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Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes.

Rochester JR, Bolden AL - Environ. Health Perspect. (2015)

Bottom Line: Further, we compared the hormonal potency of BPS and BPF to that of BPA.The majority of these studies examined the hormonal activities of BPS and BPF and found their potency to be in the same order of magnitude and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro and in vivo.Based on the current literature, BPS and BPF are as hormonally active as BPA, and they have endocrine-disrupting effects.

View Article: PubMed Central - PubMed

Affiliation: The Endocrine Disruption Exchange (TEDX), Paonia, Colorado, USA.

ABSTRACT

Background: Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled "BPA-free." Some of the chemical replacements, however, are also bisphenols and may have similar physiological effects in organisms. Bisphenol S (BPS) and bisphenol F (BPF) are two such BPA substitutes.

Objectives: This review was carried out to evaluate the physiological effects and endocrine activities of the BPA substitutes BPS and BPF. Further, we compared the hormonal potency of BPS and BPF to that of BPA.

Methods: We conducted a systematic review based on the Office of Health Assessment and Translation (OHAT) protocol.

Results: We identified the body of literature to date, consisting of 32 studies (25 in vitro only, and 7 in vivo). The majority of these studies examined the hormonal activities of BPS and BPF and found their potency to be in the same order of magnitude and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro and in vivo. BPS also has potencies similar to that of estradiol in membrane-mediated pathways, which are important for cellular actions such as proliferation, differentiation, and death. BPS and BPF also showed other effects in vitro and in vivo, such as altered organ weights, reproductive end points, and enzyme expression.

Conclusions: Based on the current literature, BPS and BPF are as hormonally active as BPA, and they have endocrine-disrupting effects.

Citation: Rochester JR, Bolden AL. 2015. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes.

No MeSH data available.


Related in: MedlinePlus

Risk of bias (RoB) ratings for BPS and BPF in vivo studies. Abbreviations: ++, definitely low risk of bias; +, probably low risk of bias; –, probably high risk of bias; NA, not applicable.
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f2: Risk of bias (RoB) ratings for BPS and BPF in vivo studies. Abbreviations: ++, definitely low risk of bias; +, probably low risk of bias; –, probably high risk of bias; NA, not applicable.

Mentions: Study quality for in vivo studies was assessed using a protocol developed by OHAT. Briefly, risk of bias (RoB) in experimental methodology was assessed by answering 14 questions. The RoB questions covered biases in subject selection, protocol performance, attrition/exclusion of subjects, detection of outcomes, selective reporting of outcomes, and statistical methodology. Questions were rated as “definitely low RoB,” “probably low RoB,” “probably high RoB,” or “definitely high RoB” depending on standardized responses. The individual RoB questions are provided in Figure 2. Next, “key” study quality questions, identified a priori, were used to determine the initial quality of each study, then ratings of the remaining questions were used to determine the overall study quality: “low,” “moderate,” or “high.” If any study received a “low” rating, it was removed from analysis. This protocol has been described in detail elsewhere (National Toxicology Program 2013; Rooney et al. 2014).


Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes.

Rochester JR, Bolden AL - Environ. Health Perspect. (2015)

Risk of bias (RoB) ratings for BPS and BPF in vivo studies. Abbreviations: ++, definitely low risk of bias; +, probably low risk of bias; –, probably high risk of bias; NA, not applicable.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492270&req=5

f2: Risk of bias (RoB) ratings for BPS and BPF in vivo studies. Abbreviations: ++, definitely low risk of bias; +, probably low risk of bias; –, probably high risk of bias; NA, not applicable.
Mentions: Study quality for in vivo studies was assessed using a protocol developed by OHAT. Briefly, risk of bias (RoB) in experimental methodology was assessed by answering 14 questions. The RoB questions covered biases in subject selection, protocol performance, attrition/exclusion of subjects, detection of outcomes, selective reporting of outcomes, and statistical methodology. Questions were rated as “definitely low RoB,” “probably low RoB,” “probably high RoB,” or “definitely high RoB” depending on standardized responses. The individual RoB questions are provided in Figure 2. Next, “key” study quality questions, identified a priori, were used to determine the initial quality of each study, then ratings of the remaining questions were used to determine the overall study quality: “low,” “moderate,” or “high.” If any study received a “low” rating, it was removed from analysis. This protocol has been described in detail elsewhere (National Toxicology Program 2013; Rooney et al. 2014).

Bottom Line: Further, we compared the hormonal potency of BPS and BPF to that of BPA.The majority of these studies examined the hormonal activities of BPS and BPF and found their potency to be in the same order of magnitude and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro and in vivo.Based on the current literature, BPS and BPF are as hormonally active as BPA, and they have endocrine-disrupting effects.

View Article: PubMed Central - PubMed

Affiliation: The Endocrine Disruption Exchange (TEDX), Paonia, Colorado, USA.

ABSTRACT

Background: Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled "BPA-free." Some of the chemical replacements, however, are also bisphenols and may have similar physiological effects in organisms. Bisphenol S (BPS) and bisphenol F (BPF) are two such BPA substitutes.

Objectives: This review was carried out to evaluate the physiological effects and endocrine activities of the BPA substitutes BPS and BPF. Further, we compared the hormonal potency of BPS and BPF to that of BPA.

Methods: We conducted a systematic review based on the Office of Health Assessment and Translation (OHAT) protocol.

Results: We identified the body of literature to date, consisting of 32 studies (25 in vitro only, and 7 in vivo). The majority of these studies examined the hormonal activities of BPS and BPF and found their potency to be in the same order of magnitude and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro and in vivo. BPS also has potencies similar to that of estradiol in membrane-mediated pathways, which are important for cellular actions such as proliferation, differentiation, and death. BPS and BPF also showed other effects in vitro and in vivo, such as altered organ weights, reproductive end points, and enzyme expression.

Conclusions: Based on the current literature, BPS and BPF are as hormonally active as BPA, and they have endocrine-disrupting effects.

Citation: Rochester JR, Bolden AL. 2015. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes.

No MeSH data available.


Related in: MedlinePlus