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Anticancer Effect of Lycopene in Gastric Carcinogenesis.

Kim MJ, Kim H - J Cancer Prev (2015)

Bottom Line: Lycopene, one of the naturally occurring carotenoids, has unique structural and chemical features that contributes to a potent antioxidant activity.It shows a potential anticancer activity and reduces gastric cancer incidence.This review will summarize anticancer effect and mechanism of lycopene on gastric carcinogenesis based on the recent experimental and clinical studies.

View Article: PubMed Central - PubMed

Affiliation: Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.

ABSTRACT
Gastric cancer ranks as the most common cancer and the second leading cause of cancer-related death in the world. Risk factors of gastric carcinogenesis include oxidative stress, DNA damage, Helicobacter pylori infection, bad eating habits, and smoking. Since oxidative stress is related to DNA damage, smoking, and H. pylori infection, scavenging of reactive oxygen species may be beneficial for prevention of gastric carcinogenesis. Lycopene, one of the naturally occurring carotenoids, has unique structural and chemical features that contributes to a potent antioxidant activity. It shows a potential anticancer activity and reduces gastric cancer incidence. This review will summarize anticancer effect and mechanism of lycopene on gastric carcinogenesis based on the recent experimental and clinical studies.

No MeSH data available.


Related in: MedlinePlus

A schematic overview of the protective effect of lycopene against gastric carcinogenesis. Smoking, inflammation, and Helicobacter pylori infection induce oxidative stress which leads to DNA damage, ERK activation and p53 overexpression, decreased activities of antioxidant enzymes (GSH, GST, GPx) as well as impaired immune function. Low activities of antioxidant enzymes may decrease immune function of gastric mucosa. ERK activation and p53 overexpression induce cell cycle disturbances and inhibition of apoptosis as well as hyper-proliferation, resulting in gastric carcinogenesis. Poor diet, bad eating habits, and family history may be risk factors to induce DNA damage and cell cycle disturbances by affecting intrinsic factors or producing reactive oxygen species or oncogenic factors. Lycopene scavenges reactive oxygen species and stimulates activities of antioxidant enzymes, which protects gastric mucosa against oxidative stress-induced ERK activation, p53 induction, cell cycle disturbances, and impaired immune function. Therefore, lycopene may prevent oxidative stress-mediated gastric carcinogenesis. ERK, extracellular signal-regulated kinase; GSH, glutathione; GST, glutathione-S-transferase; GPx, glutathione peroxidase.
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f1-jcp-20-92: A schematic overview of the protective effect of lycopene against gastric carcinogenesis. Smoking, inflammation, and Helicobacter pylori infection induce oxidative stress which leads to DNA damage, ERK activation and p53 overexpression, decreased activities of antioxidant enzymes (GSH, GST, GPx) as well as impaired immune function. Low activities of antioxidant enzymes may decrease immune function of gastric mucosa. ERK activation and p53 overexpression induce cell cycle disturbances and inhibition of apoptosis as well as hyper-proliferation, resulting in gastric carcinogenesis. Poor diet, bad eating habits, and family history may be risk factors to induce DNA damage and cell cycle disturbances by affecting intrinsic factors or producing reactive oxygen species or oncogenic factors. Lycopene scavenges reactive oxygen species and stimulates activities of antioxidant enzymes, which protects gastric mucosa against oxidative stress-induced ERK activation, p53 induction, cell cycle disturbances, and impaired immune function. Therefore, lycopene may prevent oxidative stress-mediated gastric carcinogenesis. ERK, extracellular signal-regulated kinase; GSH, glutathione; GST, glutathione-S-transferase; GPx, glutathione peroxidase.

Mentions: Based on the studies, we propose a mechanism by which lycopene exerts protective effect against oxidative stress-mediated gastric carcinogenesis (Fig. 1). Smoking, inflammation, and H. pylori infection induce oxidative stress which leads to DNA damage, ERK activation and p53 overexpression, decreased activities of antioxidant enzymes (GSH, GST, GPx) as well as impaired immune function. Low activities of antioxidant enzymes may decrease immune function of gastric mucosa. ERK activation and p53 overexpression induce cell cycle disturbances and inhibition of apoptosis as well as hyper-proliferation, resulting in gastric carcinogenesis. Poor diet, bad eating habits, and family history may be risk factors to induce DNA damage and cell cycle disturbances by affecting intrinsic factors or producing ROS or oncogenic factors. Lycopene scavenges ROS and stimulates activities of antioxidant enzymes, which protects gastric mucosa against oxidative stress-induced ERK activation, p53 induction, cell cycle disturbances, and impaired immune function. Therefore, supplementation of lycopene or consumption of lycopene-containing fruits and vegetables may prevent oxidative stress-mediated gastric carcinogenesis.


