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Cell-penetrating peptides and their analogues as novel nanocarriers for drug delivery.

Jafari S, Maleki Dizaj S, Adibkia K - Bioimpacts (2015)

Bottom Line: In addition to the cell-penetrating peptide dendrimer (DCPP), other analogues of CPPs have been synthesized.In addition, nanoconjugates and bioconjugates of these peptide sequences are discussed.DCCP, branched CPPs, compared to linear peptides have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.

View Article: PubMed Central - HTML - PubMed

Affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran ; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

ABSTRACT

Introduction: The impermeability of biological membranes is a major obstacle in drug delivery; however, some peptides have transition capabilities of biomembranes. In recent decades, cell-penetrating peptides (CPPs) have been introduced as novel biocarriers that are able to translocate into the cells. CPPs are biologically potent tools for non-invasive cellular internalization of cargo molecules. Nevertheless, the non-specificity of these peptides presents a restriction for targeting drug delivery; therefore, a peptidic nanocarrier sensitive to matrix metalloproteinase (MMP) has been prepared, called activatable cell-penetrating peptide (ACPP). In addition to the cell-penetrating peptide dendrimer (DCPP), other analogues of CPPs have been synthesized.

Methods: In this study, the most recent literature in the field of biomedical application of CPPs and their analogues, ACPP and DCCP, were reviewed.

Results: This review focuses on CPP and its analogues, ACPP and DCPP, as novel nanocarriers for drug delivery. In addition, nanoconjugates and bioconjugates of these peptide sequences are discussed.

Conclusion: DCCP, branched CPPs, compared to linear peptides have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.

No MeSH data available.


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Mentions: Therapeutic peptides have a typically linear structure, but branched peptides are also found in nature. Highly branched structure, the so-called dendrimer, is derived from the Greek word, dendron, meaning tree. In the last few years, CCP dendrimers (DCCPs) as novel peptide carriers have attracted a great deal of attention. Dendrimers, in comparison to many linear peptides, have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.91,92Fig. 3 demonstrates the dendritic structure of DCCP. In a study, polyester-based dendritic guanidine with a focal point alkyne conjugated to Fe3O4 nanoparticles has been used for enhancement of the cellular uptake of these particles. Investigations demonstrated that the functionalization of Fe3O4 nanoparticles with branched guanidine led to the increase of cell uptake and the improvement of the ability to detect the cells by MRI.93


Cell-penetrating peptides and their analogues as novel nanocarriers for drug delivery.

Jafari S, Maleki Dizaj S, Adibkia K - Bioimpacts (2015)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492185&req=5

Mentions: Therapeutic peptides have a typically linear structure, but branched peptides are also found in nature. Highly branched structure, the so-called dendrimer, is derived from the Greek word, dendron, meaning tree. In the last few years, CCP dendrimers (DCCPs) as novel peptide carriers have attracted a great deal of attention. Dendrimers, in comparison to many linear peptides, have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.91,92Fig. 3 demonstrates the dendritic structure of DCCP. In a study, polyester-based dendritic guanidine with a focal point alkyne conjugated to Fe3O4 nanoparticles has been used for enhancement of the cellular uptake of these particles. Investigations demonstrated that the functionalization of Fe3O4 nanoparticles with branched guanidine led to the increase of cell uptake and the improvement of the ability to detect the cells by MRI.93

Bottom Line: In addition to the cell-penetrating peptide dendrimer (DCPP), other analogues of CPPs have been synthesized.In addition, nanoconjugates and bioconjugates of these peptide sequences are discussed.DCCP, branched CPPs, compared to linear peptides have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.

View Article: PubMed Central - HTML - PubMed

Affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran ; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

ABSTRACT

Introduction: The impermeability of biological membranes is a major obstacle in drug delivery; however, some peptides have transition capabilities of biomembranes. In recent decades, cell-penetrating peptides (CPPs) have been introduced as novel biocarriers that are able to translocate into the cells. CPPs are biologically potent tools for non-invasive cellular internalization of cargo molecules. Nevertheless, the non-specificity of these peptides presents a restriction for targeting drug delivery; therefore, a peptidic nanocarrier sensitive to matrix metalloproteinase (MMP) has been prepared, called activatable cell-penetrating peptide (ACPP). In addition to the cell-penetrating peptide dendrimer (DCPP), other analogues of CPPs have been synthesized.

Methods: In this study, the most recent literature in the field of biomedical application of CPPs and their analogues, ACPP and DCCP, were reviewed.

Results: This review focuses on CPP and its analogues, ACPP and DCPP, as novel nanocarriers for drug delivery. In addition, nanoconjugates and bioconjugates of these peptide sequences are discussed.

Conclusion: DCCP, branched CPPs, compared to linear peptides have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.

No MeSH data available.