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Extended distal pancreatectomy for advanced pancreatic neck cancer.

Park SY, Shin WY, Choe YM, Lee KY, Ahn SI - Korean J Hepatobiliary Pancreat Surg (2014)

Bottom Line: The results were compared with those after standard pancreatectomy.All three patients presented with jaundice, and the ratio of pancreatic duct to parenchymal thickness of the pancreatic body was greater than 0.5.Also, the procedure is technically feasible, and further refinement is necessary to improve patient survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Inha University School of Medicine, Incheon, Korea.

ABSTRACT

Backgrounds/aims: We investigated the clinical application of extended distal pancreatectomy in patients with pancreatic neck cancer accompanied by distal pancreatic atrophy. In this study, we have emphasized on the technical aspects of using the linear stapling device for a bulky target organ.

Methods: From March 2010 to September 2013, 46 patients with pancreatic adenocarcinoma, who underwent pancreatic resection with radical intent at our institute, were reviewed retrospectively. Among them, three patients (6.5%) underwent extended distal pancreatectomy. A linear stapling device and vise-grip locking pliers were used for en bloc resection of the distal pancreas, first duodenal portion, and distal common bile duct. The results were compared with those after standard pancreatectomy.

Results: All three patients presented with jaundice, and the ratio of pancreatic duct to parenchymal thickness of the pancreatic body was greater than 0.5. Grade A pancreatic fistula developed in all of the cases, but none of these fistulae were lethal. Pathological staging was T3N1M0 in all of the patients. The postoperative daily serum glucose fluctuations and insulin requirements were comparable to those in patients who received pancreaticoduodenectomy or distal pancreatectomy. At the last follow-up, two patients were alive with liver metastasis at 4 and 10 months postoperatively, respectively, and one patient died of liver metastasis at 5 months postoperatively.

Conclusions: While the prognosis of advanced pancreatic neck adenocarcinoma is still dismal, extended distal pancreatectomy is a valid treatment option, especially when there is atrophy of the distal pancreas. Also, the procedure is technically feasible, and further refinement is necessary to improve patient survival.

No MeSH data available.


Related in: MedlinePlus

Follow-up computed tomography scan of the patient presented in Fig. 1 at 4 months after surgery. (A) The remnant pancreas is well-preserved (arrow), with intact portal flow (arrow head), although the patient developed multiple liver metastases (double arrow). (B) Coronal view of the uncinate process of the preserved pancreas (arrow) with the stapler line (arrow head).
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Figure 4: Follow-up computed tomography scan of the patient presented in Fig. 1 at 4 months after surgery. (A) The remnant pancreas is well-preserved (arrow), with intact portal flow (arrow head), although the patient developed multiple liver metastases (double arrow). (B) Coronal view of the uncinate process of the preserved pancreas (arrow) with the stapler line (arrow head).

Mentions: The main outcomes of this study included postoperative pancreatic fistula (according to the ISGPF definition);4 endocrine insufficiency, as indicated by daily serum glucose fluctuation (ΔG) and insulin requirements;5 and exocrine insufficiency, as indicated by steatorrhea.6 The integrity of the uncinate process of the remnant pancreas was also assessed on follow-up computed tomography scans (Fig. 4).


Extended distal pancreatectomy for advanced pancreatic neck cancer.

Park SY, Shin WY, Choe YM, Lee KY, Ahn SI - Korean J Hepatobiliary Pancreat Surg (2014)

Follow-up computed tomography scan of the patient presented in Fig. 1 at 4 months after surgery. (A) The remnant pancreas is well-preserved (arrow), with intact portal flow (arrow head), although the patient developed multiple liver metastases (double arrow). (B) Coronal view of the uncinate process of the preserved pancreas (arrow) with the stapler line (arrow head).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492328&req=5

Figure 4: Follow-up computed tomography scan of the patient presented in Fig. 1 at 4 months after surgery. (A) The remnant pancreas is well-preserved (arrow), with intact portal flow (arrow head), although the patient developed multiple liver metastases (double arrow). (B) Coronal view of the uncinate process of the preserved pancreas (arrow) with the stapler line (arrow head).
Mentions: The main outcomes of this study included postoperative pancreatic fistula (according to the ISGPF definition);4 endocrine insufficiency, as indicated by daily serum glucose fluctuation (ΔG) and insulin requirements;5 and exocrine insufficiency, as indicated by steatorrhea.6 The integrity of the uncinate process of the remnant pancreas was also assessed on follow-up computed tomography scans (Fig. 4).

Bottom Line: The results were compared with those after standard pancreatectomy.All three patients presented with jaundice, and the ratio of pancreatic duct to parenchymal thickness of the pancreatic body was greater than 0.5.Also, the procedure is technically feasible, and further refinement is necessary to improve patient survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Inha University School of Medicine, Incheon, Korea.

ABSTRACT

Backgrounds/aims: We investigated the clinical application of extended distal pancreatectomy in patients with pancreatic neck cancer accompanied by distal pancreatic atrophy. In this study, we have emphasized on the technical aspects of using the linear stapling device for a bulky target organ.

Methods: From March 2010 to September 2013, 46 patients with pancreatic adenocarcinoma, who underwent pancreatic resection with radical intent at our institute, were reviewed retrospectively. Among them, three patients (6.5%) underwent extended distal pancreatectomy. A linear stapling device and vise-grip locking pliers were used for en bloc resection of the distal pancreas, first duodenal portion, and distal common bile duct. The results were compared with those after standard pancreatectomy.

Results: All three patients presented with jaundice, and the ratio of pancreatic duct to parenchymal thickness of the pancreatic body was greater than 0.5. Grade A pancreatic fistula developed in all of the cases, but none of these fistulae were lethal. Pathological staging was T3N1M0 in all of the patients. The postoperative daily serum glucose fluctuations and insulin requirements were comparable to those in patients who received pancreaticoduodenectomy or distal pancreatectomy. At the last follow-up, two patients were alive with liver metastasis at 4 and 10 months postoperatively, respectively, and one patient died of liver metastasis at 5 months postoperatively.

Conclusions: While the prognosis of advanced pancreatic neck adenocarcinoma is still dismal, extended distal pancreatectomy is a valid treatment option, especially when there is atrophy of the distal pancreas. Also, the procedure is technically feasible, and further refinement is necessary to improve patient survival.

No MeSH data available.


Related in: MedlinePlus