Anticancer Effect of Lycopene in Gastric Carcinogenesis.

Kim MJ, Kim H - J Cancer Prev (2015)

A schematic overview of the protective effect of lycopene against gastric carcinogenesis. Smoking, inflammation, and Helicobacter pylori infection induce oxidative stress which leads to DNA damage, ERK activation and p53 overexpression, decreased activities of antioxidant enzymes (GSH, GST, GPx) as well as impaired immune function. Low activities of antioxidant enzymes may decrease immune function of gastric mucosa. ERK activation and p53 overexpression induce cell cycle disturbances and inhibition of apoptosis as well as hyper-proliferation, resulting in gastric carcinogenesis. Poor diet, bad eating habits, and family history may be risk factors to induce DNA damage and cell cycle disturbances by affecting intrinsic factors or producing reactive oxygen species or oncogenic factors. Lycopene scavenges reactive oxygen species and stimulates activities of antioxidant enzymes, which protects gastric mucosa against oxidative stress-induced ERK activation, p53 induction, cell cycle disturbances, and impaired immune function. Therefore, lycopene may prevent oxidative stress-mediated gastric carcinogenesis. ERK, extracellular signal-regulated kinase; GSH, glutathione; GST, glutathione-S-transferase; GPx, glutathione peroxidase.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4492364&req=5

f1-jcp-20-92: A schematic overview of the protective effect of lycopene against gastric carcinogenesis. Smoking, inflammation, and Helicobacter pylori infection induce oxidative stress which leads to DNA damage, ERK activation and p53 overexpression, decreased activities of antioxidant enzymes (GSH, GST, GPx) as well as impaired immune function. Low activities of antioxidant enzymes may decrease immune function of gastric mucosa. ERK activation and p53 overexpression induce cell cycle disturbances and inhibition of apoptosis as well as hyper-proliferation, resulting in gastric carcinogenesis. Poor diet, bad eating habits, and family history may be risk factors to induce DNA damage and cell cycle disturbances by affecting intrinsic factors or producing reactive oxygen species or oncogenic factors. Lycopene scavenges reactive oxygen species and stimulates activities of antioxidant enzymes, which protects gastric mucosa against oxidative stress-induced ERK activation, p53 induction, cell cycle disturbances, and impaired immune function. Therefore, lycopene may prevent oxidative stress-mediated gastric carcinogenesis. ERK, extracellular signal-regulated kinase; GSH, glutathione; GST, glutathione-S-transferase; GPx, glutathione peroxidase.
Mentions: Based on the studies, we propose a mechanism by which lycopene exerts protective effect against oxidative stress-mediated gastric carcinogenesis (Fig. 1). Smoking, inflammation, and H. pylori infection induce oxidative stress which leads to DNA damage, ERK activation and p53 overexpression, decreased activities of antioxidant enzymes (GSH, GST, GPx) as well as impaired immune function. Low activities of antioxidant enzymes may decrease immune function of gastric mucosa. ERK activation and p53 overexpression induce cell cycle disturbances and inhibition of apoptosis as well as hyper-proliferation, resulting in gastric carcinogenesis. Poor diet, bad eating habits, and family history may be risk factors to induce DNA damage and cell cycle disturbances by affecting intrinsic factors or producing ROS or oncogenic factors. Lycopene scavenges ROS and stimulates activities of antioxidant enzymes, which protects gastric mucosa against oxidative stress-induced ERK activation, p53 induction, cell cycle disturbances, and impaired immune function. Therefore, supplementation of lycopene or consumption of lycopene-containing fruits and vegetables may prevent oxidative stress-mediated gastric carcinogenesis.

Bottom Line: Lycopene, one of the naturally occurring carotenoids, has unique structural and chemical features that contributes to a potent antioxidant activity.It shows a potential anticancer activity and reduces gastric cancer incidence.This review will summarize anticancer effect and mechanism of lycopene on gastric carcinogenesis based on the recent experimental and clinical studies.

View Article: PubMed Central - PubMed

Affiliation: Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.

ABSTRACT
Gastric cancer ranks as the most common cancer and the second leading cause of cancer-related death in the world. Risk factors of gastric carcinogenesis include oxidative stress, DNA damage, Helicobacter pylori infection, bad eating habits, and smoking. Since oxidative stress is related to DNA damage, smoking, and H. pylori infection, scavenging of reactive oxygen species may be beneficial for prevention of gastric carcinogenesis. Lycopene, one of the naturally occurring carotenoids, has unique structural and chemical features that contributes to a potent antioxidant activity. It shows a potential anticancer activity and reduces gastric cancer incidence. This review will summarize anticancer effect and mechanism of lycopene on gastric carcinogenesis based on the recent experimental and clinical studies.

No MeSH data available.


Related in: MedlinePlus