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Effects of Ramadan Fasting on Serum Amyloid A and Protein Carbonyl Group Levels in Patients With Cardiovascular Diseases.

Asadi H, Abolfathi AA, Badalzadeh R, Majidinia M, Yaghoubi A, Asadi M, Yousefi B - J Cardiovasc Thorac Res (2015)

Bottom Line: In addition, Ramadan fasting significantly reduced the levels of protein carbonyl group in patients as compared with those of baseline values (33.08±15.31 vs. 43.65±16.88 nmol/ml, P = 0.039).Ramadan fasting has impressive effects on modulating CVDs by decreasing inflammation and oxidative stress markers.However, to get a clear conclusion with more results, further investigation is warranted.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Biological Science, Ahar Branch, Islamic Azad University, Ahar, Iran.

ABSTRACT

Introduction: Serum amyloid-A (SAA) and protein carbonyl group are rigorously related with cardiovascular diseases (CVDs) as a sensitive marker of an acute inflammatory state and as an important index of oxidative stress, respectively. Moreover, diet is one of the main factors that can modify cardiovascular risks. Therefore, this study aimed to investigate the effects of Ramadan fasting on SAA and protein carbonyl group levels in patients with CVDs.

Methods: Twenty-one patients (21 male; mean age 52±9 years old) with CVDs (coronary artery disease, cerebrovascular, or peripheral arterial diseases) were participated in this study. Biochemical parameters were measured in patients 2 days before and 2 days after Ramadan fasting. SAA levels were assessed using enzyme-linked immunosorbent assay and Cayman's protein carbonyl colorimetric assay was provided for measuring protein carbonyl groups.

Results: According to the findings of the study, post-Ramadan levels of inflammatory biomarker, SAA was decreased significantly in patients with CVDs in comparison with the baseline before-fasting values (16.84±8.20 vs. 24.40±6.72 μg/ml, P = 0.021). In addition, Ramadan fasting significantly reduced the levels of protein carbonyl group in patients as compared with those of baseline values (33.08±15.31 vs. 43.65±16.88 nmol/ml, P = 0.039).

Conclusion: Ramadan fasting has impressive effects on modulating CVDs by decreasing inflammation and oxidative stress markers. However, to get a clear conclusion with more results, further investigation is warranted.

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Mentions: The presence of carbonyl groups in proteins was determined in patients with CVDs after Ramadan fasting as an indicator of protein oxidation by oxidative stress. Post-Ramadan fasting levels of this biomarker was lower than pre-Ramadan fasting levels, and this difference was statistically significant (33.08±15.31 vs. 43.65±16.88 nmol/ml, P = 0.039, Figure 2).


Effects of Ramadan Fasting on Serum Amyloid A and Protein Carbonyl Group Levels in Patients With Cardiovascular Diseases.

Asadi H, Abolfathi AA, Badalzadeh R, Majidinia M, Yaghoubi A, Asadi M, Yousefi B - J Cardiovasc Thorac Res (2015)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492178&req=5

Mentions: The presence of carbonyl groups in proteins was determined in patients with CVDs after Ramadan fasting as an indicator of protein oxidation by oxidative stress. Post-Ramadan fasting levels of this biomarker was lower than pre-Ramadan fasting levels, and this difference was statistically significant (33.08±15.31 vs. 43.65±16.88 nmol/ml, P = 0.039, Figure 2).

Bottom Line: In addition, Ramadan fasting significantly reduced the levels of protein carbonyl group in patients as compared with those of baseline values (33.08±15.31 vs. 43.65±16.88 nmol/ml, P = 0.039).Ramadan fasting has impressive effects on modulating CVDs by decreasing inflammation and oxidative stress markers.However, to get a clear conclusion with more results, further investigation is warranted.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Biological Science, Ahar Branch, Islamic Azad University, Ahar, Iran.

ABSTRACT

Introduction: Serum amyloid-A (SAA) and protein carbonyl group are rigorously related with cardiovascular diseases (CVDs) as a sensitive marker of an acute inflammatory state and as an important index of oxidative stress, respectively. Moreover, diet is one of the main factors that can modify cardiovascular risks. Therefore, this study aimed to investigate the effects of Ramadan fasting on SAA and protein carbonyl group levels in patients with CVDs.

Methods: Twenty-one patients (21 male; mean age 52±9 years old) with CVDs (coronary artery disease, cerebrovascular, or peripheral arterial diseases) were participated in this study. Biochemical parameters were measured in patients 2 days before and 2 days after Ramadan fasting. SAA levels were assessed using enzyme-linked immunosorbent assay and Cayman's protein carbonyl colorimetric assay was provided for measuring protein carbonyl groups.

Results: According to the findings of the study, post-Ramadan levels of inflammatory biomarker, SAA was decreased significantly in patients with CVDs in comparison with the baseline before-fasting values (16.84±8.20 vs. 24.40±6.72 μg/ml, P = 0.021). In addition, Ramadan fasting significantly reduced the levels of protein carbonyl group in patients as compared with those of baseline values (33.08±15.31 vs. 43.65±16.88 nmol/ml, P = 0.039).

Conclusion: Ramadan fasting has impressive effects on modulating CVDs by decreasing inflammation and oxidative stress markers. However, to get a clear conclusion with more results, further investigation is warranted.

No MeSH data available.


Related in: MedlinePlus