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Influence of metabolic and other clinicopathologic factors on the prognosis of patients with hepatocellular carcinoma undergoing hepatic resection.

Choi KS, Kim DS, Jung SW, Yu YD, Suh SO - Korean J Hepatobiliary Pancreat Surg (2014)

Bottom Line: In Korea, the hepatitis B virus prevalence rate is higher than in other countries.Two operative mortality cases and two short-term follow up cases were excluded.Further study is required to clarify the influence of metabolic and other clinicopathologic factors on the prognosis of HCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Korea University College of Medicine, Seoul, Korea.

ABSTRACT

Backgrounds/aims: The prognosis of hepatic resection for hepatocellular carcinoma (HCC) in patients with cirrhosis is worse than in those without cirrhosis. In Korea, the hepatitis B virus prevalence rate is higher than in other countries. Therefore, we investigated patients' clinicopathologic and metabolic factors that affect the postoperative outcomes of hepatic resection for HCC in our hospital in Korea.

Methods: From August 2000 to December 2012, 171 HCC patients underwent hepatic resections at our institution. Two operative mortality cases and two short-term follow up cases were excluded. Data was collected from a retrospective chart review. There were 133 males (79.6%) and 34 females (20.3%), with a mean age of 58.2±10.2 years (range, 22-81 years), and the relationship between clinicopathologic and metabolic factors and the prognosis of patients with HCC undergoing hepatic resection were evaluated by univariate and multivariate analysis.

Results: Hypertension, major surgery, perioperative transfusion, resection with radiofrequency ablation (RFA) or cryoablation, and resection margin were risk factors for overall survival, and hypertension, albumin, resection with RFA or cryoablation, perioperative transfusion, and tumor size were risk factors for disease-free survival.

Conclusions: We found that hypertension, perioperative transfusion, and resection with RFA or cryoablation were risk factors for both disease-free and overall survival after hepatic resection in HCC patients. Further study is required to clarify the influence of metabolic and other clinicopathologic factors on the prognosis of HCC.

No MeSH data available.


Related in: MedlinePlus

Disease-free survival curve of 157 patients (A) and overall survival curve of all patients (B).
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Figure 1: Disease-free survival curve of 157 patients (A) and overall survival curve of all patients (B).

Mentions: The mean disease-free survival period was 23.2±27.7 months, and the mean overall survival period was 34.8±33.1 months. Nine of the 167 patients were margin-positive and one did not have a reported margin status. Recurrence was noted in 73 patients among the 157 during follow-up, and 56 patients among the 167 died. The 1-, 3-, and 5-year disease-free survival rates of the 157 patients were 70.0%, 56.6%, and 54.1%, respectively, and the respective overall survivalof the total patients were 91.6%, 79.0%, and 73.0%, respectively (Fig. 1).


Influence of metabolic and other clinicopathologic factors on the prognosis of patients with hepatocellular carcinoma undergoing hepatic resection.

Choi KS, Kim DS, Jung SW, Yu YD, Suh SO - Korean J Hepatobiliary Pancreat Surg (2014)

Disease-free survival curve of 157 patients (A) and overall survival curve of all patients (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4492353&req=5

Figure 1: Disease-free survival curve of 157 patients (A) and overall survival curve of all patients (B).
Mentions: The mean disease-free survival period was 23.2±27.7 months, and the mean overall survival period was 34.8±33.1 months. Nine of the 167 patients were margin-positive and one did not have a reported margin status. Recurrence was noted in 73 patients among the 157 during follow-up, and 56 patients among the 167 died. The 1-, 3-, and 5-year disease-free survival rates of the 157 patients were 70.0%, 56.6%, and 54.1%, respectively, and the respective overall survivalof the total patients were 91.6%, 79.0%, and 73.0%, respectively (Fig. 1).

Bottom Line: In Korea, the hepatitis B virus prevalence rate is higher than in other countries.Two operative mortality cases and two short-term follow up cases were excluded.Further study is required to clarify the influence of metabolic and other clinicopathologic factors on the prognosis of HCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Korea University College of Medicine, Seoul, Korea.

ABSTRACT

Backgrounds/aims: The prognosis of hepatic resection for hepatocellular carcinoma (HCC) in patients with cirrhosis is worse than in those without cirrhosis. In Korea, the hepatitis B virus prevalence rate is higher than in other countries. Therefore, we investigated patients' clinicopathologic and metabolic factors that affect the postoperative outcomes of hepatic resection for HCC in our hospital in Korea.

Methods: From August 2000 to December 2012, 171 HCC patients underwent hepatic resections at our institution. Two operative mortality cases and two short-term follow up cases were excluded. Data was collected from a retrospective chart review. There were 133 males (79.6%) and 34 females (20.3%), with a mean age of 58.2±10.2 years (range, 22-81 years), and the relationship between clinicopathologic and metabolic factors and the prognosis of patients with HCC undergoing hepatic resection were evaluated by univariate and multivariate analysis.

Results: Hypertension, major surgery, perioperative transfusion, resection with radiofrequency ablation (RFA) or cryoablation, and resection margin were risk factors for overall survival, and hypertension, albumin, resection with RFA or cryoablation, perioperative transfusion, and tumor size were risk factors for disease-free survival.

Conclusions: We found that hypertension, perioperative transfusion, and resection with RFA or cryoablation were risk factors for both disease-free and overall survival after hepatic resection in HCC patients. Further study is required to clarify the influence of metabolic and other clinicopathologic factors on the prognosis of HCC.

No MeSH data available.


Related in: MedlinePlus