Limits...
Cell-penetrating peptides and their analogues as novel nanocarriers for drug delivery.

Jafari S, Maleki Dizaj S, Adibkia K - Bioimpacts (2015)

Bottom Line: In addition to the cell-penetrating peptide dendrimer (DCPP), other analogues of CPPs have been synthesized.In addition, nanoconjugates and bioconjugates of these peptide sequences are discussed.DCCP, branched CPPs, compared to linear peptides have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.

View Article: PubMed Central - HTML - PubMed

Affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran ; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

ABSTRACT

Introduction: The impermeability of biological membranes is a major obstacle in drug delivery; however, some peptides have transition capabilities of biomembranes. In recent decades, cell-penetrating peptides (CPPs) have been introduced as novel biocarriers that are able to translocate into the cells. CPPs are biologically potent tools for non-invasive cellular internalization of cargo molecules. Nevertheless, the non-specificity of these peptides presents a restriction for targeting drug delivery; therefore, a peptidic nanocarrier sensitive to matrix metalloproteinase (MMP) has been prepared, called activatable cell-penetrating peptide (ACPP). In addition to the cell-penetrating peptide dendrimer (DCPP), other analogues of CPPs have been synthesized.

Methods: In this study, the most recent literature in the field of biomedical application of CPPs and their analogues, ACPP and DCCP, were reviewed.

Results: This review focuses on CPP and its analogues, ACPP and DCPP, as novel nanocarriers for drug delivery. In addition, nanoconjugates and bioconjugates of these peptide sequences are discussed.

Conclusion: DCCP, branched CPPs, compared to linear peptides have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.

No MeSH data available.


© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4492185&req=5

Mentions: CPPs, despite their many advantages, have limited in vivo application due to their non-specificity. Lately, a novel strategy of CPPs, called activatable cell- penetrating peptides (ACCPs), is used in targeted cargo delivery. ACPPs, new CPPs with high permeability, are composed of a polycationic cell-penetrating peptide attached to a polyanionic peptide through a cleavable linker and sensitive to metalloproteinase (MMP).6,85 As a result of the high level of expression of MMP in tumour cells, ACPPs can be used for site-specific targeting and delivery of anticancer drugs. Indeed, MMPs are disease biomarkers which can be used for improvement of diagnosis or application in image-guided surgery with radiolabeled MMP binding ligands, such as antibodies or small molecules.87,88 Detection of MMP activity in tumours by radiolabeled ACPPs has been identified as a strong enhancement of tumour retention in vivo. Fig. 2 schematically demonstrates ACCP and its internalization into the cell.


Cell-penetrating peptides and their analogues as novel nanocarriers for drug delivery.

Jafari S, Maleki Dizaj S, Adibkia K - Bioimpacts (2015)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492185&req=5

Mentions: CPPs, despite their many advantages, have limited in vivo application due to their non-specificity. Lately, a novel strategy of CPPs, called activatable cell- penetrating peptides (ACCPs), is used in targeted cargo delivery. ACPPs, new CPPs with high permeability, are composed of a polycationic cell-penetrating peptide attached to a polyanionic peptide through a cleavable linker and sensitive to metalloproteinase (MMP).6,85 As a result of the high level of expression of MMP in tumour cells, ACPPs can be used for site-specific targeting and delivery of anticancer drugs. Indeed, MMPs are disease biomarkers which can be used for improvement of diagnosis or application in image-guided surgery with radiolabeled MMP binding ligands, such as antibodies or small molecules.87,88 Detection of MMP activity in tumours by radiolabeled ACPPs has been identified as a strong enhancement of tumour retention in vivo. Fig. 2 schematically demonstrates ACCP and its internalization into the cell.

Bottom Line: In addition to the cell-penetrating peptide dendrimer (DCPP), other analogues of CPPs have been synthesized.In addition, nanoconjugates and bioconjugates of these peptide sequences are discussed.DCCP, branched CPPs, compared to linear peptides have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.

View Article: PubMed Central - HTML - PubMed

Affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran ; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

ABSTRACT

Introduction: The impermeability of biological membranes is a major obstacle in drug delivery; however, some peptides have transition capabilities of biomembranes. In recent decades, cell-penetrating peptides (CPPs) have been introduced as novel biocarriers that are able to translocate into the cells. CPPs are biologically potent tools for non-invasive cellular internalization of cargo molecules. Nevertheless, the non-specificity of these peptides presents a restriction for targeting drug delivery; therefore, a peptidic nanocarrier sensitive to matrix metalloproteinase (MMP) has been prepared, called activatable cell-penetrating peptide (ACPP). In addition to the cell-penetrating peptide dendrimer (DCPP), other analogues of CPPs have been synthesized.

Methods: In this study, the most recent literature in the field of biomedical application of CPPs and their analogues, ACPP and DCCP, were reviewed.

Results: This review focuses on CPP and its analogues, ACPP and DCPP, as novel nanocarriers for drug delivery. In addition, nanoconjugates and bioconjugates of these peptide sequences are discussed.

Conclusion: DCCP, branched CPPs, compared to linear peptides have advantages such as resistance to rapid biodegradation, high loading capacities and large-scale production capability.

No MeSH data available.