). CA 27.29 was normal at 24.4 Units/ml (0.0–37.7 Units/ml). The case was presented to the tumor board. Due to the poor prognosis, treatment options were to seek a second opinion for clinical trial at Memorial Sloan Kettering Cancer Center versus palliative chemotherapy with Ifosfamide/Adriamycin. The patient refused chemotherapy and is currently awaiting a second opinion.

Bottom Line: The mass was fully resected with left below-knee amputation.A follow-up CT showed a new right breast nodule along with metastases to lung and bones.The results of the core needle biopsies of the right breast masses seen on mammogram were morphologically identical to extraskeletal myxoid chondrosarcoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Queens, NY, USA.

ABSTRACT

Background: Extraskeletal myxoid chondrosarcoma is a unique and distinct clinicopathological entity in terms of its origin, morphology, and biologic behavior. Despite being a slow-growing tumor, it has a high rate of local recurrences and history of metastases to uncommon sites like the mandible, liver, retroperitoneum, right ventricle, pancreas, and central nervous system. Here, we report a very unique case of extraskeletal myxoid chondrosarcoma that metastasized to the breast, which itself is a very rare site for metastases.

Case report: A 58-year-old woman presented with a large, firm, and tender soft-tissue mass (6.0×7.0 cm) underneath the sole of the left foot. A computerized tomography (CT) scan showed a heterogeneous lobulated mass in the plantar aspect of the forefoot, measuring 8.6×8.0×7.1 cm. Punch biopsies revealed histology consistent with extraskeletal myxoid chondrosarcoma. Metastatic work-up was negative. The mass was fully resected with left below-knee amputation. The histology of the resected mass was consistent with extraskeletal myxoid chondrosarcoma. A follow-up CT showed a new right breast nodule along with metastases to lung and bones. The results of the core needle biopsies of the right breast masses seen on mammogram were morphologically identical to extraskeletal myxoid chondrosarcoma.

Conclusions: Although rare, metastases to the breast should be considered in the differential diagnosis of a breast mass. A close long-term follow-up is needed due to the unpredictable behavior of extraskeletal myxoid chondrosarcoma and the high frequency of local recurrences, metastases, and death due to disease.

No MeSH data available.


Related in: MedlinePlus