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Surgical outcome and prognostic factors in patients with gallbladder carcinoma.

Hong EK, Kim KK, Lee JN, Lee WK, Chung M, Kim YS, Park YH - Korean J Hepatobiliary Pancreat Surg (2014)

Bottom Line: Gallbladder carcinoma is usually associated with an unfavorable prognosis, and the clinical outcome has not improved much.Multivariate analysis revealed that curative resection, preoperative CA19-9, T-stage, N-stage and differentiation of histology were independently significant prognostic factors.Radical resection improves survival for patients with localized gallbladder carcinoma and can help to access exact prognosis and treatments.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Gachon University Gil Medical Center, Incheon, Korea.

ABSTRACT

Backgrounds/aims: Gallbladder carcinoma is usually associated with an unfavorable prognosis, and the clinical outcome has not improved much. This study was conducted to evaluate outcomes with gallbladder carcinoma according to the type of surgery performed, and the prognostic factors for survival.

Methods: One hundred and six patients with gallbladder carcinoma, who underwent surgery for the purpose of curative resection between January 1999 and June 2012 were reviewed retrospectively.

Results: Out of 106 patients, curative resection was achieved in 75 (70.8%). The cumulative 1-, 2- and 5-year survival rates of the gallbladder carcinoma patients were 93.4%, 80.9% and 63.0%, respectively. Radical resections, including extended cholecystectomy, were more beneficial for long term survival of patients. The 5-year survival rate in patients who underwent curative resection (56.9%) was significantly higher than in those who underwent palliative resection (0%, p=0.000). Multivariate analysis revealed that curative resection, preoperative CA19-9, T-stage, N-stage and differentiation of histology were independently significant prognostic factors.

Conclusions: Curative resection and early detection of patients with gallbladder carcinoma were the most important factors for long term survival. Radical resection improves survival for patients with localized gallbladder carcinoma and can help to access exact prognosis and treatments.

No MeSH data available.


Related in: MedlinePlus

Cumulative survival curves according to 7th AJCC staging system.
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Figure 2: Cumulative survival curves according to 7th AJCC staging system.

Mentions: The median follow-up period for the patients was 10 months (range, 2-160 months). The 1-, 2-, 3-, and 5-year cumulative survival rates of 106 patients who received surgery and could be followed-up on were 93.4%, 80.9%, 73.0%, and 63.0%, respectively. The cumulative survival rate of all patients was 38.1% (Fig. 1) and the median survival period was 14 months. For the 5-year survival rate by cancer stage, stages I, II, and IIA were 93.3%, 56.7%, and 21.9%, respectively, and no long-term survivor was found in the patient group above stage IIIB (Table 3, Fig. 2). The 1-, 2- and 3-year survival rates of the patient group without residual tumor after the surgery (curative procedure) were 90.5%, 82.8%, and 56.9%, while the survival rates of patients who had residual tumor and palliative procedure were 61.3%, 32.3%, and 0%, indicating that the patient group that received curative surgery had significantly higher survival (p=0.0003) (Fig. 3).


Surgical outcome and prognostic factors in patients with gallbladder carcinoma.

Hong EK, Kim KK, Lee JN, Lee WK, Chung M, Kim YS, Park YH - Korean J Hepatobiliary Pancreat Surg (2014)

Cumulative survival curves according to 7th AJCC staging system.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4492352&req=5

Figure 2: Cumulative survival curves according to 7th AJCC staging system.
Mentions: The median follow-up period for the patients was 10 months (range, 2-160 months). The 1-, 2-, 3-, and 5-year cumulative survival rates of 106 patients who received surgery and could be followed-up on were 93.4%, 80.9%, 73.0%, and 63.0%, respectively. The cumulative survival rate of all patients was 38.1% (Fig. 1) and the median survival period was 14 months. For the 5-year survival rate by cancer stage, stages I, II, and IIA were 93.3%, 56.7%, and 21.9%, respectively, and no long-term survivor was found in the patient group above stage IIIB (Table 3, Fig. 2). The 1-, 2- and 3-year survival rates of the patient group without residual tumor after the surgery (curative procedure) were 90.5%, 82.8%, and 56.9%, while the survival rates of patients who had residual tumor and palliative procedure were 61.3%, 32.3%, and 0%, indicating that the patient group that received curative surgery had significantly higher survival (p=0.0003) (Fig. 3).

Bottom Line: Gallbladder carcinoma is usually associated with an unfavorable prognosis, and the clinical outcome has not improved much.Multivariate analysis revealed that curative resection, preoperative CA19-9, T-stage, N-stage and differentiation of histology were independently significant prognostic factors.Radical resection improves survival for patients with localized gallbladder carcinoma and can help to access exact prognosis and treatments.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Gachon University Gil Medical Center, Incheon, Korea.

ABSTRACT

Backgrounds/aims: Gallbladder carcinoma is usually associated with an unfavorable prognosis, and the clinical outcome has not improved much. This study was conducted to evaluate outcomes with gallbladder carcinoma according to the type of surgery performed, and the prognostic factors for survival.

Methods: One hundred and six patients with gallbladder carcinoma, who underwent surgery for the purpose of curative resection between January 1999 and June 2012 were reviewed retrospectively.

Results: Out of 106 patients, curative resection was achieved in 75 (70.8%). The cumulative 1-, 2- and 5-year survival rates of the gallbladder carcinoma patients were 93.4%, 80.9% and 63.0%, respectively. Radical resections, including extended cholecystectomy, were more beneficial for long term survival of patients. The 5-year survival rate in patients who underwent curative resection (56.9%) was significantly higher than in those who underwent palliative resection (0%, p=0.000). Multivariate analysis revealed that curative resection, preoperative CA19-9, T-stage, N-stage and differentiation of histology were independently significant prognostic factors.

Conclusions: Curative resection and early detection of patients with gallbladder carcinoma were the most important factors for long term survival. Radical resection improves survival for patients with localized gallbladder carcinoma and can help to access exact prognosis and treatments.

No MeSH data available.


Related in: MedlinePlus