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Free Flap Donor Site Reconstruction: A Prospective Case Series Using an Optimized Polyurethane Biodegradable Temporizing Matrix.

Wagstaff MJ, Schmitt BJ, Caplash Y, Greenwood JE - Eplasty (2015)

Bottom Line: Long-term scar outcomes improved compared with the pilot group.This study has reiterated that the biodegradable temporizing matrix can be implanted into humans, followed by neovascularization and integration.No infection was observed, and split-skin overgrafting was successful and uncomplicated.

View Article: PubMed Central - PubMed

Affiliation: Adult Burn Centre, Royal Adelaide Hospital, Adelaide, South Australia, Australia ; Department of Plastic and Reconstructive Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

ABSTRACT

Introduction: We recently published a 10-patient case series where free flap donor site reconstruction was performed as a 2-stage procedure using an integrating biodegradable polyurethane matrix (to form a neodermis), followed by definitive closure with an autologous split-skin graft. Two issues were revealed by this pilot study that led to further modification of the biodegradable temporizing matrix. This involved alterations to the seal thickness and bonding to the foam matrix and the introduction of fenestrations to the seal.

Objective: This article documents a second cohort of patients requiring free flap (fibular and radial forearm) donor site reconstruction with this optimized material.

Methods: The biodegradable temporizing matrix was implanted when the free flap was detached from its donor site. Subsequent integration was monitored closely. Five weeks was the usual time of integration before delamination (seal removal), dermabrasion, and definitive closure with autograft.

Results: Integration was complete and uncomplicated in every case, delamination occurred in 1 piece in 1 action, and subsequent graft take was 100% for every patient. Long-term scar outcomes improved compared with the pilot group. Degradation is complete by 12 months, other than occasional microscopic remnants undergoing phagocytosis.

Conclusion: This study has reiterated that the biodegradable temporizing matrix can be implanted into humans, followed by neovascularization and integration. No infection was observed, and split-skin overgrafting was successful and uncomplicated.

No MeSH data available.


Related in: MedlinePlus

Patient 1 temporal series: (a) day 0 wound; (b) day 0 BTM implanted; (c) day 34 BTM delaminated and dermabraded; and (d) day 367 final graft BTM/scar. BTM indicates biodegradable temporizing matrix.
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Figure 1: Patient 1 temporal series: (a) day 0 wound; (b) day 0 BTM implanted; (c) day 34 BTM delaminated and dermabraded; and (d) day 367 final graft BTM/scar. BTM indicates biodegradable temporizing matrix.

Mentions: The BTM took completely in all patients surviving until grafting and was integrating normally in patient 5, who died of an unrelated surgical complication at day 12 postimplantation. This can be seen in the third picture of each patient series (Figs 1–10).


Free Flap Donor Site Reconstruction: A Prospective Case Series Using an Optimized Polyurethane Biodegradable Temporizing Matrix.

Wagstaff MJ, Schmitt BJ, Caplash Y, Greenwood JE - Eplasty (2015)

Patient 1 temporal series: (a) day 0 wound; (b) day 0 BTM implanted; (c) day 34 BTM delaminated and dermabraded; and (d) day 367 final graft BTM/scar. BTM indicates biodegradable temporizing matrix.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492216&req=5

Figure 1: Patient 1 temporal series: (a) day 0 wound; (b) day 0 BTM implanted; (c) day 34 BTM delaminated and dermabraded; and (d) day 367 final graft BTM/scar. BTM indicates biodegradable temporizing matrix.
Mentions: The BTM took completely in all patients surviving until grafting and was integrating normally in patient 5, who died of an unrelated surgical complication at day 12 postimplantation. This can be seen in the third picture of each patient series (Figs 1–10).

Bottom Line: Long-term scar outcomes improved compared with the pilot group.This study has reiterated that the biodegradable temporizing matrix can be implanted into humans, followed by neovascularization and integration.No infection was observed, and split-skin overgrafting was successful and uncomplicated.

View Article: PubMed Central - PubMed

Affiliation: Adult Burn Centre, Royal Adelaide Hospital, Adelaide, South Australia, Australia ; Department of Plastic and Reconstructive Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

ABSTRACT

Introduction: We recently published a 10-patient case series where free flap donor site reconstruction was performed as a 2-stage procedure using an integrating biodegradable polyurethane matrix (to form a neodermis), followed by definitive closure with an autologous split-skin graft. Two issues were revealed by this pilot study that led to further modification of the biodegradable temporizing matrix. This involved alterations to the seal thickness and bonding to the foam matrix and the introduction of fenestrations to the seal.

Objective: This article documents a second cohort of patients requiring free flap (fibular and radial forearm) donor site reconstruction with this optimized material.

Methods: The biodegradable temporizing matrix was implanted when the free flap was detached from its donor site. Subsequent integration was monitored closely. Five weeks was the usual time of integration before delamination (seal removal), dermabrasion, and definitive closure with autograft.

Results: Integration was complete and uncomplicated in every case, delamination occurred in 1 piece in 1 action, and subsequent graft take was 100% for every patient. Long-term scar outcomes improved compared with the pilot group. Degradation is complete by 12 months, other than occasional microscopic remnants undergoing phagocytosis.

Conclusion: This study has reiterated that the biodegradable temporizing matrix can be implanted into humans, followed by neovascularization and integration. No infection was observed, and split-skin overgrafting was successful and uncomplicated.

No MeSH data available.


Related in: MedlinePlus