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Comparative analysis of Laparoscopic versus open surgical radiofrequency ablation for malignant liver tumors.

Yun D, Kim S, Song I, Chun K - Korean J Hepatobiliary Pancreat Surg (2014)

Bottom Line: There were no statistically significant differences between the two groups in terms of recurrence rate (p=0.337) and overall survival (p=0.423).However, patients in the laparoscopic RFA group had significantly shorter hospital stay (14.1 vs. 5.9 days, p<0.05) and experienced fewer complications (Grade I: 62.5% vs. 26.3%, p=0.102).Laparoscopic RFA can be performed for malignant liver tumors with lower morbidity rates, less invasiveness and lower expense compared to open surgical approach.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Chungnam National University Hospital, Daejeon, Korea.

ABSTRACT

Backgrounds/aims: This study aims to evaluate the comparative effectiveness of two surgical approaches on the treatment outcomes of radiofrequency ablation (RFA) for malignant liver tumors.

Methods: Fifty-seven patients with malignant liver tumors, hepatocellular carcinoma, cholangiocarcinoma and liver metastases, who were candidates for RFA, underwent laparoscopic or open surgical treatments.

Results: The patients' characteristics were comparable in the two groups that received open (n=33, 57.9%) and laparoscopic (n=24, 42.1%) surgical treatments. There were no statistically significant differences between the two groups in terms of recurrence rate (p=0.337) and overall survival (p=0.423). However, patients in the laparoscopic RFA group had significantly shorter hospital stay (14.1 vs. 5.9 days, p<0.05) and experienced fewer complications (Grade I: 62.5% vs. 26.3%, p=0.102).

Conclusions: Laparoscopic RFA can be performed for malignant liver tumors with lower morbidity rates, less invasiveness and lower expense compared to open surgical approach.

No MeSH data available.


Related in: MedlinePlus

Comparison of recurrence rates after open and laparoscopic radiofrequency ablation for hepatocellular carcinoma (A) and liver metastasis from colorectal cancer (B).
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Figure 1: Comparison of recurrence rates after open and laparoscopic radiofrequency ablation for hepatocellular carcinoma (A) and liver metastasis from colorectal cancer (B).

Mentions: One patient with HCC (3.8%) showed incomplete ablation on the immediate follow-up computed tomography (CT) scan. None of the patients with HCC showed local tumor progression, but ten had a new lesion (4 for open and 4 for laparoscopic approaches). One of the patients with cholangiocarcinoma had local tumor progression after open surgical RFA but no new lesions. In metastasis cases, two (6.9%) and one (3.4%) patients who underwent open and laparoscopic RFA respectively had local tumor progression whereas ten (34.5%) and three (33.3%) had a new lesion (Tables 3, 4). The median disease-free survival time was 11 months for patients with HCC (range, 2-57 months) and 10 months for those with liver metastasis, especially from colorectal cancer (range, 2-54 months). The difference in local recurrence rates after intraoperative RFA was not statistically significant between the two groups according to the tumor pathology. The overall recurrence rate three-years after open and laparoscopic RFA was 73.3% and 61.4% for patients with HCC (p=0.370), respectively; the rate was 72.2% and 60% for patients with liver metastasis from colorectal cancer, respectively (p=0.354) (Fig. 1).


Comparative analysis of Laparoscopic versus open surgical radiofrequency ablation for malignant liver tumors.

Yun D, Kim S, Song I, Chun K - Korean J Hepatobiliary Pancreat Surg (2014)

Comparison of recurrence rates after open and laparoscopic radiofrequency ablation for hepatocellular carcinoma (A) and liver metastasis from colorectal cancer (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4492349&req=5

Figure 1: Comparison of recurrence rates after open and laparoscopic radiofrequency ablation for hepatocellular carcinoma (A) and liver metastasis from colorectal cancer (B).
Mentions: One patient with HCC (3.8%) showed incomplete ablation on the immediate follow-up computed tomography (CT) scan. None of the patients with HCC showed local tumor progression, but ten had a new lesion (4 for open and 4 for laparoscopic approaches). One of the patients with cholangiocarcinoma had local tumor progression after open surgical RFA but no new lesions. In metastasis cases, two (6.9%) and one (3.4%) patients who underwent open and laparoscopic RFA respectively had local tumor progression whereas ten (34.5%) and three (33.3%) had a new lesion (Tables 3, 4). The median disease-free survival time was 11 months for patients with HCC (range, 2-57 months) and 10 months for those with liver metastasis, especially from colorectal cancer (range, 2-54 months). The difference in local recurrence rates after intraoperative RFA was not statistically significant between the two groups according to the tumor pathology. The overall recurrence rate three-years after open and laparoscopic RFA was 73.3% and 61.4% for patients with HCC (p=0.370), respectively; the rate was 72.2% and 60% for patients with liver metastasis from colorectal cancer, respectively (p=0.354) (Fig. 1).

Bottom Line: There were no statistically significant differences between the two groups in terms of recurrence rate (p=0.337) and overall survival (p=0.423).However, patients in the laparoscopic RFA group had significantly shorter hospital stay (14.1 vs. 5.9 days, p<0.05) and experienced fewer complications (Grade I: 62.5% vs. 26.3%, p=0.102).Laparoscopic RFA can be performed for malignant liver tumors with lower morbidity rates, less invasiveness and lower expense compared to open surgical approach.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Chungnam National University Hospital, Daejeon, Korea.

ABSTRACT

Backgrounds/aims: This study aims to evaluate the comparative effectiveness of two surgical approaches on the treatment outcomes of radiofrequency ablation (RFA) for malignant liver tumors.

Methods: Fifty-seven patients with malignant liver tumors, hepatocellular carcinoma, cholangiocarcinoma and liver metastases, who were candidates for RFA, underwent laparoscopic or open surgical treatments.

Results: The patients' characteristics were comparable in the two groups that received open (n=33, 57.9%) and laparoscopic (n=24, 42.1%) surgical treatments. There were no statistically significant differences between the two groups in terms of recurrence rate (p=0.337) and overall survival (p=0.423). However, patients in the laparoscopic RFA group had significantly shorter hospital stay (14.1 vs. 5.9 days, p<0.05) and experienced fewer complications (Grade I: 62.5% vs. 26.3%, p=0.102).

Conclusions: Laparoscopic RFA can be performed for malignant liver tumors with lower morbidity rates, less invasiveness and lower expense compared to open surgical approach.

No MeSH data available.


Related in: MedlinePlus