Limits...
Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report.

Lubana SS, Bashir T, Tuli SS, Kemeny MM, Heimann DM - Am J Case Rep (2015)

Bottom Line: The mass was fully resected with left below-knee amputation.A follow-up CT showed a new right breast nodule along with metastases to lung and bones.The results of the core needle biopsies of the right breast masses seen on mammogram were morphologically identical to extraskeletal myxoid chondrosarcoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Queens, NY, USA.

ABSTRACT

Background: Extraskeletal myxoid chondrosarcoma is a unique and distinct clinicopathological entity in terms of its origin, morphology, and biologic behavior. Despite being a slow-growing tumor, it has a high rate of local recurrences and history of metastases to uncommon sites like the mandible, liver, retroperitoneum, right ventricle, pancreas, and central nervous system. Here, we report a very unique case of extraskeletal myxoid chondrosarcoma that metastasized to the breast, which itself is a very rare site for metastases.

Case report: A 58-year-old woman presented with a large, firm, and tender soft-tissue mass (6.0×7.0 cm) underneath the sole of the left foot. A computerized tomography (CT) scan showed a heterogeneous lobulated mass in the plantar aspect of the forefoot, measuring 8.6×8.0×7.1 cm. Punch biopsies revealed histology consistent with extraskeletal myxoid chondrosarcoma. Metastatic work-up was negative. The mass was fully resected with left below-knee amputation. The histology of the resected mass was consistent with extraskeletal myxoid chondrosarcoma. A follow-up CT showed a new right breast nodule along with metastases to lung and bones. The results of the core needle biopsies of the right breast masses seen on mammogram were morphologically identical to extraskeletal myxoid chondrosarcoma.

Conclusions: Although rare, metastases to the breast should be considered in the differential diagnosis of a breast mass. A close long-term follow-up is needed due to the unpredictable behavior of extraskeletal myxoid chondrosarcoma and the high frequency of local recurrences, metastases, and death due to disease.

No MeSH data available.


Related in: MedlinePlus

Chest CT (A) demonstrates a small subcutaneous nodule overlying the right scapula that on follow up (B) has increased in size.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4492482&req=5

f6-amjcaserep-16-406: Chest CT (A) demonstrates a small subcutaneous nodule overlying the right scapula that on follow up (B) has increased in size.

Mentions: A CT scan of the chest 2 months after the surgery showed a 0.8-cm nodule in the subcutaneous tissues posterior to the right scapula suspicious for metastases (Figure 6A). The patient went back to Jamaica and returned after 6 months. A follow-up CT scan showed a new pulmonary nodule in the right lower lobe measuring 0.4 cm and new lucencies involving T7 and T12 vertebral bodies suspicious for metastases (Figure 7A, 7B). A new nodule in the right breast measuring 1.3×1.4 cm was also reported (Figure 8A, 8B). There was an interval increase in the size of the soft-tissue nodule in the subcutaneous fat posterior to the right scapula, measuring 1.6×1.1 cm (Figure 6B).


Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report.

Lubana SS, Bashir T, Tuli SS, Kemeny MM, Heimann DM - Am J Case Rep (2015)

Chest CT (A) demonstrates a small subcutaneous nodule overlying the right scapula that on follow up (B) has increased in size.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4492482&req=5

f6-amjcaserep-16-406: Chest CT (A) demonstrates a small subcutaneous nodule overlying the right scapula that on follow up (B) has increased in size.
Mentions: A CT scan of the chest 2 months after the surgery showed a 0.8-cm nodule in the subcutaneous tissues posterior to the right scapula suspicious for metastases (Figure 6A). The patient went back to Jamaica and returned after 6 months. A follow-up CT scan showed a new pulmonary nodule in the right lower lobe measuring 0.4 cm and new lucencies involving T7 and T12 vertebral bodies suspicious for metastases (Figure 7A, 7B). A new nodule in the right breast measuring 1.3×1.4 cm was also reported (Figure 8A, 8B). There was an interval increase in the size of the soft-tissue nodule in the subcutaneous fat posterior to the right scapula, measuring 1.6×1.1 cm (Figure 6B).

Bottom Line: The mass was fully resected with left below-knee amputation.A follow-up CT showed a new right breast nodule along with metastases to lung and bones.The results of the core needle biopsies of the right breast masses seen on mammogram were morphologically identical to extraskeletal myxoid chondrosarcoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Queens, NY, USA.

ABSTRACT

Background: Extraskeletal myxoid chondrosarcoma is a unique and distinct clinicopathological entity in terms of its origin, morphology, and biologic behavior. Despite being a slow-growing tumor, it has a high rate of local recurrences and history of metastases to uncommon sites like the mandible, liver, retroperitoneum, right ventricle, pancreas, and central nervous system. Here, we report a very unique case of extraskeletal myxoid chondrosarcoma that metastasized to the breast, which itself is a very rare site for metastases.

Case report: A 58-year-old woman presented with a large, firm, and tender soft-tissue mass (6.0×7.0 cm) underneath the sole of the left foot. A computerized tomography (CT) scan showed a heterogeneous lobulated mass in the plantar aspect of the forefoot, measuring 8.6×8.0×7.1 cm. Punch biopsies revealed histology consistent with extraskeletal myxoid chondrosarcoma. Metastatic work-up was negative. The mass was fully resected with left below-knee amputation. The histology of the resected mass was consistent with extraskeletal myxoid chondrosarcoma. A follow-up CT showed a new right breast nodule along with metastases to lung and bones. The results of the core needle biopsies of the right breast masses seen on mammogram were morphologically identical to extraskeletal myxoid chondrosarcoma.

Conclusions: Although rare, metastases to the breast should be considered in the differential diagnosis of a breast mass. A close long-term follow-up is needed due to the unpredictable behavior of extraskeletal myxoid chondrosarcoma and the high frequency of local recurrences, metastases, and death due to disease.

No MeSH data available.


Related in: MedlinePlus